Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Lynn Lamoreux"'
Autor:
Lynn Lamoreux, Dorothy Bennett
Publikováno v:
The Journal of Population and Sustainability, Vol 8, Iss 1, Pp 95-111 (2024)
A biological system can be defined as a collection of interacting elements, organised together with a common function(s). This framework can provide valuable insights into the problematic interactions between humanity and the rest of life on earth. L
Externí odkaz:
https://doaj.org/article/cdde332c78f0468ab2ceb45af77cc465
Autor:
Danièle Tenza, Steven T. Truschel, Dorothy C. Bennett, M. Lynn Lamoreux, Graça Raposo, Evelyn Chou, Alexander C. Theos, Marta Starcevic, Santiago M. Di Pietro, Subba Rao Gangi Setty, Elena V. Sviderskaya, Michael S. Marks, Esteban C. Dell'Angelica
Publikováno v:
Molecular Biology of the Cell
Hermansky-Pudlak syndrome (HPS) is a genetic disorder characterized by defects in the formation and function of lysosome-related organelles such as melanosomes. HPS in humans or mice is caused by mutations in any of 15 genes, five of which encode sub
Autor:
Kazumasa Wakamatsu, Francisco Solano, M. Lynn Lamoreux, Shosuke Ito, Gertrude-E. Costin, Adina L. Milac, Yuji Yamaguchi, Vincent J. Hearing, Andrei J. Petrescu, Francois Rouzaud, Wilfred D. Vieira, Julio C. Valencia
Publikováno v:
Biochemical Journal. 391:249-259
Dopachrome tautomerase (Dct) is a type I membrane protein and an important regulatory enzyme that plays a pivotal role in the biosynthesis of melanin and in the rapid metabolism of its toxic intermediates. Dct-mutant melanocytes carrying the slaty or
Autor:
Elena V. Sviderskaya, Richard A. Spritz, Songtao Ben, Edward K. Novak, Kazumasa Wakamatsu, William A. Gahl, Wei Li, Sreenivasulu Chintala, Young-Mee Park, Richard T. Swank, Dorothy C. Bennett, Shosuke Ito, Jian Tan, M. Lynn Lamoreux, Marjan Huizing
Publikováno v:
Proceedings of the National Academy of Sciences. 102:10964-10969
In mammals, >100 genes regulate pigmentation by means of a wide variety of developmental, cellular, and enzymatic mechanisms. Nevertheless, genes that directly regulate pheomelanin production have not been described. Here, we demonstrate that the sub
Publikováno v:
Pigment Cell Research. 18:64-73
For the study of development of pigmentation, compared with mammalian models, fish offer the advantage of multiple chromatophore types and ready access to the developing embryo for observation and experimental manipulation. Compared with zebrafish em
Publikováno v:
Journal of Cell Science. 117:6401-6412
Small GTPases of the Rab family are key regulators of membrane trafficking. Each Rab shows a characteristic subcellular distribution, and may serve as an important determinant of organelle identity. The molecular mechanisms responsible for targeting
Autor:
Wilfred D. Vieira, M. Lynn Lamoreux, Gertrude-E. Costin, Francois Rouzaud, Julio C. Valencia, Vincent J. Hearing
Publikováno v:
Analytical Biochemistry. 335:171-174
Autor:
Keisuke Oboki, Tomohiko Wakayama, Yukihiko Kitamura, Yu-ichiro Koma, Tomoko Jippo, Eiichi Morii, M. Lynn Lamoreux, Akihiko Ito, Shoichi Iseki
Publikováno v:
The American Journal of Pathology. 165:491-499
The mi (microphthalmia) locus of mice encodes a transcription factor, MITF. B6-tg/tg mice that do not express any MITF have white coats and small eyes. Moreover, the number of mast cells decreased to one-third that of normal control (+/+) mice in the
Autor:
Eiríkur Steingrímsson, Nancy A. Jenkins, Neal G. Copeland, Heinz Arnheiter, Jón Hallsteinn Hallsson, M. Lynn Lamoreux
Publikováno v:
Genetics. 163:267-276
Mutations at the mouse microphthalmia locus (Mitf) affect the development of different cell types, including melanocytes, retinal pigment epithelial cells of the eye, and osteoclasts. The MITF protein is a member of the MYC supergene family of basic-