Výsledky vyhledávání - "Lynn K. Boshkov"

Preoperative platelet dysfunction predicts blood product transfusion in children undergoing cardiac surgery

Autor: Lynn K. Boshkov, Sunil Saharan, Michael R. Lasarev, Paul Sochacki, Muhammad Zubair, Gurion Lantz, A. Roger Hohimer, David K. Bailly, Stephen M. Langley, Rachel E. Sunstrom

Publikováno v: Interactive CardioVascular and Thoracic Surgery. 20:24-30

OBJECTIVES: Excessive bleeding can be a problem during or after cardiac surgery. While cardiopulmonary bypass-associated platelet dysfunction is an important inducer of coagulopathy, preoperative platelet dysfunction can also contribute to this bleed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24bd1ee8e8c8aa62292e6d5e3519ec1
https://doi.org/10.1093/icvts/ivu315

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The Optimal Hematocrit

Autor: Louise Harder, Lynn K. Boshkov

Publikováno v: Critical Care Clinics. 26:335-354

Nearly 15 million units of packed red blood cells and whole blood are transfused annually in the United States alone. Until recently, the major risks from blood transfusion were thought to be transmission of viral infections, and overall, blood trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6567d1774cad96a415f5ad8312ef0bff
https://doi.org/10.1016/j.ccc.2010.01.002

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γA/γ’ fibrinogen inhibits thrombin-induced platelet aggregation

Autor: Sari A. Jouihan, Antony C. Bakke, Rehana S. Lovely, Chantelle M. Rein, Lynn K. Boshkov, David H. Farrell, Tara C. White, Owen J. T. McCarty

Publikováno v: Thrombosis and Haemostasis. 100:837-846

The minor gammaA/gamma' fibrinogen isoform contains a high affinity binding site for thrombin exosite II that is lacking in the major gammaA/gammaA fibrinogen isoform. We therefore investigated the biological consequences of the gamma' chain binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22c0f05c4ddc29669bb7bd83df87b7df
https://doi.org/10.1160/th08-03-0145

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Fibrinogen γ′ chain carboxy terminal peptide selectively inhibits the intrinsic coagulation pathway

Autor: Rehana S. Lovely, Stephen R. Hanson, Ulla M. Marzec, Lynn K. Boshkov, David H. Farrell

Publikováno v: British Journal of Haematology. 139:494-503

The minor gammaA/gamma' isoform of fibrinogen contains a high affinity binding site for thrombin exosite II that is lacking in the major fibrinogen isoform, gammaA/gammaA fibrinogen. The biological consequences of gamma' chain binding to thrombin wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4aa98cf75912308d7d0ea2d711bcae0
https://doi.org/10.1111/j.1365-2141.2007.06825.x

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Recognition and Management of Heparin-Induced Thrombocytopenia in Pediatric Cardiopulmonary Bypass Patients

Autor: Lynn K. Boshkov, Ross M. Ungerleider, Aileen Kirby, Irving Shen

Publikováno v: The Annals of Thoracic Surgery. 81:S2355-S2359

Repeated exposure to unfractionated heparin is the rule in many congenital heart disease patients. Heparin-induced thrombocytopenia occurs in 1% to 3% of adult cardiac surgeries, and carries high thrombotic morbidity (38% to 81%) and mortality (appro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9facf094b6dcb726cdeb2ed2fefd956e
https://doi.org/10.1016/j.athoracsur.2006.02.075

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Transfusion-related acute lung injury

Autor: Daniel R. Ambruso, Lynn K. Boshkov, Christopher C. Silliman

Publikováno v: Blood. 105:2266-2273

Transfusion-related acute lung injury (TRALI) is a life-threatening adverse effect of transfusion that is occurring at increasing incidence in the United States and that, in the past 2 reporting years, has been the leading cause of transfusion-relate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07156617acaf009e6edddf4ca74802f7
https://doi.org/10.1182/blood-2004-07-2929

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Sustained engraftment post bone marrow transplant despite anti-platelet antibodies in Glanzmann thrombasthenia

Autor: F. Leonard Johnson, Gregory Thomas, David Tilford, H. Stacy Nicholson, Lynn K. Boshkov, Kamar T. Godder, Veronica H. Flood, Mary P. Brown, Antony C. Bakke, Diane J. Nugent

Publikováno v: Pediatric Blood & Cancer. 45:971-975

Background Patients with Glanzmann thrombasthenia (GT) have normal platelet counts but abnormal platelet aggregation and carry the risk of life-threatening bleeding. We report three patients who received bone marrow transplantation (BMT) for type I G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d327cc8d2c66629199b9ed36968427
https://doi.org/10.1002/pbc.20365

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Hypotension and acute pulmonary insufficiency following transfusion of autologous red blood cells during surgery: a case report and review of the literature

Autor: Zahra Mehdizadehkashi, T. Masuno, Kelly M. England, Christopher C. Silliman, F. J. Kim, Marguerite R. Kelher, Ernest E. Moore, R. B. Covin, Daniel R. Ambruso, Lynn K. Boshkov

Publikováno v: Transfusion Medicine. 14:375-383

Transfusion of autologous blood is associated with fewer complications, although all untoward events of transfusion may not be negated with this strategy. We report a case of acute pulmonary insufficiency and hypotension following transfusion of auto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2c3bf50c80da7cbb947ffcc387bc63
https://doi.org/10.1111/j.0958-7578.2004.00529.x

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Congenital cardiac lesions involving systolic flow abnormalities are associated with platelet dysfunction in children

Autor: Julie Martchenke, Laurie B. Armsby, Paul Sochacki, Vanessa Rogers, A. Roger Hohimer, Lynn K. Boshkov, Muhammad Zubair, Gurion Lantz, David K. Bailly, Stephen M. Langley

Publikováno v: The Annals of thoracic surgery. 98(4)

Shear stress-induced platelet dysfunction (PD) is prevalent among adults with aortic stenosis. Our aim was to determine whether abnormal platelet function was associated with specific congenital cardiac lesions in children.The charts of 407 children

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad40e87eeea6456f03e97957eb17212
https://pubmed.ncbi.nlm.nih.gov/25130078

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