Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Lynn A. Beer"'
Autor:
Lei Guan, Bin Wu, Ting Li, Lynn A. Beer, Gaurav Sharma, Mingyue Li, Chin Nien Lee, Shujing Liu, Changsong Yang, Lili Huang, Dennie T. Frederick, Genevieve M. Boland, Guangcan Shao, Tatyana M. Svitkina, Kathy Q. Cai, Fangping Chen, Meng-Qiu Dong, Gordon B. Mills, Lynn M. Schuchter, Giorgos C. Karakousis, Tara C. Mitchell, Keith T. Flaherty, David W. Speicher, Youhai H. Chen, Meenhard Herlyn, Ravi K. Amaravadi, Xiaowei Xu, Wei Guo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Lack of CD8+ T-cell infiltration into solid tumors is associated with poor responsiveness to immune checkpoint therapy (ICT). Here, the authors show that blocking the phosphorylation of HRS to reduce the induction of immunosuppressive exosomes promot
Externí odkaz:
https://doaj.org/article/718e304323ab40bb82fc54fc7895e125
Autor:
Lynn A. Beer, Suneeta Senapati, Mary D. Sammel, Kurt T. Barnhart, Courtney A. Schreiber, David W. Speicher
Publikováno v:
Reproductive Biology and Endocrinology, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background In early pregnancy, differentiating between a normal intrauterine pregnancy (IUP) and abnormal gestations including early pregnancy loss (EPL) or ectopic pregnancy (EP) is a major clinical challenge when ultrasound is not yet diag
Externí odkaz:
https://doaj.org/article/3ffea58e4c764846b9d7f29b2a3914ce
Autor:
Lynn A Beer, Huan Wang, Hsin-Yao Tang, Zhijun Cao, Tony Chang-Wong, Janos L Tanyi, Rugang Zhang, Qin Liu, David W Speicher
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60129 (2013)
The most cancer-specific biomarkers in blood are likely to be proteins shed directly by the tumor rather than less specific inflammatory or other host responses. The use of xenograft mouse models together with in-depth proteome analysis for identific
Externí odkaz:
https://doaj.org/article/f788ca2c8ad74292bdf1c1e79875fe56
Autor:
Peter Hembach, Aaron R. Goldman, Lynn A. Beer, David W. Speicher, Delaine Zayas‐Bazan, Hsin-Yao Tang
Publikováno v:
Curr Protoc Protein Sci
This article describes processing of protein samples using 1D SDS gels prior to protease digestion for proteomics workflows that subsequently utilize reversed-phase nanocapillary ultra-high-pressure liquid chromatography (LC) coupled to tandem mass s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70189b851ef1418a9ceb39e3990211c5
https://europepmc.org/articles/PMC6653605/
https://europepmc.org/articles/PMC6653605/
Autor:
Bonnie Ky, Susan M. Domchek, David W. Speicher, Andrew V. Kossenkov, Qin Liu, Eline T. Luning Prak, Lynn A. Beer
Publikováno v:
Circulation Research. 119:1135-1144
Rationale: There is a critical need to develop robust, mechanistic strategies to identify patients at increased risk of cancer therapeutics–related cardiac dysfunction (CTRCD). Objective: We aimed to discover new biomarkers associated with doxorubi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de02a91ebb9203c848e0281aef5fd949
https://doi.org/10.1161/circresaha.116.309004
https://doi.org/10.1161/circresaha.116.309004
Autor:
David W. Speicher, Lynn A. Beer
Publikováno v:
Current protocols in protein science. 91
The most commonly used types of gels for separating proteins are SDS gels either in a 1-D format or as the second dimension of various 2-D separations, and the most common methods of visualizing proteins in these gels use protein binding dyes after f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7eceb18e02e161c7e11d488d29fce7
https://pubmed.ncbi.nlm.nih.gov/29516479
https://pubmed.ncbi.nlm.nih.gov/29516479
Publikováno v:
Methods in Molecular Biology ISBN: 9781493970568
Identification of cancer and other disease biomarkers in human plasma has been exceptionally challenging due to the complex nature of plasma and the presence of a moderate number of high- and medium-abundance proteins which mask low-abundance protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789994abec53fe9bae29bfc97e3ad6b5
https://doi.org/10.1007/978-1-4939-7057-5_7
https://doi.org/10.1007/978-1-4939-7057-5_7
Publikováno v:
Methods in Molecular Biology ISBN: 9781493970568
One strategy for improving the throughput of human plasma proteomics discovery analysis while maintaining good depth of analysis is to multiplex using isobaric tags. At present, the greatest multiplexing that is commercially available uses the TMT10p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b68d0b51141e75b21d046965f28851
https://europepmc.org/articles/PMC5558196/
https://europepmc.org/articles/PMC5558196/
Publikováno v:
Methods in Molecular Biology ISBN: 9781493970568
Mass spectrometry (MS)- based quantitation of plasma proteomes is challenging due to the extremely wide dynamic range and molecular heterogeneity of plasma samples. However, recent advances in technology, MS-instrumentation, and bioinformatics have e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01199f3109bd077fd442976aac6b89e6
https://doi.org/10.1007/978-1-4939-7057-5_23
https://doi.org/10.1007/978-1-4939-7057-5_23
Autor:
Courtney A. Schreiber, David W. Speicher, Kurt T. Barnhart, Lynn A. Beer, Suneeta Senapati, Mary D. Sammel
Publikováno v:
Fertility and Sterility. 112:e313
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d1c62a2709db4ba85e75164da802df0
https://doi.org/10.1016/j.fertnstert.2019.07.910
https://doi.org/10.1016/j.fertnstert.2019.07.910