Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Lynn A Spruce"'
Autor:
Asif A Dar, Keisuke Sawada, Joseph M Dybas, Emily K Moser, Emma L Lewis, Eddie Park, Hossein Fazelinia, Lynn A Spruce, Hua Ding, Steven H Seeholzer, Paula M Oliver
Publikováno v:
PLoS Biology, Vol 19, Iss 2, p e3001041 (2021)
The capacity for T cells to become activated and clonally expand during pathogen invasion is pivotal for protective immunity. Our understanding of how T cell receptor (TCR) signaling prepares cells for this rapid expansion remains limited. Here we pr
Externí odkaz:
https://doaj.org/article/1ccf70c70537433581dda2a256654825
Autor:
Horia Vais, Min Wang, Karthik Mallilankaraman, Riley Payne, Chris McKennan, Jeffrey T Lock, Lynn A Spruce, Carly Fiest, Matthew Yan-lok Chan, Ian Parker, Steven H Seeholzer, J Kevin Foskett, Don-On Daniel Mak
Publikováno v:
eLife, Vol 9 (2020)
Modulating cytoplasmic Ca2+ concentration ([Ca2+]i) by endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptor (InsP3R) Ca2+-release channels is a universal signaling pathway that regulates numerous cell-physiological processes. Wh
Externí odkaz:
https://doaj.org/article/dd23c45a2e9c46ebb92e8492d4b3087c
Autor:
Asif A. Dar, Dale D. Kim, Scott M. Gordon, Kathleen Klinzing, Siera Rosen, Ipsita Guha, Nadia Porter, Yohaniz Ortega, Katherine S. Forsyth, Jennifer Roof, Hossein Fazelinia, Lynn A. Spruce, Laurence C. Eisenlohr, Edward M. Behrens, Paula M. Oliver
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract During infection, virus-specific CD8+ T cells undergo rapid bursts of proliferation and differentiate into effector cells that kill virus-infected cells and reduce viral load. This rapid clonal expansion can put T cells at significant risk f
Externí odkaz:
https://doaj.org/article/13ee6ca256cb4b35a160900e56452abc
Autor:
Eui Tae Kim, Kathryn L. Roche, Katarzyna Kulej, Lynn A. Spruce, Steven H. Seeholzer, Donald M. Coen, Felipe Diaz-Griffero, Eain A. Murphy, Matthew D. Weitzman
Publikováno v:
Cell Reports, Vol 28, Iss 2, Pp 434-448.e6 (2019)
Summary: Cellular SAMHD1 inhibits replication of many viruses by limiting intracellular deoxynucleoside triphosphate (dNTP) pools. We investigate the influence of SAMHD1 on human cytomegalovirus (HCMV). During HCMV infection, we observe SAMHD1 induct
Externí odkaz:
https://doaj.org/article/1f83d63d11fa48acadd08dbdb7e37633
Autor:
Nadir Yehya, Hossein Fazelinia, Deanne M. Taylor, Gladys G. Lawrence, Lynn A. Spruce, Jill M. Thompson, Susan S. Margulies, Steven H. Seeholzer, G. Scott Worthen
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Both sepsis and acute respiratory distress syndrome (ARDS) rely on imprecise clinical definitions leading to heterogeneity, which has contributed to negative trials. Because circulating protein/DNA complexes have been implicated in sepsis and ARDS, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fee87e66fb07e1e4d1862cd61420b4
https://doi.org/10.1152/ajplung.00164.2021
https://doi.org/10.1152/ajplung.00164.2021
Autor:
Claire E. O’Leary, Christopher R. Riling, Lynn A. Spruce, Hua Ding, Suresh Kumar, Guoping Deng, Yuhong Liu, Steven H. Seeholzer, Paula M. Oliver
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Ndfip1 is an activator of Itch E3 ubiquitin ligase that limits T cell activation. Here the authors identify Jak1 in a proteomic screen for Ndfip dependent substrates, and show that Ndfip1/2 double-deficient T cells have reduced degradation of Jak1 an
Externí odkaz:
https://doaj.org/article/db42816efdd94bf7b6b714a9b6e7cec3
Autor:
Scarlett Y. Yang, Katharina E. Hayer, Hossein Fazelinia, Lynn A. Spruce, Mukta Asnani, Kathryn L. Black, Ammar S. Naqvi, Vinodh Pillai, Yoseph Barash, Kojo S. J. Elenitoba-Johnson, Andrei Thomas-Tikhonenko
Publikováno v:
Blood advances.
Noncanonical exon usage plays many important roles in cellular phenotypes, but its contribution to human B-cell development remains sketchily understood. To fill this gap, we collected various B-cell fractions from bone marrow (BM) and tonsil donors,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94e34bc14d21ff25925f578f52bec7d
https://pubmed.ncbi.nlm.nih.gov/36322817
https://pubmed.ncbi.nlm.nih.gov/36322817
Autor:
G. Scott Worthen, Ning Dai, Andrew J. Paris, Lynn A. Spruce, Steven H. Seeholzer, Joseph H. Oved, Ping Wang, Mortimer Poncz, Kandace Gollomp, Kathryn M Rubey
Publikováno v:
Blood. 137:392-397
Neutrophils are critical mediators of host defense in pathogen-induced and sterile inflammation. Excessive neutrophil activation has been associated with increased host pathology through collateral organ damage. The beneficial aspects of neutrophil a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8e81de06fe0d72761a5463dc5b190d
https://doi.org/10.1182/blood.2020005505
https://doi.org/10.1182/blood.2020005505
Publikováno v:
Blood. 140:2844-2845
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32666061e9bf9fc196d400bc9e86005e
https://doi.org/10.1182/blood-2022-159793
https://doi.org/10.1182/blood-2022-159793
Autor:
Natasha Lopes Fischer, Mark A. Boyer, William P. Bradley, Lynn A. Spruce, Hossein Fazelinia, Sunny Shin
Intracellular bacteria such as the pathogen Coxiella burnetii inject effector proteins into the host cell that promote productive infection. One common strategy of pathogen effectors is to suppress host immune responses to enable pathogen replication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beeec710c12d70435969eff235e230c6
https://doi.org/10.1101/2022.04.20.488957
https://doi.org/10.1101/2022.04.20.488957
