Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Lynn Dufresne"'
Autor:
Richard Friesen, Lynn Dufresne, Tom Y.-H. Wu, Denis Riendeau, Yves Ducharme, Joseph A. Mancini, Myriam Salem, Christine Brideau, Sébastien Guiral, Helene Juteau, Hugo Poirier
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(23)
Microsomal prostaglandin E 2 synthase (mPGES-1) represents a potential target for novel analgesic and anti-inflammatory agents. High-throughput screening identified several leads of mPGES-1 inhibitors which were further optimized for potency and sele
Publikováno v:
Developmental dynamics : an official publication of the American Association of Anatomists. 239(4)
The chick embryo is an ideal model to study pituitary cell-type differentiation. Previous studies describing the temporal appearance of differentiated pituitary cell types in the chick embryo are contradictory. To resolve these controversies, we used
Autor:
Rino Stocco, Annette Robichaud, Paul Tawa, Deborah Slipetz, Sean Weicker, Jeanne Honsberger, Lynn Dufresne, Alex G. Therien, Hani Houshyar, Gary P. O'Neill, Christopher M. Tan, Chidambaram Ramachandran, Virginie Bernier, Josiane Lafleur, Marie-Claude Mathieu, Jean-Pierre Falgueyret, Véronique Pomerleau
Publikováno v:
American journal of respiratory cell and molecular biology. 39(1)
Interleukin 13 (IL-13) is considered to be a key driver of the development of airway allergic inflammation and remodeling leading to airway hyperresponsiveness (AHR). How precisely IL-13 leads to the development of airway inflammation, AHR, and mucus
Autor:
Lynn Dufresne, Chi-Chung Chan, Anne K. Mullen, Jocelyne Guay, Daigen Xu, Bernard Cote, Christine Brideau, Joseph A. Mancini, R. Gordon, Steven E. Rowland, Laurent P. Audoly, Yves Ducharme, Patsy Clark
Publikováno v:
European journal of pharmacology. 560(2-3)
Selective type 2 cyclooxygenase (COX-2) inhibitors are often used in preclinical studies without potency and selectivity data in the experimental species. To address this issue, we assessed a selective COX-2 inhibitor MF-tricyclic in four commonly us