Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Lynette Steele"'
Autor:
Lynette Steele, Aarren J. Mannion, Gary Shaw, Kenneth A. Maclennan, Graham P. Cook, Christopher E. Rudd, Alison Taylor
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102555- (2021)
Summary: Glycogen synthase kinase-3 (GSK-3) is a positive regulator of PD-1 expression in CD8+ T cells and GSK-3 inhibition enhances T cell function and is effective in the control of tumor growth. GSK-3 has two co-expressed isoforms, GSK-3α and GSK
Externí odkaz:
https://doaj.org/article/3f9855539d254976a5185ff195874f3e
Autor:
Helen Carrasco Hope, Rebecca J. Brownlie, Christopher M. Fife, Lynette Steele, Mihaela Lorger, Robert J. Salmond
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
T cell receptor (TCR) triggering by antigen results in metabolic reprogramming that, in turn, facilitates the exit of T cells from quiescence. The increased nutrient requirements of activated lymphocytes are met, in part, by upregulation of cell surf
Externí odkaz:
https://doaj.org/article/f09dbfc3ff2c45ebbd590954c6ced5e4
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64051 (2013)
Pediatric high grade glioma is refractory to conventional multimodal treatment, highlighting a need to develop novel efficacious therapies. We investigated tumor metabolism as a potential therapeutic target in a panel of diverse pediatric glioma cell
Externí odkaz:
https://doaj.org/article/35cb4bf5aa484e7e9458b0e97517e932
Autor:
Henry King, Alastair Droop, Ewan E. Morrison, Ruth Morton, Susan C Short, Julie Higgins, Gary Shaw, Peter Laslo, B. da Silva, Euan S. Polson, Lynette Steele, Daniel Tams, Heather L. Martin, Matthew Adams, Heiko Wurdak, Darren C. Tomlinson, Sean E. Lawler, Marjorie Boissinot, Josie Hayes, Jacquelyn Bond, Thomas Ward
Publikováno v:
Oncogene
MicroRNAs play an important role in the regulation of mRNA translation and have therapeutic potential in cancer and other diseases. To profile the landscape of microRNAs with significant cytotoxicity in the context of glioblastoma (GBM), we performed
Autor:
Anke Brüning-Richardson, Gary C. Shaw, Daniel Tams, Tim Brend, Hitesh Sanganee, Simon T. Barry, Gregory Hamm, Richard J. A. Goodwin, John G. Swales, Henry King, Lynette Steele, Ruth Morton, Anastasia Widyadari, Thomas A. Ward, Filomena Esteves, Marjorie Boissinot, Georgia Mavria, Alastair Droop, Sean E. Lawler, Susan C. Short
Publikováno v:
Cancers. 14:3789
The authors wish to make the following corrections to this paper [1] [...]
Autor:
Christopher M Fife, Helen Carrasco Hope, Robert J Salmond, Lynette Steele, Rebecca J. Brownlie, Mihaela Lorger
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
JCI Insight
JCI Insight
T cell receptor (TCR) triggering by antigen results in metabolic reprogramming that, in turn, facilitates the exit of T cells from quiescence. The increased nutrient requirements of activated lymphocytes are met, in part, by upregulation of cell surf
T cell receptor triggering by antigen results in metabolic reprogramming that, in turn, facilitates T cells’ exit from quiescence. The increased nutrient requirements of activated lymphocytes are met in part by upregulation of cell surface transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f02e3b5ae0090027378445d9f3b658
Autor:
Jill Thompson, Timothy Kottke, Richard G. Vile, Elizabeth Ilett, Rob C. Hoeben, Lynette Steele, Diana J. M. van den Wollenberg, Matthew C. Coffey, Robert A. Berkeley, Alan Melcher, Aat A. Mulder
Publikováno v:
Cancer Immunology Research, 6(10), 1161-1173
Immunotherapy is showing promise for otherwise incurable cancers. Oncolytic viruses (OVs), developed as direct cytotoxic agents, mediate their antitumor effects via activation of the immune system. However, OVs also stimulate antiviral immune respons
Autor:
Anke Brüning-Richardson, Gary Shaw, Daniel Tams, Tim Brend, Hitesh Sanganee, Simon Barry, Gregory Hamm, Richard Goodwin, John Swales, Henry King, Lynette Steele, Ruth Morton, Anastasia Widyadari, Thomas Ward, Filomena Esteves, Marjorie Boissinot, Georgia Mavria, Alastair Droop, Sean Lawler, Susan Short
Publikováno v:
Cancers; Volume 13; Issue 23; Pages: 5939
Cancers, Vol 13, Iss 5939, p 5939 (2021)
Cancers
Cancers, Vol 13, Iss 5939, p 5939 (2021)
Cancers
Simple Summary High-grade gliomas remain difficult-to-treat cancers. Novel treatment options include targeting glycogen synthase kinase 3 (GSK-3) to induce cell death but the mode of drug activity remains unknown and combination with conventional tre
Autor:
Aarren J. Mannion, Alison Taylor, Gary Shaw, Christopher E. Rudd, Kenneth A. MacLennan, Graham P. Cook, Lynette Steele
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102555-(2021)
iScience
iScience
Summary Glycogen synthase kinase-3 (GSK-3) is a positive regulator of PD-1 expression in CD8+ T cells and GSK-3 inhibition enhances T cell function and is effective in the control of tumor growth. GSK-3 has two co-expressed isoforms, GSK-3α and GSK-