Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Lynette C Foo"'
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110668 (2014)
Astrocytes constitute a major cell population in the brain with a myriad of essential functions, yet we know remarkably little about the signaling pathways and mechanisms that direct astrocyte maturation. To explore the signals regulating astrocyte d
Externí odkaz:
https://doaj.org/article/83831324e84c492e8ede14f5634c888d
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Multiple sclerosis (MS) is the most common demyelinating autoimmune disease of the central nervous system (CNS). Immune-mediated myelin and axonal damage that is accompanied by chronic axonal loss causing destruction of the myelin sheaths ar
Externí odkaz:
https://doaj.org/article/d7f373e8500344009c09b8a6c7ef7d6a
Autor:
Will Macnair, Daniela Calini, Eneritz Agirre, Julien Bryois, Sarah Jäkel, Petra Kukanja, Nadine Stokar-Regenscheit, Virginie Ott, Lynette C. Foo, Ludovic Collin, Sven Schippling, Eduard Urich, Erik Nutma, Manuel Marzin, Sandra Amor, Roberta Magliozzi, Elyas Heidari, Mark D. Robinson, Charles ffrench-Constant, Gonçalo Castelo-Branco, Anna Williams, Dheeraj Malhotra
The lack of understanding as to the cellular and molecular basis of clinical and genetic heterogeneity in progressive multiple sclerosis (MS) has hindered the search for new effective therapies and biomarkers. Here, to address this gap, we analysed 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82ac11ba9c2fd8f4a2ebc946257f7694
https://doi.org/10.1101/2022.04.06.487263
https://doi.org/10.1101/2022.04.06.487263
Autor:
Julien Muffat, Carole Escartin, Tirzah Kreisel, Emilie Hangen, Nicole Déglon, Nathalie Linck, Sara Regio, Sybille Rion, Inbal Goshen, Lynette C. Foo, Jaime Grutzendler, Hélène Hirbec
Publikováno v:
Glia
Glia, 2020, ⟨10.1002/glia.23780⟩
Glia, Wiley, 2020, ⟨10.1002/glia.23780⟩
Glia, 2020, ⟨10.1002/glia.23780⟩
Glia, Wiley, 2020, ⟨10.1002/glia.23780⟩
International audience; Development, physiological functions, and pathologies of the brain depend on tight interactions between neurons and different types of glial cells, such as astrocytes, microglia, oligodendrocytes, and oligodendrocyte precursor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acc76ab2ee3e473c80a8114c2b3d274
https://doi.org/10.1002/glia.23780
https://doi.org/10.1002/glia.23780
Publikováno v:
The EMBO Journal
The study of adult neural cell production has concentrated on neurogenesis. The mechanisms controlling adult gliogenesis are still poorly understood. Here, we provide evidence for a homeostatic process that maintains the population of glial cells in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a797035a61b137c498f1649bd24ffe1
http://europepmc.org/articles/PMC5412881
http://europepmc.org/articles/PMC5412881
Autor:
Lynette C. Foo, Deepak Choudhury, Fang Yu, Sum Huan Ng, Walter Hunziker, Nivasini D, O Selva Kumar
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 117(4)
Disruption of the blood-brain barrier (BBB) leads to various neurovascular diseases. Development of therapeutics required to cross the BBB is difficult due to a lack of relevant in vitro models. We have developed a three-dimensional (3D) microfluidic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8892e9b729e546b62d198351b607b7
https://pubmed.ncbi.nlm.nih.gov/31885078
https://pubmed.ncbi.nlm.nih.gov/31885078
Publikováno v:
Drug discovery today. 23(4)
Microfluidic platforms have recently become popular as in vitro models because of their superiority in recapitulating microenvironments compared with conventional in vitro models. By providing various biochemical and biomechanical cues, healthy and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6529f59ff5e7fd90d85a0542c958b6e
https://pubmed.ncbi.nlm.nih.gov/29357288
https://pubmed.ncbi.nlm.nih.gov/29357288
Autor:
Lynette C. Foo
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Neuronal and glial progenitor cells exist in the adult Drosophila brain. The primarily glial progenitor cells rely on a microRNA, mir-31a, to inhibit the expression of a predicted E3 ubiquitin ligase, CG16947. Erroneous inheritance of CG16947 by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5c72d9f53aa80ae37e173720171f26
https://pubmed.ncbi.nlm.nih.gov/28754981
https://pubmed.ncbi.nlm.nih.gov/28754981
Autor:
Lynette C. Foo, Joseph D. Dougherty
Publikováno v:
Glia. 61:1533-1541
The metabolic enzyme for folate, Aldh1L1, has been shown to be expressed robustly in astrocytes of the brain. It is now well accepted that astrocytes in certain regions of the adult brain also serve as neural stem cells. Here, we examined whether Ald
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5388312c3654ec3156dec84a2d3ba783
https://doi.org/10.1002/glia.22539
https://doi.org/10.1002/glia.22539
Autor:
David H. Gutmann, Ben A. Barres, Joseph D. Dougherty, Lynette C. Foo, David H. Rowitch, Anna V. Molofsky, Nathaniel Heintz, Aparna Kaul, An-Chi Tien, Martin McMahon, Hui-Hsin Tsai
Publikováno v:
Development. 139:2477-2487
Expansion of astrocyte populations in the central nervous system is characteristic of evolutionarily more complex organisms. However, regulation of mammalian astrocyte precursor proliferation during development remains poorly understood. Here, we use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f61196e2631731fe93097cd4d90a0f
https://doi.org/10.1242/dev.077214
https://doi.org/10.1242/dev.077214