Shortened tethering filaments stabilize presynaptic vesicles in support of elevated release probability during LTP in rat hippocampus

Autor: Kristen M. Harris, Jae Hoon Jung, Jennifer N. Bourne, Lyndsey M. Kirk

Publikováno v: Proc Natl Acad Sci U S A

Long-term potentiation (LTP) is a cellular mechanism of learning and memory that results in a sustained increase in the probability of vesicular release of neurotransmitter. However, previous work in hippocampal area CA1 of the adult rat revealed tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5596797db13de5bd645332cf80c08c7b
https://doi.org/10.1073/pnas.2018653118

SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function

Autor: Lyndsey M. Kirk, Kyle R. Puhger, David J. Speca, Michael C. Pride, Jill L. Silverman, Yael Stern-Bach, Lucas Matt, Johannes W. Hell, Jacqueline N. Crawley, Elva D Diaz, Tomer Haham, George Chenaux, Kristopher E. Plambeck, Mohammad Qneibi

Publikováno v: Cell Reports, Vol 22, Iss 9, Pp 2246-2253 (2018)
Cell reports, vol 22, iss 9

Summary: Altering AMPA receptor (AMPAR) content at synapses is a key mechanism underlying the regulation of synaptic strength during learning and memory. Previous work demonstrated that SynDIG1 (synapse differentiation-induced gene 1) encodes a trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56020d04c650ac22e8787f3f96585560
http://www.sciencedirect.com/science/article/pii/S2211124718301943

Deep Learning-Based Point-Scanning Super-Resolution Imaging

Autor: Sammy Weiser Novak, Kristen M. Harris, Kyle Kastner, Jeremy Howard, Uri Manor, Fred Monroe, Seungyoon B. Yu, Cara R. Schiavon, Lyndsey M. Kirk, Yoshiyuki Kubota, Linjing Fang, Melissa Wu, Tong Zhang, John M. Mendenhall, Zhao Zhang, Gulcin Pekkurnaz

Point scanning imaging systems (e.g. scanning electron or laser scanning confocal microscopes) are perhaps the most widely used tools for high resolution cellular and tissue imaging. Like all other imaging modalities, the resolution, speed, sample pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6376eda960d9b8a5594f560a4795301e

Activity-Dependent Palmitoylation Controls SynDIG1 Stability, Localization, and Function

Autor: Elva D Diaz, Kristopher E. Plambeck, Inderpreet Kaur, Eden V. Barragan, Eric S. Ontiveros, Lyndsey M. Kirk, Vladimir Yarov-Yarovoy

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 36, iss 29
Kaur, I; Yarov-Yarovoy, V; Kirk, LM; Plambeck, KE; Barragan, EV; Ontiveros, ES; et al.(2016). Activity-dependent palmitoylation controls synDIG1 stability, localization, and function. Journal of Neuroscience, 36(29), 7562-7568. doi: 10.1523/JNEUROSCI.4859-14.2016. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/74f5p0xr

UnlabelledSynapses are specialized contacts between neurons. Synapse differentiation-induced gene I (SynDIG1) plays a critical role during synapse development to regulate AMPA receptor (AMPAR) and PSD-95 content at excitatory synapses. Palmitoylation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c426a032d6f42b3a77c36297d4fe9d8
https://doi.org/10.1523/jneurosci.4859-14.2016

Distribution of the SynDIG4/proline-rich transmembrane protein 1 in rat brain

Autor: Mayra Orozco-Llamas, James S. Trimmer, Elva D Diaz, Lyndsey M. Kirk, Shu W. Ti, Michelle Pham, Hannah I. Bishop

Publikováno v: Journal of Comparative Neurology. 524:2266-2280

The modulation of AMPA receptor (AMPAR) content at synapses is thought to be an underlying molecular mechanism of memory and learning. AMPAR content at synapses is highly plastic and is regulated by numerous AMPAR accessory transmembrane proteins suc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::995cce52b55f150436f34af1717a4f22
https://doi.org/10.1002/cne.23945