Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Lynn F. Ten Eyck"'
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 7 (2009)
Externí odkaz:
https://doaj.org/article/3d5be3638fc64e72af50a99dd3ea1d4e
Autor:
Jason C. Del Rio, Susan S. Taylor, Lynn F. Ten Eyck, Jian Wu, Jessica G.H. Bruystens, Alexandr P. Kornev, Tsan-Wen Lu
Publikováno v:
The Journal of Biological Chemistry
It is difficult to imagine where the signaling community would be today without the Protein Data Bank. This visionary resource, established in the 1970s, has been an essential partner for sharing information between academics and industry for over 3
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 4, p e1000056 (2008)
Cyclic nucleotides (cAMP and cGMP) regulate multiple intracellular processes and are thus of a great general interest for molecular and structural biologists. To study the allosteric mechanism of different cyclic nucleotide binding (CNB) domains, we
Externí odkaz:
https://doaj.org/article/ce88f0f6918647ac8c56b2fa95e8788c
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 81:2106-2118
Protein-DNA interactions are essential for many biological processes, X-ray crystallography can provide high-resolution structures, but protein-DNA complexes are difficult to crystallize and typically contain only small DNA fragments. Thus, there is
Autor:
Marc-André Elsliger, Qingping Xu, Mark Levisson, Sjon Hendriks, Frank von Delft, Gye Won Han, Pietro Roversi, Marc C. Deller, Daniel McMullan, Scott A. Lesley, Ashley M. Deacon, Servé W. M. Kengen, Ian A. Wilson, Lynn F. Ten Eyck, Mitchell D. Miller, Peter Biely, Andreas Kreusch, John van der Oost, Claus Flensburg
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 80:1545-1559
TM0077 from Thermotoga maritima is a member of the carbohydrate esterase family 7 and is active on a variety of acetylated compounds, including cephalosporin C. TM0077 esterase activity is confined to short-chain acyl esters (C2-C3), and is optimal a
Publikováno v:
Journal of chemical theory and computation. 1(1)
We have formulated the Energy by Linear Superposition of Corrections Approximation (ELSCA) for estimating the electrostatic and apolar solvation energy of bringing two proteins into close proximity or into contact as defined by the linearized Poisson
Autor:
Alexandr P. Kornev, Lynn F. Ten Eyck, Elaine E. Thompson, Susan S. Taylor, Choel Kim, Natarajan Kannan
Publikováno v:
Protein Science. 18:2016-2026
Identifying conserved pockets on the surfaces of a family of proteins can provide insight into conserved geometric features and sites of protein–protein interaction. Here we describe mapping and comparison of the surfaces of aligned crystallographi
Publikováno v:
Proceedings of the National Academy of Sciences. 105:14377-14382
Structures of set of serine-threonine and tyrosine kinases were investigated by the recently developed bioinformatics tool Local Spatial Patterns (LSP) alignment. We report a set of conserved motifs comprised mostly of hydrophobic residues. These res
Autor:
Elizabeth A. Komives, Ganesh S. Anand, Susan S. Taylor, Lynn F. Ten Eyck, Simon H. J. Brown, Matthew Hotchko
Publikováno v:
Journal of Molecular Biology. 374:487-499
The two isoforms (RI and RII) of the regulatory (R) subunit of cAMP-dependent protein kinase or protein kinase A (PKA) are similar in sequence yet have different biochemical properties and physiological functions. To further understand the molecular
Autor:
Jie Yang, Madhusudan, Lynn F. Ten Eyck, Natarajan Kannan, Nguyen-Huu Xuong, Jian Wu, Susan S. Taylor
Publikováno v:
Protein Science. 14:2871-2879
Glu230, one of the acidic residues that cluster around the active site of the catalytic subunit of cAMP-dependent protein kinase, plays an important role in substrate recognition. Specifically, its side chain forms a direct salt-bridge interaction wi