Deep behavioural phenotyping of the Q175 Huntington disease mouse model: effects of age, sex, and weight

Autor: Ellen T. Koch, Judy Cheng, Daniel Ramandi, Marja D. Sepers, Alex Hsu, Tony Fong, Timothy H. Murphy, Eric Yttri, Lynn A. Raymond

Publikováno v: BMC Biology, Vol 22, Iss 1, Pp 1-19 (2024)

Abstract Background Huntington disease (HD) is a neurodegenerative disorder with complex motor and behavioural manifestations. The Q175 knock-in mouse model of HD has gained recent popularity as a genetically accurate model of the human disease. Howe

Externí odkaz: https://doaj.org/article/abbc69e7a5c44729926d173be44cabc4

Making America Competitive: Policies for a Global Future Marcia Lynn Whicker Raymond A. Moore

Autor: Mayo, Edward J.

Publikováno v: Presidential Studies Quarterly, 1991 Apr 01. 21(2), 419-421.

Externí odkaz: https://www.jstor.org/stable/27550753

Safety and efficacy of valbenazine for the treatment of chorea associated with Huntington's disease (KINECT-HD): a phase 3, randomised, double-blind, placebo-controlled trial

Autor: Erin Furr Stimming, Daniel O Claassen, Elise Kayson, Jody Goldstein, Raja Mehanna, Hui Zhang, Grace S Liang, Dietrich Haubenberger, Jamie Adams, Christopher Beck, Cheryl Chen, Martha Nance, Claudia Testa, Patricia Huffman, Amy Chesire, Frederick Marshall, Praveen Dayalu, Angela Stovall, Deborah Hall, Jacob Hawkins, Letty Ginsburg, Henry Moore, Tiago Mestre, Tanya Thompson, Natalie Connors, H. Diana Rosas, Allison Daley, Sandra K. Kostyk, Casey Mitchell, Amy Hellman, Sheryl Houston, Danielle Buchanan, Katherine McDonell, Stewart A. Factor, Elaine Sperin, Andrea Hurt, Joanne Wojcieszek, Mike Adurogbangba, Lynn A. Raymond, Jody Corey-Bloom, Chase Snell, Courtney Blair, Victor Sung, Sophia Antonioli, Jacqueline Fung, Simon Laganiere, Luis Sierra, William M. Mallonee, Greg Suter, Danny Bega, Zsa Zsa Brown, Lawrence Elmer, Nancy Vollmar, Debra del Castillo, Yi-Han Lin, Kelly Andrzejewski, Patricia Weigel, Trevor Hawkins, Kendra Kirby, Cimmaron Retzik-Stahr, Lauren Seeberger, Rohit Dhall, Anja Rassmann, McKenzie Luxmore, Burton Scott, James Boyd, Katherine Chan, Nikolaus McFarland, Kyle Rizer, Patricia Conlon, Valerie Suski, Federico Rodriguez-Porcel, Sandra Wilson, Christine Farrell, David Hunter, David Houghton, Sarah Seoane, Clare Gibbons, Philippe Rizek, Robin Kuprewicz, Steven Lo, Miroslav Cuturic, Vicki Segro, Kate Greenly, Fredy Revilla, Enrique Urrea-Mendoza, Kevin J. Black, Thomas Davis, Natividad Stover, Andrew Duker, Jay Van Gerpen, Peter Hedera, William Ondo, Karen Anderson, Stephen Bradley, Ken Cheung, Samuel Frank

Publikováno v: The Lancet Neurology. 22:494-504

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9521bbc7c5886201c53a98dc988016d
https://doi.org/10.1016/s1474-4422(23)00127-8

Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease

Autor: Mandi E. Schmidt, Caodu Buren, James P. Mackay, Daphne Cheung, Louisa Dal Cengio, Lynn A. Raymond, Michael R. Hayden

Publikováno v: BMC Biology, Vol 16, Iss 1, Pp 1-12 (2018)

Abstract Background Huntington disease (HD) is a fatal neurodegenerative disorder caused by a CAG expansion in the huntingtin (HTT) gene, leading to selective and progressive neuronal death predominantly in the striatum. Mutant HTT expression causes

Externí odkaz: https://doaj.org/article/a375911085d048ab94d74e1ba76b8a3c

Altered Regulation of Striatal Neuronal N-Methyl-D-Aspartate Receptor Trafficking by Palmitoylation in Huntington Disease Mouse Model

Autor: Rujun Kang, Liang Wang, Shaun S. Sanders, Kurt Zuo, Michael R. Hayden, Lynn A. Raymond

Publikováno v: Frontiers in Synaptic Neuroscience, Vol 11 (2019)

N-methyl-D-aspartate receptors (NMDARs) play a critical role in synaptic signaling, and alterations in the synaptic/extrasynaptic NMDAR balance affect neuronal survival. Studies have shown enhanced extrasynaptic GluN2B-type NMDAR (2B-NMDAR) activity

Externí odkaz: https://doaj.org/article/cbe10b457f9940f483f0fc2f41fbb3cb