Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lynn H. Lee"'
Autor:
Svetlana S. Itskovich, Arun Gurunathan, Jason Clark, Matthew Burwinkel, Mark Wunderlich, Mikaela R. Berger, Aishwarya Kulkarni, Kashish Chetal, Meenakshi Venkatasubramanian, Nathan Salomonis, Ashish R. Kumar, Lynn H. Lee
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The alternative splicing regulator MBNL1 is overexpressed in MLL-rearranged leukaemia. Here, the authors show that MBNL1-mediated alternative splicing leads to a specific splicing profile in MLL-rearranged leukaemia and loss or inhibition of MBNL1 im
Externí odkaz:
https://doaj.org/article/1b153388c9a248a7aa9ef84624fc49dd
Autor:
Gabriel Gracia-Maldonado, Jason Clark, Matthew Burwinkel, Brenay Greenslade, Mark Wunderlich, Nathan Salomonis, Dario Leone, Evelina Gatti, Philippe Pierre, Ashish R. Kumar, Lynn H. Lee
Publikováno v:
Haematologica, Vol 107, Iss 4 (2021)
Although great advances have been made in understanding the pathobiology of mixed lineage leukemia-rearranged (MLL-r) leukemias, therapies for this leukemia have remained limited, and clinical outcomes remain bleak. In order to identify novel targets
Externí odkaz:
https://doaj.org/article/3a5c9617d03f4777999cbd2fb6ef2278
Autor:
Svetlana S. Itskovich, Arun Gurunathan, Jason Clark, Matthew Burwinkel, Mark Wunderlich, Mikaela R. Berger, Aishwarya Kulkarni, Kashish Chetal, Meenakshi Venkatasubramanian, Nathan Salomonis, Ashish R. Kumar, Lynn H. Lee
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/ba74c9fed4634a3e88f1f48b840ed29b
Autor:
Kimberly Stegmaier, Jérôme Tamburini, Anthony Letai, Mark Wunderlich, Lynn H. Lee, Federica Piccioni, Scott T. Younger, Joseph D. Mancias, Jeremy A. Ryan, Biniam Adane, Sarah Mouche, Thelma Mashaka, Amy Saur Conway, Amanda L. Robichaud, Guillaume Kugener, Caroline S. Wechsler, Miljan Kuljanin, Neekesh V. Dharia, Bo Kyung A. Seong, Nastassja K. Scheidegger, Clément Larrue, Shan Lin
Supplementary Tables from An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a00231f66c2f1f2d618c874e239af4
https://doi.org/10.1158/2159-8290.22540225.v1
https://doi.org/10.1158/2159-8290.22540225.v1
Autor:
Kimberly Stegmaier, Jérôme Tamburini, Anthony Letai, Mark Wunderlich, Lynn H. Lee, Federica Piccioni, Scott T. Younger, Joseph D. Mancias, Jeremy A. Ryan, Biniam Adane, Sarah Mouche, Thelma Mashaka, Amy Saur Conway, Amanda L. Robichaud, Guillaume Kugener, Caroline S. Wechsler, Miljan Kuljanin, Neekesh V. Dharia, Bo Kyung A. Seong, Nastassja K. Scheidegger, Clément Larrue, Shan Lin
CRISPR–Cas9-based genetic screens have successfully identified cell type–dependent liabilities in cancer, including acute myeloid leukemia (AML), a devastating hematologic malignancy with poor overall survival. Because most of these screens have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8b74c36b48f4b32ecfaef81a5921cb
https://doi.org/10.1158/2159-8290.c.6549322
https://doi.org/10.1158/2159-8290.c.6549322
Autor:
Kimberly Stegmaier, Jérôme Tamburini, Anthony Letai, Mark Wunderlich, Lynn H. Lee, Federica Piccioni, Scott T. Younger, Joseph D. Mancias, Jeremy A. Ryan, Biniam Adane, Sarah Mouche, Thelma Mashaka, Amy Saur Conway, Amanda L. Robichaud, Guillaume Kugener, Caroline S. Wechsler, Miljan Kuljanin, Neekesh V. Dharia, Bo Kyung A. Seong, Nastassja K. Scheidegger, Clément Larrue, Shan Lin
Supplementary Data from An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d609241f021048a4e574176ba23569
https://doi.org/10.1158/2159-8290.22540234
https://doi.org/10.1158/2159-8290.22540234
Autor:
Tomoya Muto, Maria Guillamot, Jennifer Yeung, Jing Fang, Joshua Bennett, Bettina Nadorp, Audrey Lasry, Luna Zea Redondo, Kwangmin Choi, Yixiao Gong, Callum S. Walker, Kathleen Hueneman, Lyndsey C. Bolanos, Laura Barreyro, Lynn H. Lee, Kenneth D. Greis, Nikita Vasyliev, Alireza Khodadadi-Jamayran, Evgeny Nudler, Amaia Lujambio, Scott W. Lowe, Iannis Aifantis, Daniel T. Starczynowski
Publikováno v:
Cell stem cell. 29(2)
Clonal hematopoiesis (CH) is an aging-associated condition characterized by the clonal outgrowth of pre-leukemic cells that acquire specific mutations. Although individuals with CH are healthy, they are at an increased risk of developing myeloid mali