Substrate specificity of lysophosphatidic acid acyltransferase β—evidence from membrane and whole cell assays

Autor: David Hollenback, Lynn Bonham, Laura Law, Eddie Rossnagle, Lisa Romero, Heather Carew, Christopher K. Tompkins, David W. Leung, Jack W. Singer, Thayer White

Publikováno v: Journal of Lipid Research, Vol 47, Iss 3, Pp 593-604 (2006)

Membranes of mammalian cells contain lysophosphatidic acid acyltransferase (LPAAT) activities that catalyze the acylation of sn-1-acyl lysophosphatidic acid (lysoPA) to form phosphatidic acid. As the biological roles and biochemical properties of the

Externí odkaz: https://doaj.org/article/c9e298f004694354859270dc9a515b8e

Supplementary Materials, Figures 1-4, Tables 1-2 from Antileukemic Activity of Lysophosphatidic Acid Acyltransferase-β Inhibitor CT32228 in Chronic Myelogenous Leukemia Sensitive and Resistant to Imatinib

Autor: Michael W. Deininger, Brian J. Druker, Junia V. Melo, Jack W. Singer, David Hollenback, Lynn Bonham, Peter de Vries, Nicolai Härtel, Shadmer Demehri, Taiping Jia, Paul La Rosée

Supplementary Materials, Figures 1-4, Tables 1-2 from Antileukemic Activity of Lysophosphatidic Acid Acyltransferase-β Inhibitor CT32228 in Chronic Myelogenous Leukemia Sensitive and Resistant to Imatinib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1723a7736fdf19c259754d3d2763f722
https://doi.org/10.1158/1078-0432.22441543.v1

An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation

Autor: Lynn Bonham, Raymond J. Paxton, Stuart D. Olver, Brandon J. Wainwright, Rachel D. Kuns, Kelli P. A. MacDonald, Geoffrey R. Hill, David A. Hume, Andrew D. Clouston, Neil C. Raffelt, James S. Palmer, Douglas P. Cerretti, Stephen L. Cronau, D Branstetter, Allison R. Pettit, Elke Seppanen, Jeffrey Smith

Publikováno v: MacDonald, K P A, Palmer, J S, Cronau, S, Seppanen, E, Olver, S, Raffelt, N C, Kuns, R, Pettit, A R, Clouston, A, Wainwright, B, Branstetter, D, Smith, J, Paxton, R J, Cerretti, D P, Bonham, L, Hill, G R & Hume, D A 2010, ' An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue-and tumor-associated macrophages but does not inhibit inflammation ', Blood, vol. 116, no. 19, pp. 3955-3963 . https://doi.org/10.1182/blood-2010-02-266296

The development of the mononuclear phagocyte system requires macrophage colony-stimulating factor (CSF-1) signaling through the CSF-1 receptor (CSF1R, CD115). We examined the effect of an antibody against CSF1R on macrophage homeostasis and function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f5f0a940ae16a259a7b3ced226a7f7
https://doi.org/10.1182/blood-2010-02-266296

Effect of lysophosphatidic acid acyltransferase-β inhibition in acute leukemia

Autor: Beverly S. Mitchell, Jack W. Singer, Lynn Bonham, Karen N. Hogan, Yanshan Ji, David Hollenback, Michael Gregory Douvas

Publikováno v: Leukemia Research. 30:1027-1036

Phosphatidic acid (PA) is an important component of mammalian target of rapamycin (mTOR) signaling and in the recruitment of Raf to the cell membrane. PA can be produced by several mechanisms, including by a series of lysophosphatidic acid acyl trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d320fe559a4cd88802827ec51a0c288
https://doi.org/10.1016/j.leukres.2005.11.018

Lysophosphatidic Acid Acyltransferase-β Is a Prognostic Marker and Therapeutic Target in Gynecologic Malignancies

Autor: Gregory M. Springett, Chia Ma, Jack W. Singer, Irina Linkov, Amanda J. Hummer, Lynn Bonham, Hiroaki Kawasaki, Dipika Misra, David R. Spriggs, Gabriella Pezzoni, Jakob Dupont, Robert A. Soslow, Stefano Di Giovine

Publikováno v: Cancer Research. 65:9415-9425

Lysophosphatidic acid, the substrate for lysophosphatidic acid acyltransferase β (LPAAT-β), is a well-studied autocrine/paracrine signaling molecule that is secreted by ovarian cancer cells and is found at elevated levels in the blood and ascites f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac56dfd0b184e07605e8cae6424e676
https://doi.org/10.1158/0008-5472.can-05-0516