Zobrazeno 1 - 10 of 46 pro vyhledávání: '"Lynn Kee"'
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Akademický článek
Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration
Autor: Hao Huang, Alexander Gont, Lynn Kee, Ruben Dries, Kathrin Pfeifer, Bandana Sharma, David N. Debruyne, Matthew Harlow, Satyaki Sengupta, Jikui Guan, Caleb M. Yeung, Wenchao Wang, Bengt Hallberg, Ruth H. Palmer, Meredith S. Irwin, Rani E. George
Publikováno v: Cell Reports, Vol 36, Iss 2, Pp 109363- (2021)
Summary: Although activating mutations of the anaplastic lymphoma kinase (ALK) membrane receptor occur in ∼10% of neuroblastoma (NB) tumors, the role of the wild-type (WT) receptor, which is aberrantly expressed in most non-mutated cases, is unclea
Externí odkaz: https://doaj.org/article/4d42e574c9364bf5b62295a7b9c9fc0b
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2
CRISPR in butterflies: An undergraduate lab experience to inactivate wing patterning genes during development
Autor: Aamani Thulluru, Luisa Saad, Yasmin Nagah Abdou, Arnaud Martin, Hooi Lynn Kee
Publikováno v: Biochemistry and Molecular Biology Education. 50:605-619
CRISPR is a technique increasingly used in the laboratory for both fundamental and applied research. We designed and implemented a lab experience for undergraduates to carry out CRISPR technology in the lab, and knockout the wing patterning genes opt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7efe479dab6deb236e761ae6de2cbd22
https://doi.org/10.1002/bmb.21669
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Supplementary Figures S1-S10 from NRAS Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS–MAPK Pathway in Neuroblastoma
Autor: Meredith S. Irwin, Michael Ohh, Yoshihito Kano, Claire M. Robinson, Gabriella Christopher, Teresa Adderley, Lynn Kee, Yagnesh Ladumor, Ivette Valencia-Sama
Figure S1 - Sensitivity of NB cell lines to allosteric SHP2 inhibitors. Figure S2 - Sensitivity of NB cell lines to catalytic SHP2 inhibitors. Figure S3 - Sensitivity to SHP2 inhibitors in isogenic NB cells with exogenous PTPN11 mutations. Figure S4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187334f9bea6fde7f7a161526c078a2f
https://doi.org/10.1158/0008-5472.22423409.v1
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7
Data from NRAS Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS–MAPK Pathway in Neuroblastoma
Autor: Meredith S. Irwin, Michael Ohh, Yoshihito Kano, Claire M. Robinson, Gabriella Christopher, Teresa Adderley, Lynn Kee, Yagnesh Ladumor, Ivette Valencia-Sama
Survival for high-risk neuroblastoma remains poor and treatment for relapsed disease rarely leads to long-term cures. Large sequencing studies of neuroblastoma tumors from diagnosis have not identified common targetable driver mutations other than th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e4a403023b3fe6eacbd82ed89e6d606
https://doi.org/10.1158/0008-5472.c.6511493.v1
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8
Data from A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis
Autor: David R. Kaplan, Meredith S. Irwin, Cynthia E. Hawkins, Lynn Kee, Samar Mouaaz, Lincoln D. Stein, Christina K. Yung, Robin Hallett, Kelly E. Fathers, Bo Kyung A. Seong
Metastatic relapse is the major cause of death in pediatric neuroblastoma, where there remains a lack of therapies to target this stage of disease. To understand the molecular mechanisms mediating neuroblastoma metastasis, we developed a mouse model
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ee57c53564def9917ee6fb51d72a21f
https://doi.org/10.1158/0008-5472.c.6509016.v1
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