Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lynn D. Blake"'
Autor:
Paul Willis, Sherwin Mashkouri, Roman Manetsch, Alexis N. LaCrue, Jordany R. Maignan, Andrii Monastyrskyi, Debora Casandra, Tina S. Mutka, Cynthia L. Lichorowic, Raghupathi Neelarapu, Dennis E. Kyle, Lynn D. Blake, Jeremy N. Burrows
Publikováno v:
Journal of Medicinal Chemistry. 61:1450-1473
Malaria deaths have been decreasing over the last 10–15 years, with global mortality rates having fallen by 47% since 2000. While the World Health Organization (WHO) recommends the use of artemisinin-based combination therapies (ACTs) to combat mal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2176f749ffefeae0eec9181b5ef4f437
https://doi.org/10.1021/acs.jmedchem.7b00738
https://doi.org/10.1021/acs.jmedchem.7b00738
Autor:
Roman Manetsch, Tommy W. McGaha, M. Trent Kemp, Niranjan K. Namelikonda, Randy W. Larsen, Dennis E. Kyle, Lynn D. Blake, Adonis McQueen, Ala Azhari
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:4597-4600
Primaquine (PQ) is the only commercially available drug that clears dormant liver stages of malaria and blocks transmission to mosquito vectors. Although an old drug, much remains to be known about the mechanism(s) of action. Herein we develop a fluo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c3648d0921c55c32ba24e461aa4d0d
https://doi.org/10.1016/j.bmcl.2017.09.030
https://doi.org/10.1016/j.bmcl.2017.09.030
Autor:
Sasha V. Siegel, Roman Manetsch, Michael W. Shultis, Lynn D. Blake, Adonis McQueen, Abdul Kadar Shaikh, Iredia D. Iyamu, Dennis E. Kyle, Myles E. Johnson
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
Malaria-related mortality has slowly decreased over the past decade; however, eradication of malaria requires the development of new antimalarial chemotherapies that target liver stages of the parasite and combat the emergence of drug resistance. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::680ca6dfd96e7d234392b4564faa9387
https://doi.org/10.1128/aac.00689-17
https://doi.org/10.1128/aac.00689-17
Autor:
Lynn D, Blake, Myles E, Johnson, Sasha V, Siegel, Adonis, McQueen, Iredia D, Iyamu, Abdul Kadar, Shaikh, Michael W, Shultis, Roman, Manetsch, Dennis E, Kyle
Publikováno v:
Antimicrobial agents and chemotherapy. 61(8)
Malaria-related mortality has slowly decreased over the past decade; however, eradication of malaria requires the development of new antimalarial chemotherapies that target liver stages of the parasite and combat the emergence of drug resistance. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2369cf5618a6d2afb410dc24c509db95
https://pubmed.ncbi.nlm.nih.gov/28584157
https://pubmed.ncbi.nlm.nih.gov/28584157
Autor:
Roman Manetsch, Paul Willis, Debora Casandra, James Giarrusso, Dennis E. Kyle, Alexis N. LaCrue, Cynthia L. Lichorowic, Jeremy N. Burrows, Jordany R. Maignan, Tina S. Mutka, Lynn D. Blake
Publikováno v:
J Med Chem
Malaria is estimated to have caused 584,000 deaths and 198 million cases of the disease globally in 2013. Though mortality rates are down 47% globally since 2000 and significant progress has been made in the quest for eradication, reported occurrence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6286ddf57c716f8d2510afef5537ed1
https://pubmed.ncbi.nlm.nih.gov/27291102
https://pubmed.ncbi.nlm.nih.gov/27291102