Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lynn Decarr"'
Autor:
Sethu Sankaranarayanan, Donna M Barten, Laurel Vana, Nino Devidze, Ling Yang, Gregory Cadelina, Nina Hoque, Lynn DeCarr, Stefanie Keenan, Alan Lin, Yang Cao, Bradley Snyder, Bin Zhang, Magdalena Nitla, Gregg Hirschfeld, Nestor Barrezueta, Craig Polson, Paul Wes, Vangipuram S Rangan, Angela Cacace, Charles F Albright, Jere Meredith, John Q Trojanowski, Virginia M-Y Lee, Kurt R Brunden, Michael Ahlijanian
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125614 (2015)
In Alzheimer's disease (AD), an extensive accumulation of extracellular amyloid plaques and intraneuronal tau tangles, along with neuronal loss, is evident in distinct brain regions. Staging of tau pathology by postmortem analysis of AD subjects sugg
Externí odkaz:
https://doaj.org/article/1519b91e16e24a3587dc69c274adc911
Autor:
Nicole Barucci, Herbert Ogutu, Laurel Sweet, Ronda Ott-Morgan, Louis-David Cantin, Yaxin Li, James N. Livingston, Philip Wickens, Lei Zhu, Sidney X. Liang, Jennifer Burke, Timothy B. Lowinger, Zhonghua Zhang, Bullock William H, Michelle Daly, Robert Schoenleber, Lynn Decarr, Steven Magnuson, Adrian Tersteegen, Ann Gore-Willse, Ellalahewage Kumarasinghe, Alan Olague, Jian Zhu, Marina Breuhaus, David E. Gunn, Margit L. MacDougall, Thomas H. Claus, Helana Hoover-Litty
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2869-2873
Modulation of cAMP levels has been linked to insulin secretion in preclinical animal models and in humans. The high expression of PDE-10A in pancreatic islets suggested that inhibition of this enzyme may provide the necessary modulation to elicit inc
Autor:
Kevin J. Lumb, Lynn Decarr, Stephen E. Fisk, Zahra Fathi, Thomas M. Buckholz, Stephen J. O'connor, Philip Coish, Michelle R. Mays
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:538-541
Activation of the NPY2 receptor to reduce appetite while avoiding stimulation of the NPY1 and NPY5 receptors that induce feeding provides a pharmaceutical approach to modulate food intake. The naturally occurring peptide PYY(3–36) is a nonselective
Autor:
Kevin J. Lumb, James N. Livingston, Lynn Decarr, Lucinda F. Milardo, Thomas M. Buckholz, Cathy D. Mahle, Michelle R. Mays, Thomas H. Claus, Astrid A. Ortiz
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 323(2)
Selective activation of the neuropeptide Y (NPY)2 receptor to suppress appetite provides a promising approach to obesity management. A selective NPY2 polyethylene glycol-conjugated (PEGylated) peptide agonist is described that consists of a peptide c
Autor:
Stephen E. Fisk, Michelle R. Mays, Lynn Decarr, Kevin J. Lumb, Lucinda F. Milardo, Cathy D. Mahle, and Astrid A. Ortiz, Carla M. Pellegrino, Thomas M. Buckholz
Publikováno v:
Journal of medicinal chemistry. 50(9)
Selective activation of the NPY2 receptor to suppress appetite provides an approach to obesity management. Selective NPY2 PEGylated peptide agonists are described that consist of a peptide core corresponding to residues 25-36 of PYY and a nonpeptidic
Autor:
Lynn Decarr, Kevin J. Lumb, Astrid A. Ortiz, Michelle R. Mays, Lucinda F. Milardo, Thomas M. Buckholz
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(7)
Activation of the NPY2 receptor to reduce appetite while avoiding activation of the NPY1 and NPY5 receptors that stimulate feeding provides a pharmaceutical approach to modulate food intake. The naturally occurring peptide and development candidate P