Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Lynn K. Barrett"'
Autor:
Cindy X. Zhang, Thomas M. Conrad, David Hermann, Melita A. Gordon, Eric Houpt, Pui‐Ying Iroh Tam, Khuzwayo C. Jere, Wilfred Nedi, Darwin J. Operario, Jacob Phulusa, Gerald V. Quinnan Jr, Leigh A. Sawyer, Lynn K. Barrett, Herbert Thole, Neema Toto, Wesley C. Van Voorhis, Samuel L. M. Arnold
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 3, Pp 410-423 (2024)
Abstract Oral drug absorption kinetics are usually established in populations with a properly functioning gastrointestinal tract. However, many diseases and therapeutics can alter gastrointestinal physiology and cause diarrhea. The extent of diarrhea
Externí odkaz:
https://doaj.org/article/eb41958c05d84d0fb5af26988b5b95cf
Autor:
Isabelle Q. Phan, Christopher A. Rice, Justin Craig, Rooksana E. Noorai, Jacquelyn R. McDonald, Sandhya Subramanian, Logan Tillery, Lynn K. Barrett, Vijay Shankar, James C. Morris, Wesley C. Van Voorhis, Dennis E. Kyle, Peter J. Myler
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Balamuthia mandrillaris, a pathogenic free-living amoeba, causes cutaneous skin lesions as well as granulomatous amoebic encephalitis, a ‘brain-eating’ disease. As with the other known pathogenic free-living amoebas (Naegleria fowleri an
Externí odkaz:
https://doaj.org/article/2f6501344d864a2aaccaf8376c641a80
Autor:
Anise N. Happi, Akeemat O. Ayinla, Olusola A. Ogunsanya, Ayotunde E. Sijuwola, Femi M. Saibu, Kazeem Akano, Uwem E. George, Adebayo E. Sopeju, Peter M. Rabinowitz, Kayode K. Ojo, Lynn K. Barrett, Wesley C. Van Voorhis, Christian T. Happi
Publikováno v:
Viruses, Vol 15, Iss 5, p 1187 (2023)
Since SARS-CoV-2 caused the COVID-19 pandemic, records have suggested the occurrence of reverse zoonosis of pets and farm animals in contact with SARS-CoV-2-positive humans in the Occident. However, there is little information on the spread of the vi
Externí odkaz:
https://doaj.org/article/d8fba1ab04614563a792615afc39ffc5
Autor:
Isabelle Q. Phan, Sandhya Subramanian, David Kim, Michael Murphy, Deleah Pettie, Lauren Carter, Ivan Anishchenko, Lynn K. Barrett, Justin Craig, Logan Tillery, Roger Shek, Whitney E. Harrington, David M. Koelle, Anna Wald, David Veesler, Neil King, Jim Boonyaratanakornkit, Nina Isoherranen, Alexander L. Greninger, Keith R. Jerome, Helen Chu, Bart Staker, Lance Stewart, Peter J. Myler, Wesley C. Van Voorhis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Rapid generation of diagnostics is paramount to understand epidemiology and to control the spread of emerging infectious diseases such as COVID-19. Computational methods to predict serodiagnostic epitopes that are specific for the pathogen c
Externí odkaz:
https://doaj.org/article/3d810cad4f2b46a1aaf7b89ba641e8bb
Autor:
Linhui Hao, Tien-Ying Hsiang, Ronit R. Dalmat, Renee Ireton, Jennifer F. Morton, Caleb Stokes, Jason Netland, Malika Hale, Chris Thouvenel, Anna Wald, Nicholas M. Franko, Kristen Huden, Helen Y. Chu, Alex Sigal, Alex L. Greninger, Sasha Tilles, Lynn K. Barrett, Wesley C. Van Voorhis, Jennifer Munt, Trevor Scobey, Ralph S. Baric, David J. Rawlings, Marion Pepper, Paul K. Drain, Michael Gale
Publikováno v:
Viruses, Vol 15, Iss 2, p 530 (2023)
New variants of SARS-CoV-2 continue to emerge and evade immunity. We isolated SARS-CoV-2 temporally across the pandemic starting with the first emergence of the virus in the western hemisphere and evaluated the immune escape among variants. A clinic-
Externí odkaz:
https://doaj.org/article/fdaa1f3636174da08d27e757b88a435b
Autor:
Neema Toto, Elaine Douglas, Markus Gmeiner, Lynn K. Barrett, Robert Lindblad, Lumbani Makhaza, Wilfred Nedi, Jacob Phulusa, Gerald V. Quinnan, Leigh A. Sawyer, Herbert Thole, Wesley C. Van Voorhis, Pui-Ying Iroh Tam
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-8 (2020)
Abstract Background An effective drug to treat cryptosporidial diarrhea in HIV-infected individuals is a global health priority. Promising drugs need to be evaluated in endemic areas which may be challenged by both lack of resources and experience to
Externí odkaz:
https://doaj.org/article/9a621b4daa5b42cf8cbb95c86626f894
Autor:
Aruna Shrestha, Kayode K. Ojo, Florian Koston, Bärbel Ruttkowski, Rama S.R. Vidadala, Carlie S. Dorr, Edelmar D. Navaluna, Grant R. Whitman, Kayleigh F. Barrett, Lynn K. Barrett, Matthew A. Hulverson, Ryan Choi, Samantha A. Michaels, Dustin J. Maly, Andrew Hemphill, Wesley C. Van Voorhis, Anja Joachim
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 10, Iss , Pp 9-19 (2019)
Cystoisosporosis is a leading diarrheal disease in suckling piglets. With the confirmation of resistance against the only available drug toltrazuril, there is a substantial need for novel therapeutics to combat the infection and its negative effects
Externí odkaz:
https://doaj.org/article/a1a719e47d4b426fa88a60a6c691ec34
Autor:
Roberto Sánchez-Sánchez, Ignacio Ferre, Michela Re, Patricia Vázquez, Luis Miguel Ferrer, Javier Blanco-Murcia, Javier Regidor-Cerrillo, Manuel Pizarro Díaz, Marta González-Huecas, Enrique Tabanera, Paula García-Lunar, Julio Benavides, Pablo Castaño, Andrew Hemphill, Matthew A. Hulverson, Grant R. Whitman, Kasey L. Rivas, Ryan Choi, Kayode K. Ojo, Lynn K. Barrett, Wesley C. Van Voorhis, Luis Miguel Ortega-Mora
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 1, Pp 112-124 (2018)
Neospora caninum is one of the main causes of abortion in cattle, and recent studies have highlighted its relevance as an abortifacient in small ruminants. Vaccines or drugs for the control of neosporosis are lacking. Bumped kinase inhibitors (BKIs),
Externí odkaz:
https://doaj.org/article/0d52162c3e134871b55bc67366d2ab9c
Autor:
Matthew A. Hulverson, Ryan Choi, Deborah A. Schaefer, Dana P. Betzer, Molly C. McCloskey, Grant R. Whitman, Wenlin Huang, Sangun Lee, Andy Pranata, Malcolm D. McLeod, Kennan C. Marsh, Dale J. Kempf, Bruce E. LeRoy, Mark T. Zafiratos, Aimee L. Bielinski, Robert C. Hackman, Kayode K. Ojo, Samuel L. M. Arnold, Lynn K. Barrett, Saul Tzipori, Michael W. Riggs, Erkang Fan, Wesley C. Van Voorhis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
Recent advances on the development of bumped kinase inhibitors for treatment of cryptosporidiosis have focused on the 5-aminopyrazole-4-carboxamide scaffold, due to analogs that have less hERG inhibition, superior efficacy, and strong in vitro safety
Autor:
Linhui Hao, Tien-Ying Hsiang, Ronit R. Dalmat, Renee Ireton, Jennifer Morton, Caleb Stokes, Jason Netland, Malika Hale, Chris Thouvenel, Anna Wald, Nicholas M Franko, Kristen Huden, Helen Chu, Alex Greninger, Sasha Tilles, Lynn K. Barrett, Wesley C. Van Voorhis, Jennifer Munt, Trevor Scobey, Ralph S. Baric, David Rawlings, Marion Pepper, Paul K. Drain, Michael Gale
Publikováno v:
medRxiv
To evaluate SARS-CoV-2 variants we isolated SARS-CoV-2 temporally during the pandemic starting with first appearance of virus in the Western hemisphere near Seattle, WA, USA, and isolated each known major variant class, revealing the dynamics of emer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd202273c917eafc30ea1c6824c6ee4
https://doi.org/10.1101/2022.08.12.22278720
https://doi.org/10.1101/2022.08.12.22278720