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pro vyhledávání: '"Lynette Mullens"'
Up-regulation of lipocortin-1 and its mRNA in reactive astrocytes in kainate-lesioned rat cerebellum
Autor:
Karen A. Young, Derek R. Marriott, Graham P. Wilkin, Lynette Mullens, Lesley A. Tannahill, Stafford L. Lightman
Publikováno v:
Journal of Neuroimmunology. 50:25-33
We have used a combined molecular and immunocytochemical approach to examine the expression of lipocortin-1 (LC-1) in kainate-lesioned rat cerebellum. Using immunocytochemistry, Western and Northern blotting, we have shown upregulation of LC-1 mRNA a
Autor:
Jacques Motte, Penelope Manasco, Edwin Trevathan, Jan F.V. Arvidsson, Manuel Nieto Barrera, E. Lynette Mullens
Publikováno v:
The New England journal of medicine. 339(12)
Background The Lennox–Gastaut syndrome, a severe form of epilepsy that usually begins in early childhood, is difficult to treat. Dose-related drug toxicity is common. Methods We conducted a double-blind, placebo-controlled trial of the antiepilepti
Publikováno v:
Drug safety. 18(4)
To date approximately 4000 adults >12 years of age have been treated with lamotrigine in Glaxo Wellcome sponsored clinical trials. Review of the data from these trials shows lamotrigine to be effective and well tolerated in both add-on and monotherap