Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies

Autor: Lijie Zhai, April Bell, Erik Ladomersky, Kristen L. Lauing, Lakshmi Bollu, Jeffrey A. Sosman, Bin Zhang, Jennifer D. Wu, Stephen D. Miller, Joshua J. Meeks, Rimas V. Lukas, Eugene Wyatt, Lynn Doglio, Gary E. Schiltz, Robert H. McCusker, Derek A. Wainwright

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Indoleamine 2, 3-dioxygenase 1 (IDO; IDO1; INDO) is a rate-limiting enzyme that metabolizes the essential amino acid, tryptophan, into downstream kynurenines. Canonically, the metabolic depletion of tryptophan and/or the accumulation of kynurenine is

Externí odkaz: https://doaj.org/article/739cbe66148b4c3487d236e84486ab82

Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor

Autor: Xiaomin Bao, Gloria Urciuoli, Lynn Doglio, Rajeshwar Awatramani, Junghun Kweon, Lam C. Tsoi, Caterina Missero, Hope E. Burks, Joshua A. Broussard, Eran Cohen-Barak, Sarah M. Lloyd, Lisa M. Godsel, Paul W. Harms, Jennifer L. Koetsier, Kathleen J. Green, Amber L. Huffine, Jodi L. Johnson, Marihan Hegazy, Eli Sprecher, Saki Amagai, Quinn R. Roth-Carter, William R. Swindell, Gillian Nicole Fitz, Johann E. Gudjonsson

Desmoglein 1 (Dsg1) is a cadherin restricted to stratified tissues of terrestrial vertebrates, which serve as essential physical and immune barriers. Dsg1’s importance in epidermal integrity is underscored by genetic, autoimmune and bacterial toxin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e844541f48b5062215b058211ac3c15
https://doi.org/10.1101/2020.12.01.406587

TT2016 meeting report on the 13th Transgenic Technology meeting in Prague, Czech Republic

Autor: Lynn Doglio, Jinping Luo, Jan Parker-Thornburg, Martina Crispo, Benoît Kanzler, Bruce Whitelaw, Susan Tamowski, Boris Jerchow

Publikováno v: Transgenic Research
Transgenic Research, Springer Verlag, 2016, 25 (4), pp.553-9. ⟨10.1007/s11248-016-9966-0⟩
Tamowski, S, Luo, J, Kanzler, B, Whitelaw, B, Crispo, M, Doglio, L, Jerchow, B & Parker-Thornburg, J 2016, ' TT2016 meeting report on the 13th Transgenic Technology meeting in Prague, Czech Republic ', Transgenic Research . https://doi.org/10.1007/s11248-016-9966-0

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b760b8464ec9f58701e93ec3eec96147
https://doi.org/10.1007/s11248-016-9966-0

U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia

Autor: Michael R. Pins, Ximing J. Yang, Lynn Doglio, Geoffrey M. Habermacher, Qiang Zhang, Rajiv Dhir, Liu J, Xiaoyan Cai, Wuhan Xiao, Jeffrey R. Gingrich, Zhou Wang, Ali Zhang, Hahn J

Publikováno v: Oncogene. 27:1536-1544

Upregulated gene 19 (U19)/ELL-associated factor 2 (Eaf2) is a potential human tumor suppressor that exhibits frequent allelic loss and downregulation in high-grade prostate cancer. U19/Eaf2, along with its homolog Eaf1, has been reported to regulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b56d9c3e5f267a427cfa46ee54bb85
https://doi.org/10.1038/sj.onc.1210786

GLI1 Localization in the Germinal Epithelial Cells Alternates Between Cytoplasm and Nucleus: Upregulation in Transgenic Mice Blocks Spermatogenesis in Pachytene1

Autor: Erwin Goldberg, Tim L. Kroft, Joon Won Yoon, Phillip Iannaccone, Lynn Doglio, John Patterson, David O. Walterhouse

Publikováno v: Biology of Reproduction. 65:1663-1671

The zinc finger transcription factor GLI1 is the mediator of signaling by members of the Hedgehog (Hh) family. Male mice in which Desert hedgehog (Dhh), an Hh homologue expressed in Sertoli cells of the testis, was knocked out are sterile, suggesting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3856704af6322dd0fac3e2cb891b37d
https://doi.org/10.1095/biolreprod65.6.1663