Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Lynley, Marshall"'
Autor:
Nicola Fenwick, Rebekah Weston, Keith Wheatley, Jodie Hodgson, Lynley Marshall, Martin Elliott, Guy Makin, Antony Ng, Bernadette Brennan, Stephen Lowis, Jenny Adamski, John Paul Kilday, Rachel Cox, Mike Gattens, Andrew Moore, Toby Trahair, Milind Ronghe, Martin Campbell, Helen Campbell, Molly W. Williams, Maria Kirby, Natasha Van Eijkelenburg, Jennifer Keely, Ugo Scarpa, Victoria Stavrou, Livingstone Fultang, Sarah Booth, Paul Cheng, Carmela De Santo, Francis Mussai
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundThe survival for many children with relapsed/refractory cancers remains poor despite advances in therapies. Arginine metabolism plays a key role in the pathophysiology of a number of pediatric cancers. We report the first in child study of
Externí odkaz:
https://doaj.org/article/4902b15b11094343be86c12a848d2cb8
Autor:
Kelly C. Goldsmith, Julie R. Park, Kimberly Kayser, Jemily Malvar, Yueh-Yun Chi, Susan G. Groshen, Judith G. Villablanca, Kateryna Krytska, Lillian M. Lai, Patricia T. Acharya, Fariba Goodarzian, Bruce Pawel, Hiroyuki Shimada, Susan Ghazarian, Lisa States, Lynley Marshall, Louis Chesler, Meaghan Granger, Ami V. Desai, Rajen Mody, Daniel A. Morgenstern, Suzanne Shusterman, Margaret E. Macy, Navin Pinto, Gudrun Schleiermacher, Kieuhoa Vo, Holger C. Thurm, Joseph Chen, Marlon Liyanage, Gerson Peltz, Katherine K. Matthay, Esther R. Berko, John M. Maris, Araz Marachelian, Yael P. Mossé
Publikováno v:
Nature Medicine. 29:1092-1102
Neuroblastomas harbor ALK aberrations clinically resistant to crizotinib yet sensitive pre-clinically to the third-generation ALK inhibitor lorlatinib. We conducted a first-in-child study evaluating lorlatinib with and without chemotherapy in childre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05cb1069b5caae85576f8251b56aaa50
https://doi.org/10.1038/s41591-023-02297-5
https://doi.org/10.1038/s41591-023-02297-5
Autor:
Chris Jones, Paul Workman, David W. Ellison, Darren Hargrave, Andrew D.J. Pearson, Gilles Vassal, Rui M. Reis, Safa Al-Sarraj, João N. Stávale, Jorge S. Reis-Filho, Swee Y. Sharp, Raisa Vuononvirta, Marta Viana-Pereira, Marie Regairaz, Lara Perryman, Lynley Marshall, Suzanne E. Little, Nathalie Gaspar, Dorine A. Bax
Purpose: The epidermal growth factor receptor (EGFR) is amplified and overexpressed in adult glioblastoma, with response to targeted inhibition dependent on the underlying biology of the disease. EGFR has thus far been considered to play a less impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6f20bbf3a397a92e286ae0d352d4a8
https://doi.org/10.1158/1078-0432.c.6517390
https://doi.org/10.1158/1078-0432.c.6517390
Autor:
Chris Jones, Paul Workman, David W. Ellison, Darren Hargrave, Andrew D.J. Pearson, Gilles Vassal, Rui M. Reis, Safa Al-Sarraj, João N. Stávale, Jorge S. Reis-Filho, Swee Y. Sharp, Raisa Vuononvirta, Marta Viana-Pereira, Marie Regairaz, Lara Perryman, Lynley Marshall, Suzanne E. Little, Nathalie Gaspar, Dorine A. Bax
Supplementary Data from EGFRvIII Deletion Mutations in Pediatric High-Grade Glioma and Response to Targeted Therapy in Pediatric Glioma Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb9fa3e4c6dece4dde15dbc50c03193
https://doi.org/10.1158/1078-0432.22440010
https://doi.org/10.1158/1078-0432.22440010
Autor:
Tom Kurzawinski, Jonathan Hubbard, Tarek Abdel Aziz, Colin Butler, Mark Gaze, Caroline Brain, Lynley Marshall, null Shankar
Publikováno v:
British Journal of Surgery. 109
Background Patients with MEN2 without family history often present late with advanced MTC. Surgery is not always curative but RET tyrosine kinase pathway is a potential target for molecular treatment for progressive MTC. Methods Retrospective review
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96ef58ce5732eed2b2fee708149387ca
https://doi.org/10.1093/bjs/znac057.002
https://doi.org/10.1093/bjs/znac057.002
Autor:
Andrew Dj, Pearson, Claudia, Rossig, Crystal, Mackall, Nirali N, Shah, Andre, Baruchel, Gregory, Reaman, Rosanna, Ricafort, Delphine, Heenen, Abraham, Bassan, Michael, Berntgen, Nick, Bird, Eric, Bleickardt, Najat, Bouchkouj, Peter, Bross, Carrie, Brownstein, Sarah Beaussant, Cohen, Teresa, de Rojas, Lori, Ehrlich, Elizabeth, Fox, Stephen, Gottschalk, Linda, Hanssens, Douglas S, Hawkins, Ivan D, Horak, Danielle H, Taylor, Courtney, Johnson, Dominik, Karres, Franca, Ligas, Donna, Ludwinski, Maksim, Mamonkin, Lynley, Marshall, Behzad K, Masouleh, Yousif, Matloub, Shannon, Maude, Joe, McDonough, Veronique, Minard-Colin, Koen, Norga, Karsten, Nysom, Alberto, Pappo, Laura, Pearce, Rob, Pieters, Martin, Pule, Alfonso, Quintás-Cardama, Nick, Richardson, Martina, Schüßler-Lenz, Nicole, Scobie, Martina A, Sersch, Malcolm A, Smith, Jaroslav, Sterba, Sarah K, Tasian, Brenda, Weigel, Susan L, Weiner, Christian Michel, Zwaan, Giovanni, Lesa, Gilles, Vassal
Publikováno v:
European journal of cancer
European journal of cancer, 160:112-133
European journal of cancer, 160:112-133
The seventh multi-stakeholder Paediatric Strategy Forum focused on chimeric antigen receptor (CAR) T-cells for children and adolescents with cancer. The development of CAR T-cells for patients with haematological malignancies, especially B-cell precu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7e4b2ff665e9b497893f3198ef4554c2
https://repository.uantwerpen.be/docstore/d:irua:12922
https://repository.uantwerpen.be/docstore/d:irua:12922
Autor:
Andrew Dj, Pearson, Kimberly, Stegmaier, Franck, Bourdeaut, Gregory, Reaman, Delphine, Heenen, Michael L, Meyers, Scott A, Armstrong, Patrick, Brown, Daniel, De Carvalho, Nada, Jabado, Lynley, Marshall, Miguel, Rivera, Malcolm, Smith, Peter C, Adamson, Amy, Barone, Christian, Baumann, Samuel, Blackman, Vickie, Buenger, Martha, Donoghue, Aundrietta D, Duncan, Elizabeth, Fox, Brian, Gadbaw, Maureen, Hattersley, Peter, Ho, Ira, Jacobs, Michael J, Kelly, Mark, Kieran, Giovanni, Lesa, Franca, Ligas, Donna, Ludwinski, Joe, McDonough, Zariana, Nikolova, Koen, Norga, Adrian, Senderowicz, Tilmann, Taube, Susan, Weiner, Dominik, Karres, Gilles, Vassal
Publikováno v:
European journal of cancer
The fifth multistakeholder Paediatric Strategy Forum focussed on epigenetic modifier therapies for children and adolescents with cancer. As most mutations in paediatric malignancies influence chromatin-associated proteins or transcription and paediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::eee50db77fe7c0e7c72791d7c8fbba20
https://repository.uantwerpen.be/docstore/d:irua:3630
https://repository.uantwerpen.be/docstore/d:irua:3630
Autor:
Dorine A Bax, Suzanne E Little, Nathalie Gaspar, Lara Perryman, Lynley Marshall, Marta Viana-Pereira, Tania A Jones, Richard D Williams, Anita Grigoriadis, Gilles Vassal, Paul Workman, Denise Sheer, Rui M Reis, Andrew D J Pearson, Darren Hargrave, Chris Jones
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5209 (2009)
Although paediatric high grade gliomas resemble their adult counterparts in many ways, there appear to be distinct clinical and biological differences. One important factor hampering the development of new targeted therapies is the relative lack of c
Externí odkaz:
https://doaj.org/article/4d6745336d244c4e8dc3df8b58736e76
Autor:
Louis Chesler, Jane Chalker, Brian A Walker, Debbie Hicks, Andrew S. Moore, Khin Thway, Paula Proszek, Thomas S. Jacques, Janet Shipley, Chris Jones, Caedyn Stinson, Elisa Izquierdo, Sally L. George, Lucas Moreno, Lynley Marshall, Janet C. Lindsey, Andrew D.J. Pearson, David Gonzalez de Castro, Simon O'Connor, Mike Hubank, Rebecca M Hill, Lina Yuan, Susanne A. Gatz, Steven C. Clifford
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Repisalud
Instituto de Salud Carlos III (ISCIII)
Oncotarget
Consejería de Sanidad de la Comunidad de Madrid
Repisalud
Instituto de Salud Carlos III (ISCIII)
Oncotarget
The implementation of personalised medicine in childhood cancers has been limited by a lack of clinically validated multi-target sequencing approaches specific for paediatric solid tumours. In order to support innovative clinical trials in high-risk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732dd5b43b778e5a7b48fd98c6edd8c0
https://hdl.handle.net/20.500.12105/7410
https://hdl.handle.net/20.500.12105/7410
Autor:
Alan Mackay, Diana Carvalho, Valeria Molinari, Helen Pemberton, Sara Temelso, Anna Burford, Matthew Clarke, Mariama Fofana, Jessica Boult, Elisa Izquierdo, Katy Taylor, Lynn Bjerke, Janat Fazal Salom, Ketty Kessler, Rebecca Rogers, Lynley Marshall, Fernando Carceller, Jane Pears, Andrew Moore, Evelina Miele, Andrea Carai, Angela Mastronuzzi, Simon Robinson, Chris Lord, Nagore Olaciregui, Jaume Mora, Angel Montero Carcaboso, Darren Hargrave, Maria Vinci, Chris Jones
Publikováno v:
Neuro-Oncology. 20:vi210-vi210
Paediatric high grade glioma and diffuse midline glioma (including DIPG) are comprised of multiple biological and clinical subgroups, the majority of which urgently require novel therapies. Patient-derived in vitro primary cell cultures represent pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f876745b1ff6c10a67dfb5dd7b0256db
https://doi.org/10.1093/neuonc/noy148.871
https://doi.org/10.1093/neuonc/noy148.871