Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Lynn H. Pottenger"'
Autor:
Nancy B. Beck, Richard A. Becker, Neeraja Erraguntla, William H. Farland, Roberta L. Grant, George Gray, Christopher Kirman, Judy S. LaKind, R. Jeffrey Lewis, Patricia Nance, Lynn H. Pottenger, Susan L. Santos, Stephanie Shirley, Ted Simon, Michael L. Dourson
Publikováno v:
Environment International, Vol 89, Iss , Pp 110-128 (2016)
Single point estimates of human health hazard/toxicity values such as a reference dose (RfD) are generally used in chemical hazard and risk assessment programs for assessing potential risks associated with site- or use-specific exposures. The resulti
Externí odkaz:
https://doaj.org/article/62792352456445b8b529ef53c6b98cf1
Publikováno v:
Journal of Toxicology, Vol 2011 (2011)
Ethylene oxide was tested on groups of rats for either 4-hour or 1-hour inhalation exposure, followed by 14 days of observation. Groups of five Sprague-Dawley rats/sex were exposed, and clinical signs and mortality were recorded. Clinical signs noted
Externí odkaz:
https://doaj.org/article/8a13e35c3e6249c39c2422af9724b571
Autor:
Judy S. LaKind, Carol J. Burns, Daniel Q. Naiman, Lynn H. Pottenger, Satori A. Marchitti, Julie E. Goodman
Publikováno v:
Critical reviews in toxicology. 51(6)
We utilized a practical, transparent approach for systematically reviewing a chemical-specific evidence base. This approach was used for a case study of ozone inhalation exposure and adverse metabolic effects (overweight/obesity, Type 1 diabetes [T1D
Autor:
John M. DeSesso, Lynn H. Pottenger, Robert A. Budinsky, Raymond G York, James S. Bus, Pragati S. Coder, Joelle M Lucarell, Christopher Bevan, Shiladitya Sen
Publikováno v:
Birth Defects Research
Background Trichloroethylene (TCE) was negative for developmental toxicity after inhalation and oral gavage exposure of pregnant rats but fetal cardiac defects were reported following drinking water exposure throughout gestation. Because of the defic
Autor:
Raymond G York, Joelle M Lucarell, John M. DeSesso, James S. Bus, Christopher Bevan, Lynn H. Pottenger, Robert A. Budinsky, Shiladitya Sen, Pragati S. Coder
Publikováno v:
Birth Defects Research. 111:1237-1239
Autor:
Lynn H. Pottenger, Daniel C. Kemp, Salil N. Pendse, James S. Bus, Darol E. Dodd, Harvey J. Clewell, Melvin E. Andersen, Michael B. Black, Jerry L. Campbell, Patrick D. McMullen
Publikováno v:
Toxicology and Applied Pharmacology. 332:149-158
Dichloromethane (DCM) is a lung and liver carcinogen in mice at inhalation exposures ≥ 2000 ppm. The modes of action (MOA) of these responses have been attributed to formation of genotoxic, reactive metabolite(s). Here, we examined gene expression
Autor:
Christine Palermo, Bette Meek, Jennifer Seed, Vicki L. Dellarco, Mary K. Manibusan, Chris R. Kirman, Michael L. Dourson, Lynn H. Pottenger, Jennifer E. Foreman, Richard A. Becker, Igor Linkov, Rita Schoeny, Joel M. Kronenberg
Publikováno v:
Regulatory Toxicology and Pharmacology. 86:205-220
The evolved World Health Organization/International Programme on Chemical Safety mode of action (MOA) framework provides a structure for evaluating evidence in pathways of causally linked key events (KE) leading to adverse health effects. Although em
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 103
Methyl Chloride (MeCl; Chloromethane) is a high production volume chemical (>1000 t/a) and is used as an industrial solvent. Based on cardiac lesions reported in developmental toxicity studies in mice, but not in rats, manufacturers decided to classi
Autor:
Emiel Rorije, David Kirkland, Jennifer Y. Tanir, Kerry L. Dearfield, Mirjam Luijten, Albert P. Li, Rosalie K. Elespuru, Errol Zeiger, Carole L. Yauk, Véronique Thybaud, Lynn H. Pottenger, Francesco Marchetti, George R. Douglas, Jeffrey C. Bemis, Jan van Benthem, George E. Johnson, B. Bhaskar Gollapudi, Matthew J. LeBaron, R. Daniel Benz
Publikováno v:
Environmental and Molecular Mutagenesis. 58:264-283
For several decades, regulatory testing schemes for genetic damage have been standardized where the tests being utilized examined mutations and structural and numerical chromosomal damage. This has served the genetic toxicity community well when most
Autor:
George M. Gray, Lynn H. Pottenger, Patricia Nance, Susan L. Santos, Michael L. Dourson, Roberta L. Grant, Nancy B. Beck, Ted W. Simon, R. Jeffrey Lewis, Christopher R. Kirman, William H. Farland, Judy S. LaKind, Neeraja K. Erraguntla, Richard A. Becker, Stephanie Shirley
Publikováno v:
Environment International, Vol 89, Iss, Pp 110-128 (2016)
Single point estimates of human health hazard/toxicity values such as a reference dose (RfD) are generally used in chemical hazard and risk assessment programs for assessing potential risks associated with site- or use-specific exposures. The resulti