Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lynette A. Smyth"'
Autor:
Per-Ola Norrby, Lynette A. Smyth, Ola Engkvist, Edward C. Sherer, Nidhal Selmi, Willi Amberg, Yu-hong Lam, Thomas Erhard, Zhengwei Peng
Publikováno v:
Drug Discovery Today. 23:1203-1218
Over the past few decades, various computational methods have become increasingly important for discovering and developing novel drugs. Computational prediction of chemical reactions is a key part of an efficient drug discovery process. In this revie
Autor:
Eric M. Phillips, Rodger F. Henry, Lynette A. Smyth, Shashank Shekhar, José G. Napolitano, Vincent S. Chan
Publikováno v:
ChemInform. 47
A novel method for Pd-catalyzed triflination of aryl and heteroaryl triflates using NaSO2CF3 as the nucleophile is described. The combination of Pd2(dba)3 and RockPhos formed the most effective catalyst. A broad range of functional groups and heteroa
Autor:
Shashank Shekhar, Vincent S. Chan, Rodger F. Henry, José G. Napolitano, Eric M. Phillips, Lynette A. Smyth
Publikováno v:
The Journal of organic chemistry. 81(3)
A novel method for Pd-catalyzed triflination of aryl and heteroaryl triflates using NaSO2CF3 as the nucleophile is described. The combination of Pd2(dba)3 and RockPhos formed the most effective catalyst. A broad range of functional groups and heteroa
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:3569-3578
A lead-like kinase inhibitor screening library containing new 3-aminopyrazolopyridinones and closely related compounds was designed that contained hydrogen-bond donor-acceptor motifs and substitution vectors inspired by the natural product kinase inh
Autor:
Yann Jamin, Simon P. Robinson, Martin O. Leach, Geoffrey S. Payne, Thomas R. Eykyn, Evon Poon, Lynette A. Smyth, Caroline J. Springer
Publikováno v:
NMR in Biomedicine. 24:343-350
The pseudomonad protein, carboxypeptidase G2 (CPG2), is a prodrug-activating enzyme utilized in the targeted chemotherapy strategies of antibody- and gene-directed enzyme prodrug therapy (ADEPT and GDEPT). We have developed a noninvasive imaging appr
Publikováno v:
Tetrahedron. 66:2843-2854
3-Amino-1H-pyrazolo[4,3-c]pyridin-4(5H)-ones represent a potentially attractive heteroaromatic scaffold for drug-discovery chemistry. In particular, the arrangement of hydrogen bond donor and acceptor groups in the bicyclic core can fulfil the requir
Autor:
Lynette A. Smyth, Steven Reynolds, Simon P. Robinson, Cristina Gabellieri, Martin O. Leach, Caroline J. Springer, Yann Jamin, Thomas R. Eykyn, Geoffrey S. Payne
Publikováno v:
Magnetic Resonance in Medicine. 62:1300-1304
Carboxypeptidase G2 (CPG2) is a bacterial enzyme that is currently employed in a range of targeted cancer chemotherapy strategies such as gene-directed enzyme prodrug therapy (GDEPT). Employing dynamic nuclear polarization (DNP) and natural abundance
Autor:
Ian Collins, Lynette A. Smyth
Publikováno v:
Journal of Chemical Biology. 2:131-151
Protein kinase inhibitors are a well-established class of clinically useful drugs, particularly for the treatment of cancer. Achieving inhibitor selectivity for particular protein kinases often remains a significant challenge in the development of ne
Autor:
Roger John Griffin, Martin E.M. Noble, James M. McDonnell, Anna Watson, Jane A. Endicott, Stuart J. Kemp, Bernard T. Golding, Lynette A. Smyth, Christiane Riedinger, Eric Valeur, Ian R. Hardcastle
Publikováno v:
Journal of the American Chemical Society. 130:16038-16044
In this study we present a method for defining the binding modes of a set of structurally related isoindolinone inhibitors of the MDM2-p53 interaction. This approach derives the location and orientation of isoindolinone binding, based on an analysis
Publikováno v:
Tetrahedron. 63:9627-9634
The reaction of 2-(5-amino-4-carbamoyl-1-methyl-1H-pyrazol-3-yl)acetic acid and triethylorthoformate did not give the expected dihydropyrazolo[4,3-c]pyridin-4-one product as described in literature, but formed an alternative cyclic imide product, ful