Zobrazeno 1 - 10 of 53 pro vyhledávání: '"Lyndsey L Anderson"'
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Akademický článek
Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a+/- mouse model of Dravet syndrome.
Autor: Lyndsey L Anderson, Dilara A Bahceci, Nicole A Hawkins, Declan Everett-Morgan, Samuel D Banister, Jennifer A Kearney, Jonathon C Arnold
Publikováno v: PLoS ONE, Vol 18, Iss 1, p e0280842 (2023)
A purified preparation of cannabidiol (CBD), a cannabis constituent, has been approved for the treatment of intractable childhood epilepsies such as Dravet syndrome. Extensive pharmacological characterization of CBD shows activity at numerous molecul
Externí odkaz: https://doaj.org/article/bb7a769529cf4d5fb03fb7d3a0df6512
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2
Akademický článek
Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq.
Autor: Nicole A Hawkins, Nicole J Zachwieja, Alison R Miller, Lyndsey L Anderson, Jennifer A Kearney
Publikováno v: PLoS Genetics, Vol 12, Iss 10, p e1006398 (2016)
A substantial number of mutations have been identified in voltage-gated sodium channel genes that result in various forms of human epilepsy. SCN1A mutations result in a spectrum of severity ranging from mild febrile seizures to Dravet syndrome, an in
Externí odkaz: https://doaj.org/article/d719922279e249c58933622411345d98
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3
In Vitro Screening of Three Commercial Cannabis-Based Products on ATP-Binding Cassette and Solute-Carrier Transporter Function
Autor: Laura MacNair, Irina Mosesova, Jonathon C. Arnold, Maia G. Etchart, Lyndsey L. Anderson, M Hunter Land, Marcel O. Bonn-Miller
Publikováno v: Cannabis Cannabinoid Res
INTRODUCTION: Legalization of medicinal cannabis around the world has led to an increase in the use of commercial cannabis-based products in the community. These cannabis-based products are being used in combination with conventional drugs to treat a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecbf07f9f24deed5dd2ef2c3bbbf8d92
https://doi.org/10.1089/can.2020.0053
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5
MEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy
Autor: Thomas Harman, Michael Udoh, Dan L. McElroy, Lyndsey L. Anderson, Richard C. Kevin, Samuel D. Banister, Adam Ametovski, Jack Markham, Chris Bladen, Peter T. Doohan, Quentin Greba, Robert B. Laprairie, Terrance P. Snutch, Iain S. McGregor, John G. Howland, Jonathon C. Arnold
Publikováno v: Frontiers in Physiology. 14
Background: T-type Ca2+ channels (Cav3) represent emerging therapeutic targets for a range of neurological disorders, including epilepsy and pain. To aid the development and optimisation of new therapeutics, there is a need to identify novel chemical
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f791ae0889616470a1a4ce002ad7973
https://doi.org/10.3389/fphys.2023.1086243
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6
Evaluation of the Possible Anticonvulsant Effect of Δ9-Tetrahydrocannabinolic Acid in Murine Seizure Models
Autor: Ivan K. Low, Jia Lin Luo, Iain S. McGregor, Jonathon C. Arnold, Richard C. Kevin, Lyndsey L. Anderson, Melissa J. Benson, Cilla Zhou
Publikováno v: Cannabis and Cannabinoid Research. 7:46-57
Introduction: The cannabinoid Δ9-tetrahydrocannabinolic acid (Δ9-THCA) has long been suggested in review articles and anecdotal reports to be anticonvulsant; yet, there is scant evidence supporting this notion. The objective of this study was to in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ba6fe31183c653edd416a76469f5f8d
https://doi.org/10.1089/can.2020.0073
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7
Beyond CBD: Inhibitory effects of lesser studied phytocannabinoids on human voltage-gated sodium channels
Autor: Carol J. Milligan, Lyndsey L. Anderson, Iain S. McGregor, Jonathon C. Arnold, Steven Petrou
Publikováno v: Frontiers in Physiology. 14
Introduction: Cannabis contains cannabidiol (CBD), the main non-psychoactive phytocannabinoid, but also many other phytocannabinoids that have therapeutic potential in the treatment of epilepsy. Indeed, the phytocannabinoids cannabigerolic acid (CBGA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b33aaa9ff4556ce54722d3a3ef7e325
https://doi.org/10.3389/fphys.2023.1081186
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Cannabigerolic acid, a major biosynthetic precursor molecule in cannabis, exhibits divergent effects on seizures in mouse models of epilepsy
Autor: Nicole A. Hawkins, Jonathon C. Arnold, Michael T. Bowen, Jennifer A. Kearney, Mary Chebib, Fan Zhang, Iain S. McGregor, Marika Heblinski, Dilara Bahceci, Lyndsey L. Anderson, Nathan L. Absalom, Melissa J. Benson, Peter T. Doohan
Publikováno v: British Journal of Pharmacology. 178:4826-4841
Background and purpose Cannabis has been used to treat epilepsy for millennia, with such use validated by regulatory approval of cannabidiol (CBD) for the treatment of Dravet syndrome. Unregulated artisanal cannabis-based products used to treat child
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8c25387e476a6d533a396b6aac6596
https://doi.org/10.1111/bph.15661
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10
Citalopram and Cannabidiol
Autor: Richard C. Kevin, Jonathon C. Arnold, Iain S. McGregor, Peter T. Doohan, Lyndsey L. Anderson, Maximus Berger, G. Paul Amminger, Lachlan D. Oldfield
Publikováno v: Journal of Clinical Psychopharmacology. 41:525-533
Background Cannabidiol (CBD), a major nonintoxicating constituent of cannabis, exhibits anxiolytic properties in preclinical and human studies and is of interest as a novel intervention for treating anxiety disorders. Existing first-line pharmacother
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c94e1ff6c1432a225987a40b98613aa
https://doi.org/10.1097/jcp.0000000000001427
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