Zobrazeno 1 - 10 of 307 pro vyhledávání: '"Lynn M Matrisian"'
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Akademický článek
Keratin 17 modulates the immune topography of pancreatic cancer
Autor: Lyanne Delgado-Coka, Michael Horowitz, Mariana Torrente-Goncalves, Lucia Roa-Peña, Cindy V. Leiton, Mahmudul Hasan, Sruthi Babu, Danielle Fassler, Jaymie Oentoro, Ji-Dong K Bai, Emanuel F. Petricoin, Lynn M. Matrisian, Edik Matthew Blais, Natalia Marchenko, Felicia D. Allard, Wei Jiang, Brent Larson, Andrew Hendifar, Chao Chen, Shahira Abousamra, Dimitris Samaras, Tahsin Kurc, Joel Saltz, Luisa F. Escobar-Hoyos, Kenneth R. Shroyer
Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background The immune microenvironment impacts tumor growth, invasion, metastasis, and patient survival and may provide opportunities for therapeutic intervention in pancreatic ductal adenocarcinoma (PDAC). Although never studied as a potent
Externí odkaz: https://doaj.org/article/d0bfc3b841b643c9bb6db994b3bb87d5
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3
Akademický článek
An osteoblast-derived proteinase controls tumor cell survival via TGF-beta activation in the bone microenvironment.
Autor: Sophie Thiolloy, James R Edwards, Barbara Fingleton, Daniel B Rifkin, Lynn M Matrisian, Conor C Lynch
Publikováno v: PLoS ONE, Vol 7, Iss 1, p e29862 (2012)
Breast to bone metastases frequently induce a "vicious cycle" in which osteoclast mediated bone resorption and proteolysis results in the release of bone matrix sequestered factors that drive tumor growth. While osteoclasts express numerous proteinas
Externí odkaz: https://doaj.org/article/92a678089e744f57baf73db6171a78ed
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4
Akademický článek
Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model.
Autor: D Lee Gorden, Pavlina T Ivanova, David S Myers, J Oliver McIntyre, Michael N VanSaun, J Kelly Wright, Lynn M Matrisian, H Alex Brown
Publikováno v: PLoS ONE, Vol 6, Iss 8, p e22775 (2011)
The spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis, nonalcoholic steatohepatitis (NASH), and progression to cirrhosis. While differences in liver lipids between disease states have been reported, precise composition of phosph
Externí odkaz: https://doaj.org/article/abedb460b8734f788c5fef1d916d0f65
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5
Akademický článek
Anti-transforming growth factor ß antibody treatment rescues bone loss and prevents breast cancer metastasis to bone.
Autor: Swati Biswas, Jeffry S Nyman, JoAnn Alvarez, Anwesa Chakrabarti, Austin Ayres, Julie Sterling, James Edwards, Tapasi Rana, Rachelle Johnson, Daniel S Perrien, Scott Lonning, Yu Shyr, Lynn M Matrisian, Gregory R Mundy
Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27090 (2011)
Breast cancer often metastasizes to bone causing osteolytic bone resorption which releases active TGFβ. Because TGFβ favors progression of breast cancer metastasis to bone, we hypothesized that treatment using anti-TGFβ antibody may reduce tumor b
Externí odkaz: https://doaj.org/article/a451666303a044c88e3a0e3d8c5f2365
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9
Data from Loss of TGF-β Responsiveness in Prostate Stromal Cells Alters Chemokine Levels and Facilitates the Development of Mixed Osteoblastic/Osteolytic Bone Lesions
Autor: Neil A. Bhowmick, Lynn M. Matrisian, Simon W. Hayward, Yu Shyr, Robert L. Vessella, Kang-Hsien Fan, Julie A. Sterling, Xiaohong Li
Loss of TGF-β type II receptor (TβRII, encoded by Tgfbr2) expression in the prostate stroma contributes to prostate cancer initiation, progression, and invasion. We evaluated whether TβRII loss also affected prostate cancer bone metastatic growth.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069b0ab3b9c71f6a5fb78b56441778ba
https://doi.org/10.1158/1541-7786.c.6541434.v1
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