NeuroSAFE PROOF: study protocol for a single-blinded, IDEAL stage 3, multi-centre, randomised controlled trial of NeuroSAFE robotic-assisted radical prostatectomy versus standard robotic-assisted radical prostatectomy in men with localized prostate cancer

Autor: Eoin Dinneen, Jack Grierson, Ricardo Almeida-Magana, Rosie Clow, Aiman Haider, Clare Allen, Daniel Heffernan-Ho, Alex Freeman, Tim Briggs, Senthil Nathan, Susan Mallett, Chris Brew-Graves, Nicola Muirhead, Norman R. Williams, Elena Pizzo, Raj Persad, Jon Aning, Lyndsey Johnson, Jon Oxley, Neil Oakley, Susan Morgan, Fawzia Tahir, Imran Ahmad, Lorenzo Dutto, Jonathan M. Salmond, Anand Kelkar, John Kelly, Greg Shaw

Publikováno v: Trials, Vol 23, Iss 1, Pp 1-16 (2022)

Abstract Background Robotic radical prostatectomy (RARP) is a first-line curative treatment option for localized prostate cancer. Postoperative erectile dysfunction and urinary incontinence are common associated adverse side effects that can negative

Externí odkaz: https://doaj.org/article/2ca9684b459c4f83ad3d1d0f316d5b40

Results of a randomized, double blind, placebo controlled, crossover trial of melatonin for treatment of Nocturia in adults with multiple sclerosis (MeNiMS)

Autor: Marcus J. Drake, Luke Canham, Nikki Cotterill, Debbie Delgado, Jenny Homewood, Kirsty Inglis, Lyndsey Johnson, Mary C. Kisanga, Denise Owen, Paul White, David Cottrell

Publikováno v: BMC Neurology, Vol 18, Iss 1, Pp 1-8 (2018)

Abstract Background Nocturia is a common urinary symptom of multiple sclerosis (MS) which can affect quality of life (QoL) adversely. Melatonin is a hormone known to regulate circadian rhythm and reduce smooth muscle activity such as in the bladder.

Externí odkaz: https://doaj.org/article/0e91c7e63abd44d6bd6fe2e9d5c43361

Prostate cancer-Exercise and Metformin Trial (Pre-EMpT): study protocol for a feasibility factorial randomized controlled trial in men with localised or locally advanced prostate cancer

Autor: Lucy McGeagh, Luke A. Robles, Raj Persad, Edward Rowe, Amit Bahl, Jonathan Aning, Anthony Koupparis, Paul Abrams, Claire Perks, Jeffrey Holly, Lyndsey Johnson, Constance Shiridzinomwa, Amarnath Challapalli, Ellie Shingler, Hilary Taylor, Jon Oxley, Meda Sandu, Richard M. Martin, J. Athene Lane

Publikováno v: Pilot and feasibility studies. 8(1)

Background Evidence from observational studies have shown that moderate intensity physical activity can reduce risk of progression and cancer-specific mortality in participants with prostate cancer. Epidemiological studies have also shown participant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a814f5ab4fac86cacec56ab780cd1a
https://pubmed.ncbi.nlm.nih.gov/35962445

Thulium laser transurethral vaporesection of the prostate versus transurethral resection of the prostate for men with lower urinary tract symptoms or urinary retention (UNBLOCS): a randomised controlled trial

Autor: Sara T Brookes, Paul Abrams, Benita Adams, Nicholas Cohen, J. Athene Lane, Angela J. Allan, Lyndsey Johnson, Jo Worthington, Chris Metcalfe, Hilary Taylor, Jonathan Sullivan, Tobias Page, Aideen Ahern, Sian Noble, Joan Henderson, Paula Hilltout, Kim Davenport, Carol Brain, Christopher Blake, Leigh Morrison, Wendy Robson, Christopher Pawsey, Bernadette Kilbane, Rupert Beck, Oliver Kayes, Julie Plant, Rafiyah Khan, Anthony G. Timoney, Fiona Hammonds, Grace J. Young, Mai Baquedano, Aida Moure Fernandez, Tom Steuart-Feilding, Nikki Cotterill, Hashim Hashim, Alan D. Uren, K. Satchi Swami, Vivian Zinyemba, Mathialagan Murugesan, Lorraine Wiseman, David Carmichael, Barbara Warnes

Publikováno v: Lancet (London, England)

Summary Background Transurethral resection of the prostate (TURP) is the standard operation for benign prostatic obstruction. Thulium laser transurethral vaporesection of the prostate (ThuVARP) is a technique with suggested advantages over TURP, incl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b73db0cded00063ec6fd9afd7d9c9bf
https://pubmed.ncbi.nlm.nih.gov/33309032

Phase II randomised control feasibility trial of a nutrition and physical activity intervention after radical prostatectomy for prostate cancer

Autor: Raj Persad, Aleksandra Frankow, Edward Rowe, J. Athene Lane, Claire M Perks, Constance Shiridzinomwa, Jayne V. Woodside, Jeffrey M P Holly, Richard M. Martin, Lyndsey Johnson, Ellie Shingler, Jon Oxley, Kalina Biernacka, Lucy E Hackshaw-McGeagh, Anthony Koupparis, Amit Bahl, Chris Penfold, Luke A Robles, Paul Abrams, Sarah Gilchrist

Publikováno v: Hackshaw-McGeagh, L E, Penfold, C, Shingler, E, Robles, L A, Perks, C M, Holly, J M P, Rowe, E, Koupparis, A, Bahl, A, Persad, R, Shiridzinomwa, C, Johnson, L, Biernacka, K M, Frankow, A, Woodside, J V, Gilchrist, S, Oxley, J, Abrams, P, Lane, J A & Martin, R M 2019, ' Phase II randomised control feasibility trial of a nutrition and physical activity intervention after radical prostatectomy for prostate cancer ', BMJ Open, vol. 9, no. 11, e029480 . https://doi.org/10.1136/bmjopen-2019-029480
BMJ Open
Hackshaw-McGeagh, L, Penfold, C, Shingler, E, Robles, L A, Perks, C M, Holly, J M P, Rowe, E, Koupparis, A J, Bahl, A, Persad, R A, Shiridzinomwa, C, Johnson, L, Biernacka, K, Frankow, A, Woodside, J V, Gilchrist, S, Oxley, J D, Abrams, P H, Lane, J A & Martin, R M 2019, ' Phase II randomised control feasibility trial of a nutrition and physical activity intervention after radical prostatectomy for prostate cancer ', BMJ Open, vol. 9, no. 11, e029480 . https://doi.org/10.1136/bmjopen-2019-029480

ObjectiveDietary factors and physical activity may alter prostate cancer progression. We explored the feasibility of lifestyle interventions following radical prostatectomy for localised prostate cancer.DesignPatients were recruited into a presurgica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d495c23ec8b93acce3223adcd596eba
https://pure.qub.ac.uk/en/publications/7fda6e5d-9e62-4950-994b-e494dfbd98c3