Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lynn Kamen"'
Autor:
M. Violet Lee, Ola M. Saad, Sylvia Wong, Jason LaMar, Lynn Kamen, Ben Ordonia, Rachel Melendez, Azadeh Hassanzadeh, Shan Chung, Surinder Kaur
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Major histocompatibility complex (MHC)-Associated Peptide Proteomics (MAPPs) is an ex vivo method used to assess the immunogenicity risk of biotherapeutics. MAPPs can identify potential T-cell epitopes within the biotherapeutic molecule. Using adalim
Externí odkaz:
https://doaj.org/article/0bd769f29dfe4b1888748f001e7e2a9e
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 6, Pp 1393-1399 (2022)
Abstract The treatment of diseases with biologic agents can result in the formation of antidrug antibodies (ADA). Although drivers for ADA formation are unknown, a role for antigen presentation is likely, and variation in human leukocyte antigen (HLA
Externí odkaz:
https://doaj.org/article/aa305244aea0411dafc2eccf80776734
Autor:
Ning Chai, Lee R. Swem, Summer Park, Gerald Nakamura, Nancy Chiang, Alberto Estevez, Rina Fong, Lynn Kamen, Elviza Kho, Mike Reichelt, Zhonghua Lin, Henry Chiu, Elizabeth Skippington, Zora Modrusan, Jeremy Stinson, Min Xu, Patrick Lupardus, Claudio Ciferri, Man-Wah Tan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Influenza B virus (IBV) co-circulates with influenza A virus to cause annual epidemics. Here, Chaiet al. isolate a human monoclonal antibody that binds to a conserved epitope in the viral HA protein, neutralizes IBV strains in vitro, and protects mic
Externí odkaz:
https://doaj.org/article/d697ead9ca194b4d8f53f1f10eadf047
Autor:
Ning Chai, Lee R. Swem, Summer Park, Gerald Nakamura, Nancy Chiang, Alberto Estevez, Rina Fong, Lynn Kamen, Elviza Kho, Mike Reichelt, Zhonghua Lin, Henry Chiu, Elizabeth Skippington, Zora Modrusan, Jeremy Stinson, Min Xu, Patrick Lupardus, Claudio Ciferri, Man-Wah Tan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-2 (2017)
Nature Communications 8: Article number: 14234 (2017); Published: 19 January 2017; Updated: 25 May 2017 This Article contains errors in Fig. 5c. The blue squares should be labelled ‘Water+46B8’ and the green triangles should be labelled ‘Tamifl
Externí odkaz:
https://doaj.org/article/fd4f9823a247424798f021121a6f98cd
Autor:
Rachel Melendez, Benjamin Ordonia, Joyce Guerrero, Azadeh Hassanzadeh, Peter Tran, Justin Low, Manda Wong, Jochen Brumm, Shan Chung, Lynn Kamen
Publikováno v:
Bioanalysis. 14:703-713
Aim: Immunogenicity risk assessment assays are powerful tools that assess the relative immunogenicity of potential biotherapeutics. We detail here the development of a novel assay that measures the degree of antibody internalization by antigen-presen
Publikováno v:
Clinical and Translational Science. 15:1393-1399
Autor:
Weize Huang, Junyi Li, Michael Z. Liao, Stephanie N. Liu, Jiajie Yu, Jing Jing, Naoki Kotani, Lynn Kamen, Sebastian Guelman, Dale R. Miles
Publikováno v:
Clinical pharmacology and therapeutics. 112(5)
Adoptive cell therapies (ACTs) have shown transformative efficacy in oncology with five US Food and Drug Administration (FDA) approvals for chimeric antigen receptor (CAR) T-cell therapies in hematological malignancies, and promising activity for T c
Publikováno v:
Therapeutic Antibodies ISBN: 9781071614495
Antibody-based therapeutics are powerful tools to treat disease. While their mechanism of action (MOA) always involves binding to a specific target via the antibody-binding fragment (Fab) region of the antibody, the induction of immune-mediated effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::755118eda5fd01d1cde00e96b48abd33
https://doi.org/10.1007/978-1-0716-1450-1_19
https://doi.org/10.1007/978-1-0716-1450-1_19
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2313
Antibody-based therapeutics are powerful tools to treat disease. While their mechanism of action (MOA) always involves binding to a specific target via the antibody-binding fragment (Fab) region of the antibody, the induction of immune-mediated effec
Publikováno v:
Journal of Immunological Methods. 468:49-54
Antibody-dependent cellular cytotoxicity (ADCC) is an important mechanism of action (MOA) of monoclonal antibody (mAb) therapeutics. Target cells opsonized with therapeutic antibody bind and activate FcγR-bearing immune effector cells, resulting in