Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lyne Levesque"'
Autor:
D. M. Zhang, Lyne Levesque, P. VanderVere, Gang Yu, Paul E. Fraser, Masaki Nishimura, Nicholas J. Murgolo, Catherine D. Strader, D. M. Xu, Ekaterina Rogaeva, Luquan Wang, Monika Duthie, Yan Liang, Haung Yu, Marvin L. Bayne, P. St. George-Hyslop, M. Ikeda, G. Levesque, Johanna M. Rommens
Publikováno v:
Journal of Neurochemistry. 72:999-1008
Missense substitutions in the presenilin 1 (PS1) and presenilin 2 (PS2) proteins are associated with early-onset familial Alzheimer's disease. We have used yeast-two-hybrid and coimmunoprecipitation methods to show that the large cytoplasmic loop dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5822eef23a7967c9d458f2bade4c312f
https://doi.org/10.1046/j.1471-4159.1999.0720999.x
https://doi.org/10.1046/j.1471-4159.1999.0720999.x
Autor:
Benjamin H. Kao, Melanie Picciano, Jochen Walter, Paul M. Mathews, David Nochlin, Athena Andreadis, Anne M. Cataldo, Xi Qin, Ying Jiang, Christian Haass, John L. Yang, Ralph A. Nixon, Carol F. Lippa, Lyne Levesque, Thomas D. Bird, Paul E. Fraser, Christine M. Hulette, Anna G. Rudnicki
Publikováno v:
Molecular Medicine. 6:878-891
Mutations in the presenilin proteins cause early-onset, familial Alzheimer’s disease (FAD). We characterized the cellular localization and endoproteolysis of presenilin 2 (PS2) and presenilin 1 (PS1) in brains from 25 individuals with presenilin-mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fac80162b09368a8ab710930f02a4555
https://doi.org/10.1007/bf03401825
https://doi.org/10.1007/bf03401825
Autor:
David Westaway, D. M. Xu, T. Kawakai, Agnes Supala, D. M. Zhang, Christopher Janus, Fusheng Chen, James R. Woodgett, Masaki Nishimura, Lars Lannfelt, Paul Milman, P. St. George-Hyslop, Ekaterina Rogaeva, Howard T.J. Mount, G. Levesque, Gang Yu, Paul E. Fraser, Euijung Jo, Richard Rozmahel, Erin Holmes, L. Ruel, Kari M. Mattila, Q. Bi, Monika Duthie, Lyne Levesque, Yan Liang
Publikováno v:
Nature Medicine. 5:164-169
The presenilin proteins are components of high-molecular-weight protein complexes in the endoplasmic reticulum and Golgi apparatus that also contain beta-catenin. We report here that presenilin mutations associated with familial Alzheimer disease (bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1933b34c760cdf17006bafe35d485484
https://doi.org/10.1038/5526
https://doi.org/10.1038/5526
Autor:
Toshiki Uchihara, Lyne Levesque, Peter St George-Hyslop, J. F. Foncin, Charles Duyckaerts, Paul E. Fraser, H. K. El Hachimi, Jean-Jacques Hauw
Publikováno v:
Acta Neuropathologica. 92:325-330
The immunolocalization of presenilin in human brain was studied using two antibodies raised against different portions of presenilin 1 (S182) protein. A granular staining was found in the cytoplasm of neurons in cortical layers III and V. One of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bac8a2bed01b32326dca1b8e9c27064
https://doi.org/10.1007/s004010050526
https://doi.org/10.1007/s004010050526
Autor:
Paul E. Fraser, G. Levesque, Lyne Levesque, David Westaway, P. St. George-Hyslop, Johanna M. Rommens
Publikováno v:
Cold Spring Harbor Symposia on Quantitative Biology. 61:559-564
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7caadbf32967ce34c540acfe5e4ab89d
https://doi.org/10.1101/sqb.1996.061.01.056
https://doi.org/10.1101/sqb.1996.061.01.056
Publikováno v:
Clinical Biochemistry. 26:339-349
One of the principal identifying features of Alzheimer's disease (AD) is the extracellular deposition of fibrous protein aggregates in the form of amyloid plaques. The major component of these deposits is the amyloid beta (A beta) protein that is a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0aab740fc823b06c8d172ad62b8db4
https://doi.org/10.1016/0009-9120(93)90110-r
https://doi.org/10.1016/0009-9120(93)90110-r
Autor:
Christopher Janus, Peter St George-Hyslop, Dun-Sheng Yang, Dong Mel Zhang, Marsha Smith, Yan Liang, Fusheng Chen, Christine Sato, Lindsay A. Farrer, Paul E. Fraser, Agnes Supala, You-Qiang Song, Toshitaka Kawarai, Haung Yu, Paul Milman, Lyne Levesque, Amalia C. Bruni, Shigeki Arawaka, Masaki Nishimura, Ekaterina Rogaeva, Evgeny I. Rogaev, Yanni Zhang, Ruedl Aebersold, Gang Yu, Lili Zhang, Anurag Tandon, Diane Levitan, Dong Hong Xu, Sandro Sorbl, Erin Holmes
Publikováno v:
Nature. 407(6800)
Nicastrin, a transmembrane glycoprotein, forms high molecular weight complexes with presenilin 1 and presenilin 2. Suppression of nicastrin expression in Caenorhabditis elegans embryos induces a subset of notch/glp-1 phenotypes similar to those induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220f02545ae345209ce92b595df50073
https://pubmed.ncbi.nlm.nih.gov/10993060
https://pubmed.ncbi.nlm.nih.gov/10993060
Publikováno v:
Brain research. 877(2)
Aluminum is present in many manufactured foods and medicines and is added to drinking water for purification purposes. It has been proposed that aluminum is a contributing factors to several neurodegenerative disorders such as Alzheimer's disease. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add01620c3396025413898e8a14b37d3
https://pubmed.ncbi.nlm.nih.gov/10986332
https://pubmed.ncbi.nlm.nih.gov/10986332
Publikováno v:
Journal of chromatography. B, Biomedical sciences and applications. 744(1)
A mixed-mode high-performance liquid chromatography (HPLC) method that resolves the six known non-allelic variants of chicken erythrocyte histone H1 is described. Common, but previously unknown, allelic variants of H1 that comigrate in polyacrylamide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf075604e741e93130730c382b0ffada
https://pubmed.ncbi.nlm.nih.gov/10985564
https://pubmed.ncbi.nlm.nih.gov/10985564
Autor:
D. M. Zhang, G. Levesque, David Westaway, Gang Yu, Anurag Tandon, Ekaterina Rogaeva, Peter St George-Hyslop, Toshitaka Kawarai, Lyne Levesque, Masaki Nishimura, Paul E. Fraser, Fusheng Chen, Howard T.J. Mount, Richard Rozmahel, S.E. Gandy, Dun-Sheng Yang, Suzana Petanceska, Austin J. Yang, Jorge Ghiso, Julia Mills, You-Qiang Song
Publikováno v:
The Journal of biological chemistry. 275(47)
Absence of functional presenilin 1 (PS1) protein leads to loss of gamma-secretase cleavage of the amyloid precursor protein (betaAPP), resulting in a dramatic reduction in amyloid beta peptide (Abeta) production and accumulation of alpha- or beta-sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23014346b5440eb04166ce3555ad7258
https://pubmed.ncbi.nlm.nih.gov/10962005
https://pubmed.ncbi.nlm.nih.gov/10962005