Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Lynn Bedford"'
Autor:
Aslihan Ugun-Klusek, Theodosis S. Theodosi, Julia C. Fitzgerald, Florence Burté, Christoph Ufer, David J. Boocock, Patrick Yu-Wai-Man, Lynn Bedford, E. Ellen Billett
Publikováno v:
Redox Biology, Vol 20, Iss , Pp 167-181 (2019)
Monoamine oxidases (MAOs) are located on the outer mitochondrial membrane and are drug targets for the treatment of neurological disorders. MAOs control the levels of neurotransmitters in the brain via oxidative deamination and contribute to reactive
Externí odkaz:
https://doaj.org/article/6433d8e6f4db46e580b30b0875bd1505
Autor:
Amaia M Erdozain, Benito Morentin, Lynn Bedford, Emma King, David Tooth, Charlotte Brewer, Declan Wayne, Laura Johnson, Henry K Gerdes, Peter Wigmore, Luis F Callado, Wayne G Carter
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93586 (2014)
Chronic excessive alcohol intoxications evoke cumulative damage to tissues and organs. We examined prefrontal cortex (Brodmann's area (BA) 9) from 20 human alcoholics and 20 age, gender, and postmortem delay matched control subjects. H & E staining a
Externí odkaz:
https://doaj.org/article/566b646e642a474da384912d47f59d27
Autor:
Simon M L Paine, Glenn Anderson, Karen Bedford, Karen Lawler, R John Mayer, James Lowe, Lynn Bedford
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54711 (2013)
Parkinson's disease (PD) is characterized by the progressive degeneration of substantia nigra pars compacta (SNpc) dopaminergic neurones and the formation of Lewy bodies (LB) in a proportion of the remaining neurones. α-synuclein is the main compone
Externí odkaz:
https://doaj.org/article/a72655997996431aab745e72983c18c0
Autor:
Jing Fang, Megan T. Lewno, Huabo Su, Taixing Cui, Nirmal Parajuli, Wenjuan Wang, Jianqiu Zou, Penglong Wu, Bo Pan, Jinbao Liu, R. John Mayer, Zongwen Tian, Xuejun Wang, Lynn Bedford, Jie Li
Publikováno v:
Autophagy
Rationale: The ubiquitin-proteasome system (UPS) and the autophagic-lysosomal pathway are pivotal to proteostasis. Targeting these pathways is emerging as an attractive strategy for treating cancer. However, a significant proportion of patients who r
Publikováno v:
Higher Education Pedagogies, Vol 4, Iss 1, Pp 262-283 (2019)
Presentations assessing public speaking skills are common features of undergraduate curricula. Performance feedback has often been traditionally limited to staff, yet students acting as peer assessors can also be a useful feedback source. Additionall
Autor:
Patrick Yu-Wai-Man, Christoph Ufer, Lynn Bedford, David J. Boocock, Theodosis S. Theodosi, Aslihan Ugun-Klusek, Julia C. Fitzgerald, E. Ellen Billett, Florence Burté
Publikováno v:
Redox Biology, Vol 20, Iss, Pp 167-181 (2019)
Redox Biology 20, 167-181 (2019). doi:10.1016/j.redox.2018.10.003
Redox Biology
Redox Biology 20, 167-181 (2019). doi:10.1016/j.redox.2018.10.003
Redox Biology
Monoamine oxidases (MAOs) are located on the outer mitochondrial membrane and are drug targets for the treatment of neurological disorders. MAOs control the levels of neurotransmitters in the brain via oxidative deamination and contribute to reactive
Autor:
Xuejun Wang, Jing Fang, R. John Mayer, Bo Pan, Lynn Bedford, Megan T. Lewno, Nirmal Parajuli, Penglong Wu, Huabo Su, Zongwen Tian, Jinbao Liu, Taixing Cui, Jie Li
RationaleThe ubiquitin-proteasome system (UPS) and the autophagic-lysosomal pathway (ALP) are pivotal to proteostasis. Targeting these pathways is emerging as an attractive strategy for treating cancer. However, a significant proportion of patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02722129be154703e66cb353161e6bd8
https://doi.org/10.1101/2019.12.27.889519
https://doi.org/10.1101/2019.12.27.889519
Autor:
Aslihan, Ugun-Klusek, Michael H, Tatham, Jamal, Elkharaz, Dumitru, Constantin-Teodosiu, Karen, Lawler, Hala, Mohamed, Simon M L, Paine, Glen, Anderson, R, John Mayer, James, Lowe, E, Ellen Billett, Lynn, Bedford
Publikováno v:
Cell Death & Disease
The ubiquitin–proteasome system (UPS) and macroautophagy (autophagy) are central to normal proteostasis and interdependent in that autophagy is known to compensate for the UPS to alleviate ensuing proteotoxic stress that impairs cell function. UPS
Publikováno v:
Neuroscience Letters. 521:130-135
The ubiquitin proteasome system (UPS) is a fundamental cellular pathway, degrading most unwanted intracellular soluble proteins. Dysfunction of the UPS has been associated with normal aging as well as various age-related pathological conditions, incl
Autor:
David M. A. Mann, John E. Mayer, Adam R. Cole, Bettina Platt, Lidy van Aalten, Lynn Bedford, Alessia Usardi, Florian Plattner, Ritchie Williamson, David R. Howlett, Calum Sutherland
Publikováno v:
Journal of Alzheimer's Disease. 27:615-625
Collapsin response mediator protein 2 (CRMP2) is an abundant brain-enriched protein that regulates neurite outgrowth. It is phosphorylated by Cdk5 and GSK3, and these modifications are abnormally high in the brains of Alzheimer's disease (AD) patient