Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lynette S, Chea"'
Autor:
Hweixian L Penny, Yanchen Zhou, Mark A Kroenke, Bianca Bautista, Kelly Hainline, Lynette S Chea, Jane Parnes, Daniel T Mytych
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 4 (2022)
Externí odkaz:
https://doaj.org/article/d4195547369b45f4a63d1c15bf26da04
Autor:
Yanchen Zhou, Hweixian L Penny, Mark A Kroenke, Bianca Bautista, Kelly Hainline, Lynette S Chea, Jane Parnes, Daniel T Mytych
Publikováno v:
Journal for immunotherapy of cancer. 10(4)
With increasing numbers of bispecific antibodies (BsAbs) and multispecific products entering the clinic, recent data highlight immunogenicity as an emerging challenge in the development of such novel biologics. This review focuses on the immunogenici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de9fe04ab4045cd99e548e90a3b0c193
https://pubmed.ncbi.nlm.nih.gov/35444060
https://pubmed.ncbi.nlm.nih.gov/35444060
Autor:
Lynette S. Chea, Rama Rao Amara
Publikováno v:
Expert Review of Vaccines. 16:973-985
Despite 30 years of research on HIV, a vaccine to prevent infection and limit disease progression remains elusive. The RV144 trial showed moderate, but significant protection in humans and highlighted the contribution of antibody responses directed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca363fcc18b1225ecac4cb09751eb20
https://doi.org/10.1080/14760584.2017.1371594
https://doi.org/10.1080/14760584.2017.1371594
Autor:
Traci Legere, Richard Green, James R. Bowen, Courtney Wilkins, Lynette S. Chea, Sunil Kannanganat, Tianwei Yu, Vijayakumar Velu, Jean Chang, Michelle A. Lifton, Venkateswarlu Chamcha, Sampa Santra, Pradeep B. J. Reddy, Cynthia A. Derdeyn, Pamela A. Kozlowski, Francois Villinger, Guido Silvestri, Eric Hunter, Rama Rao Amara, Sailaja Gangadhara, Lakshmi Chennareddi, Mehul S. Suthar, G. Lynn Law, Michael Gale
Publikováno v:
Sci Transl Med
Activated CD4 T cells are a major target of HIV infection. Results from the STEP HIV vaccine trial highlighted a potential role for total activated CD4 T cells in promoting HIV acquisition. However, the influence of vaccine insert-specific CD4 T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::138140c4eea73b27c368fc0bd603aef7
https://europepmc.org/articles/PMC7227795/
https://europepmc.org/articles/PMC7227795/
Publikováno v:
Journal of Virology. 93
Modified vaccinia virus Ankara (MVA), an attenuated poxvirus, has been developed as a potential vaccine vector for use against cancer and multiple infectious diseases, including human immunodeficiency virus (HIV). MVA is highly immunogenic and elicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f2cf9484561505e108f507128519221
https://doi.org/10.1128/jvi.01648-18
https://doi.org/10.1128/jvi.01648-18
Autor:
Linda S. Wyatt, Lynette S. Chea, Rama Rao Amara, Lakshmi Chennareddi, Thomas H. Vanderford, Benton Lawson, Bernard Moss, Pamela A. Kozlowski, Harriet L. Robinson, Pradeep B. J. Reddy, Venkatesarlu Chamcha, Sunil Kannanganat, Sailaja Gangadhara, Tiffany M. Styles, Celia C. LaBranche, David C. Montefiori
Publikováno v:
The Journal of Immunology. 197:3586-3596
We tested, in rhesus macaques, the effects of a 500-fold range of an admixed recombinant modified vaccinia Ankara (MVA) expressing rhesus GM-CSF (MVA/GM-CSF) on the immunogenicity and protection elicited by an MVA/SIV macaque 239 vaccine. High doses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8fb9fcb71bdfd3fba702c26cb09b863
https://doi.org/10.4049/jimmunol.1600629
https://doi.org/10.4049/jimmunol.1600629
Autor:
Steven E. Bosinger, Smita S. Iyer, Rafi Ahmed, Jacob D. Estes, Gordon J. Freeman, Rama Rao Amara, Claire Deleage, Gregory K. Tharp, Lynette S. Chea, Geetha H. Mylvaganam, Sakeenah L. Hicks, Vijayakumar Velu
Publikováno v:
JCI Insight. 3
Therapeutic strategies that augment antiviral immunity and reduce the viral reservoir are critical to achieving durable remission of HIV. The coinhibitory receptor programmed death-1 (PD-1) regulates CD8+ T cell dysfunction during chronic HIV and SIV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4445281c23d335127a357206d16cb0
https://doi.org/10.1172/jci.insight.122940
https://doi.org/10.1172/jci.insight.122940
Publikováno v:
Journal of virology. 93(5)
Modified vaccinia virus Ankara (MVA), an attenuated poxvirus, has been developed as a potential vaccine vector for use against cancer and multiple infectious diseases, including human immunodeficiency virus (HIV). MVA is highly immunogenic and elicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cfc5840525aa650a414cc3bfa17f1165
https://pubmed.ncbi.nlm.nih.gov/30541829
https://pubmed.ncbi.nlm.nih.gov/30541829
Autor:
Lance R. Pohl, Mohammed Bourdi, Warren J. Leonard, Lynette S. Chea, Julia D. Berkson, Midhun C. Korrapati, Kenrick Semple, Albert P. Li, Rosanne Spolski, William R. Proctor, Jeffrey C. Morrison, Qian Yang, Aaron M. Fullerton, Mala Chakraborty, Pauline M. Ryan, Yrina Rochman, Erin E. West
Publikováno v:
Hepatology (Baltimore, Md.). 60(5)
Liver eosinophilia has been associated with incidences of drug-induced liver injury (DILI) for more than 50 years, although its role in this disease has remained largely unknown. In this regard, it was recently shown that eosinophils played a pathoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ca9c4444b273d08706d61d49eab7ca
https://pubmed.ncbi.nlm.nih.gov/24913773
https://pubmed.ncbi.nlm.nih.gov/24913773
Autor:
Mala Chakraborty, Lynette S. Chea, Kenrick Semple, Julia D. Berkson, William R. Proctor, Lance R. Pohl, Mohammed Bourdi, Jeffrey C. Morrison
Drug-induced liver injury (DILI) is a major health issue, as it remains difficult to predict which new drugs will cause injury and who will be susceptible to this disease. This is due in part to the lack of animal models and knowledge of susceptibili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edfc1b16c7a8603c511b062ac956e080
https://europepmc.org/articles/PMC3610837/
https://europepmc.org/articles/PMC3610837/