Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Lyne Khair"'
Autor:
Chiaki Noguchi, Tanu Singh, Melissa A. Ziegler, Jasmine D. Peake, Lyne Khair, Ana Aza, Toru M. Nakamura, Eishi Noguchi
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-17 (2019)
Abstract Background Histone acetylation plays an important role in DNA replication and repair because replicating chromatin is subject to dynamic changes in its structures. However, its precise mechanism remains elusive. In this report, we describe r
Externí odkaz:
https://doaj.org/article/723cf91027324fdfba49a3beee76c166
Autor:
Jinglian Yan, Guodong Tie, Shouying Wang, Amanda Tutto, Natale DeMarco, Lyne Khair, Thomas G. Fazzio, Louis M. Messina
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Type 2 diabetes is associated with impaired wound healing, which can lead to limb loss. Here, the authors show that in Type 2 diabetic mouse models, Dnmt1 is upregulated in hematopoietic stem cells, leading to impaired differentiation towards macroph
Externí odkaz:
https://doaj.org/article/4a2e03c93405462e969dba52018c2d64
Publikováno v:
PLoS Genetics, Vol 11, Iss 8, p e1005438 (2015)
Activation-induced cytidine deaminase (AID) is required for initiation of Ig class switch recombination (CSR) and somatic hypermutation (SHM) of antibody genes during immune responses. AID has also been shown to induce chromosomal translocations, mut
Externí odkaz:
https://doaj.org/article/1ba46d83f23443f490a3690fd7e007c6
Publikováno v:
PLoS Genetics, Vol 5, Iss 8, p e1000622 (2009)
The checkpoint kinases ATM and ATR are redundantly required for maintenance of stable telomeres in diverse organisms, including budding and fission yeasts, Arabidopsis, Drosophila, and mammals. However, the molecular basis for telomere instability in
Externí odkaz:
https://doaj.org/article/8cc54913dae542d4887e34f2810e67b2
Autor:
Louis M. Messina, Thomas Fazzio, Joonsoo Kang, April Deng, Julia A. Messina, Lyne Khair, Jinglian Yan, Guodong Tie
supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7049d568d5b540c0dab785e9c7b67fd8
https://doi.org/10.1158/0008-5472.22417503.v1
https://doi.org/10.1158/0008-5472.22417503.v1
Autor:
Louis M. Messina, Thomas Fazzio, Joonsoo Kang, April Deng, Julia A. Messina, Lyne Khair, Jinglian Yan, Guodong Tie
Obesity will soon surpass smoking as the most preventable cause of cancer. Hypercholesterolemia, a common comorbidity of obesity, has been shown to increase cancer risk, especially colorectal cancer. However, the mechanism by which hypercholesterolem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5754a0fdba6b91996d44c5f2a806b6b9
https://doi.org/10.1158/0008-5472.c.6509862
https://doi.org/10.1158/0008-5472.c.6509862
Autor:
Louis M. Messina, Thomas Fazzio, Joonsoo Kang, April Deng, Julia A. Messina, Lyne Khair, Jinglian Yan, Guodong Tie
supplementary methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d54a7898667a1c8279a8a8e8aa0a28
https://doi.org/10.1158/0008-5472.22417497.v1
https://doi.org/10.1158/0008-5472.22417497.v1
Autor:
Louis M. Messina, Thomas Fazzio, Joonsoo Kang, April Deng, Julia A. Messina, Lyne Khair, Jinglian Yan, Guodong Tie
This file contains 9 supplemental figures and one supplemental table in which we show that WT recipient mice reconstituted with HSCs from hypercholesterolemic ApoE-/- mice have normal serum cholesterol levels and white blood cell counts (S1); Hyperch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f27bf91ae6b5b0ffc7ecf2aa6816250
https://doi.org/10.1158/0008-5472.22417500.v1
https://doi.org/10.1158/0008-5472.22417500.v1
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Hypercholesterolemia accelerates the phenotypes of aging in hematopoietic stem cells (HSCs). As yet, little is known about the underlying mechanism. We found that hypercholesterolemia downregulates Ten eleven translocation 1 (Tet1) in HSCs. The total
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80917676e9676cc0a8f4a766a6c93eb1
https://doi.org/10.1038/s41598-020-60403-w
https://doi.org/10.1038/s41598-020-60403-w
Autor:
Lyne Khair, April Deng, Julia A. Messina, Joonsoo Kang, Guodong Tie, Thomas G. Fazzio, Jinglian Yan, Louis M. Messina
Publikováno v:
Cancer Research. 77:2351-2362
Obesity will soon surpass smoking as the most preventable cause of cancer. Hypercholesterolemia, a common comorbidity of obesity, has been shown to increase cancer risk, especially colorectal cancer. However, the mechanism by which hypercholesterolem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeab021da357134f8099d95256b29e65
https://doi.org/10.1158/0008-5472.can-16-1916
https://doi.org/10.1158/0008-5472.can-16-1916