Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Lynn J. Guziec"'
Autor:
Asher Begleiter, Nadia El-Gabalawy, Laurie Lange, Marsha K. Leith, Lynn J. Guziec, Frank S. Guziec Jr
Publikováno v:
Drug Target Insights, Vol 2009, Iss 4, Pp 1-8 (2009)
NQO1 (NAD(P)H:quinoneoxidoreductase 1) is a reductive enzyme that is an important activator of bioreductive antitumor agents. NQO1 activity varies in individual tumors but is generally higher in tumor cells than in normal cells. NQO1 has been used as
Externí odkaz:
https://doaj.org/article/69737853a199495b94c1ec8fd990296c
Autor:
Asher Begleiter, Nadia El-Gabalawy, Laurie Lange, Marsha K. Leith, Lynn J. Guziec, Frank S. Guziec Jr
Publikováno v:
Drug Target Insights, Vol 4, Iss 1 (2009)
Abstract non disponibile
Externí odkaz:
https://doaj.org/article/0f861a75747f4c1f97dc85726c56b6f0
Autor:
Asher Begleiter, Nadia El-Gabalawy, Laurie Lange, Marsha K. Leith, Lynn J. Guziec, Frank S. Guziec
Publikováno v:
Drug Target Insights, Vol 4 (2009)
NQO1 (NAD(P)H:quinoneoxidoreductase 1) is a reductive enzyme that is an important activator of bioreductive antitumor agents. NQO1 activity varies in individual tumors but is generally higher in tumor cells than in normal cells. NQO1 has been used as
Externí odkaz:
https://doaj.org/article/86a00a54cb304a71b831e26a879caa3f
Autor:
Jennifer Lang, Brian B. Hasinoff, Kimberly K. Larson, Xing Wu, Jack C. Yalowich, Hong Liang, Lynn J. Guziec, Frank S. Jr. Guziec
Publikováno v:
Journal of Chemical Information and Modeling. 46:1827-1835
A series of 13 anthrapyrazole compounds that are analogues of piroxantrone and losoxantrone were synthesized, and their cell growth inhibitory effects, DNA binding, topoisomerase IIalpha mediated (EC 5.99.1.3) cleavage of DNA, and inhibition of DNA t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3931b756d218ab506d78f68ca6ab8afe
https://doi.org/10.1021/ci060056y
https://doi.org/10.1021/ci060056y
Autor:
Curtis J. Oleschuk, Frank S. Guziec, Lynn J. Guziec, Asher Begleiter, Cielo Monterrosa, Derek J. Fiterman, Jeanne Fourie
Publikováno v:
Cancer Chemotherapy and Pharmacology. 49:101-110
Purpose: Bioreductive antitumor agents are an important class of anticancer drugs that include the clinically used drug, mitomycin C, and new agents such as EO9 and tirapazamine that have recently been tested in clinical trials. These agents require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354bb8df834a693a781b9d3a0e738b93
https://doi.org/10.1007/s00280-001-0395-1
https://doi.org/10.1007/s00280-001-0395-1
Publikováno v:
Journal of Molecular Structure. 478:235-241
The X-ray structural investigation of tri(p-anisyl) selenonium trifluoroacetate, C23H21F3O5Se(H20)0.5 (I) has been carried out by means of three dimensional single-crystal diffractometry. The title compound (I) crystallizes in space group C2/c (No. 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c43ed87a3545711b50c8e6b4486c57d
https://doi.org/10.1016/s0022-2860(98)00761-3
https://doi.org/10.1016/s0022-2860(98)00761-3
Autor:
Lynn J. Guziec, Frank S. Guziec
Publikováno v:
Patai's Chemistry of Functional Groups
Insertion and extrusion reactions are common transformations in organoselenium and—tellurium chemistry. These processes are often synthetically useful, allowing for the preparation of molecules difficult or impossible to prepare using other methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fc2f03280f85639803e7d3e407ba9bb
https://doi.org/10.1002/9780470682531.pat0712
https://doi.org/10.1002/9780470682531.pat0712
Autor:
Dongchu Wei, Lynn J. Guziec, Ramesh Raghavachari, Ronald L. Felsted, Aravamudan S. Gopalan, Ratna Pankayatselvan, Constance J. Glover, Frank S. Guziec
Publikováno v:
Organic Preparations and Procedures International. 27:347-354
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::702fc4c56efb0b23850887f980ad32a5
https://doi.org/10.1080/00304949509458467
https://doi.org/10.1080/00304949509458467
Autor:
Frank S. Guziec, Lynn J. Guziec
Publikováno v:
Organic Reactions
Twofold extrusion reactions are chemical transformations in which two small inorganic molecules or atoms connecting carbon or nitrogen atoms are lost, generating the corresponding carbon-carbon or carbon-nitrogen double bonds. These reactions are par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96022ec766b67c849515d8e2b4a85518
https://doi.org/10.1002/0471264180.or078.03
https://doi.org/10.1002/0471264180.or078.03
Publikováno v:
Biochemical Pharmacology. 48:1447-1453
Methimazole (MMI), unlike propylthiouracil (PTU) is a poor inhibitor of type I iodothyronine deiodinase (ID-1). Inhibition of the enzyme by PTU was attributed initially to formation of a mixed disulfide between PTU and a cysteine residue at the activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d5bc9dcf2900c423d9c04e9061491a
https://doi.org/10.1016/0006-2952(94)90569-x
https://doi.org/10.1016/0006-2952(94)90569-x