Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Lynn E Connolly"'
1
Akademický článek
Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution.
Autor: Holly R Ramage, Lynn E Connolly, Jeffery S Cox
Publikováno v: PLoS Genetics, Vol 5, Iss 12, p e1000767 (2009)
Toxin-antitoxin (TA) systems, stress-responsive genetic elements ubiquitous in microbial genomes, are unusually abundant in the major human pathogen Mycobacterium tuberculosis. Why M. tuberculosis has so many TA systems and what role they play in the
Externí odkaz: https://doaj.org/article/7c24f51ba05d404b848f86ea7ec61f1e
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2
Akademický článek
Why is long-term therapy required to cure tuberculosis?
Autor: Lynn E Connolly, Paul H Edelstein, Lalita Ramakrishnan
Publikováno v: PLoS Medicine, Vol 4, Iss 3, p e120 (2007)
Externí odkaz: https://doaj.org/article/a8d5b34c3a43432eb974897127a8848a
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3
1086. A Whole-Body Quantitative System Pharmacology Physiologically-Based Pharmacokinetic (QSP/PBPK) Model that a priori Predicts Intramuscular (IM) Pharmacokinetics of ADG20: an Extended Half-life Monoclonal Antibody Being Developed for the Treatment and Prevention of Coronavirus Disease (COVID-19)
Autor: Scott A Van Wart, Evan D Tarbell, Donald E Mager, Dhaval K Shah, Lynn E Connolly, Paul G Ambrose
Publikováno v: Open Forum Infectious Diseases. 8:S634-S635
Background ADG20 is a fully human IgG1 monoclonal antibody engineered to have potent and broad neutralization against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and additional SARS-like CoVs with pandemic potential and an extended h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8af8ac639a490e73409d614fbe7279b4
https://doi.org/10.1093/ofid/ofab466.1280
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4
ARGONAUT II study of the in vitro activity of plazomicin against carbapenemase-producing klebsiella pneumoniae
Autor: Kevin M. Krause, Richard C. White, Lynn E. Connolly, Roshan D'Souza, Andrea M. Hujer, Cesar A. Arias, Susan D. Rudin, Kevin Nguyen, David van Duin, Ayman M. Abdelhamed, Lauren M. Brinkac, Laura J. Rojas, Derrick E. Fouts, Kristine M. Hujer, Robin Patel, Daniel D. Rhoads, Barry N. Kreiswirth, Michael R. Jacobs, Robert A. Bonomo, T. Nicholas Domitrovic, Indresh Singh, Caryn E. Good
Publikováno v: Repositorio U. El Bosque
Universidad El Bosque
instacron:Universidad El Bosque
Antimicrob Agents Chemother
Plazomicin was tested against 697 recently acquired carbapenem-resistant Klebsiella pneumoniae isolates from the Great Lakes region of the United States. Plazomicin MIC 50 and MIC 90 values were 0.25 and 1 mg/liter, respectively; 680 isolates (97.6%)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea460cd662d06e5f65455997fb7374e
https://repositorio.unbosque.edu.co
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5
Plazomicin for Infections Caused by Carbapenem-Resistant Enterobacteriaceae
Autor: James A, McKinnell, Jamie P, Dwyer, George H, Talbot, Lynn E, Connolly, Ian, Friedland, Alex, Smith, Adrian M, Jubb, Alisa W, Serio, Kevin M, Krause, George L, Daikos, Loren, Miller
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Plazomicin for Severe Resistant Infection This report compared plazomicin with colistin for the treatment of severe (bloodstream or pneumonia) infection with carbapenem-resistant Enterobacteriaceae...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ebb814712dbac1d6ee83fd1b614cfa
https://doi.org/10.1056/nejmc1807634
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7
Once-Daily Plazomicin for Complicated Urinary Tract Infections
Autor: Florian M E, Wagenlehner, Daniel J, Cloutier, Allison S, Komirenko, Deborah S, Cebrik, Kevin M, Krause, Tiffany R, Keepers, Lynn E, Connolly, Loren G, Miller, Ian, Friedland, Jamie P, Dwyer, Robert, Poirier
Publikováno v: The New England journal of medicine. 380(8)
The increasing multidrug resistance among gram-negative uropathogens necessitates new treatments for serious infections. Plazomicin is an aminoglycoside with bactericidal activity against multidrug-resistant (including carbapenem-resistant) Enterobac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f420104a5ea4dd1ccf657b1feac3c6
https://pubmed.ncbi.nlm.nih.gov/31398750
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8
631. Preliminary safety and pharmacokinetic profile of VIR-2482: a monoclonal antibody for the prevention of influenza A illness
Autor: Deborah S Cebrik, Aurelio Bonavia, Jennifer Sager, Erik Mogalian, David K. Hong, Marie Christine Fanget, Paul Griffin, Lynn E. Connolly
Publikováno v: Open Forum Infectious Diseases
Background VIR-2482 is a fully human immunoglobulin G1(IgG) monoclonal antibody (mAb) directed against a highly-conserved epitope in the influenza A hemagglutinin stem region and is in clinical development for the prevention of influenza A illness. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39225218657372aa12588a9ee2819e65
http://europepmc.org/articles/PMC7776649
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9
A Multicenter, Randomized, Double-Blind, Phase 2 Study of the Efficacy and Safety of Plazomicin Compared with Levofloxacin in the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis
Autor: Deborah S Cebrik, Eliana S. Armstrong, Loren G. Miller, Valerie Riddle, Lynn E. Connolly
Publikováno v: Antimicrobial Agents and Chemotherapy. 62
Increasing antimicrobial resistance among uropathogens limits treatment options for patients with complicated urinary tract infection (cUTI). Plazomicin, a new aminoglycoside, has in vitro activity against multidrug-resistant Enterobacteriaceae , inc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1095bcd1a926d0aab4083dd884a9b1c0
https://doi.org/10.1128/aac.01989-17
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10
Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion
Autor: Xueming Li, Dustin Dovala, Oren S. Rosenberg, Yifan Cheng, James M. Holton, Jeffery S. Cox, Janet Finer-Moore, Robert M. Stroud, Anastasia Bendebury, Lynn E. Connolly
Publikováno v: Rosenberg, Oren S.; Dovala, Dustin; Li, Xueming; Connolly, Lynn; Bendebury, Anastasia; Finer-Moore, Janet; et al.(2015). Substrates Control Multimerization and Activation of the Multi-domain ATPase Motor of Type VII Secretion. Cell, 161(3), 501-512. UC Office of the President: Multicampus Research Programs and Initiatives (MRPI); a funding opportunity through UC Research Initiatives (UCRI). Retrieved from: http://www.escholarship.org/uc/item/9w08r6m6
Rosenberg, Oren S; Dovala, Dustin; Li, Xueming; Connolly, Lynn; Bendebury, Anastasia; Finer-Moore, Janet; et al.(2015). Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion.. Cell, 161(3), 501-512. UC Office of the President: Multicampus Research Programs and Initiatives (MRPI); a funding opportunity through UC Research Initiatives (UCRI). Retrieved from: http://www.escholarship.org/uc/item/3gp8j2pc
SummaryMycobacterium tuberculosis and Staphylococcus aureus secrete virulence factors via type VII protein secretion (T7S), a system that intriguingly requires all of its secretion substrates for activity. To gain insights into T7S function, we used
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd9ab3f4f15e35ee48f07cd0ea48aae
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