Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Lyndsay Smith"'
Autor:
Jeremy Chang, Marcus Soliai, Connor Barnhill, Lyndsay Smith, Arun Mathew, Alexander Apostolov, Ben Dulken, Aleksandr Petukhov, Ananth Sridhar, Caroline Gorvin, Christoph Lange, Russ Altman, Scott Adler, Mary Scott Roberts, Jonathan Fox, Sun-Gou Ji
Publikováno v:
Genetics in Medicine Open, Vol 2, Iss , Pp 101058- (2024)
Externí odkaz:
https://doaj.org/article/8a79c8b841824963ad8ada9ff47908e8
Autor:
Arun Mathew, Ananth Sridhar, Mary Scott Roberts, Lyndsay Smith, Scott Adler, Michael Mannstadt
Publikováno v:
Genetics in Medicine Open, Vol 2, Iss , Pp 101151- (2024)
Externí odkaz:
https://doaj.org/article/0c02df9bb7414713819568840b3231eb
Autor:
Manikandan Palrasu, Anna M. Knapinska, Juan Diez, Lyndsay Smith, Travis LaVoi, Mac Giulianotti, Richard A. Houghten, Gregg B. Fields, Dmitriy Minond
Publikováno v:
Cellular Physiology and Biochemistry, Vol 53, Iss 4, Pp 656-686 (2019)
Externí odkaz:
https://doaj.org/article/0badd010127e4b48b2a91a8683dd94db
Autor:
Juan Diez, Lyndsay Smith, Anna M. Knapinska, Manikandan Palrasu, Travis LaVoi, Gregg B. Fields, Marc A. Giulianotti, Richard A. Houghten, Dmitriy Minond
Publikováno v:
Cellular Physiology and Biochemistry, Vol 53, Iss 4, Pp 656-686 (2019)
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Background/aims Despite recent advances in melanoma drug discovery, the average overall survival of patients with late stage metastatic melanoma is approximately 3 years, suggesting a need for approaches that identify new melanoma targets. We have pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5c664d1e7b28a7f521378e7866e7ec
https://www.cellphysiolbiochem.com/Articles/000164/
https://www.cellphysiolbiochem.com/Articles/000164/
Autor:
William R. Roush, Rita Fuerst, Gregg B. Fields, Anna M. Knapinska, Claudia Ruiz, Lyndsay Smith, Jun Yong Choi, Michael D. Cameron
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:4984-4995
A structure-activity/structure-property relationship study based on the physicochemical as well as in vitro pharmacokinetic properties of a first generation matrix metalloproteinase (MMP)-13 inhibitor (2) was undertaken. After systematic variation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08fae9a119450fcde47713ae64a70b2a
https://doi.org/10.1016/j.bmc.2018.08.020
https://doi.org/10.1016/j.bmc.2018.08.020
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1864:1940-1951
The proteolytic processing of collagen (collagenolysis) is critical in development and homeostasis, but also contributes to numerous pathologies. Mammalian interstitial collagenolytic enzymes include members of the matrix metalloproteinase (MMP) fami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab0a2b78fae3a704f6372902f373c7c
https://doi.org/10.1016/j.bbamcr.2017.04.015
https://doi.org/10.1016/j.bbamcr.2017.04.015
Autor:
Stéphane P. Roche, Nagalakshmi Jeedimalla, Madison Flint, Lyndsay Smith, Dmitriy Minond, Alberto Haces
Publikováno v:
European Journal of Medicinal Chemistry. 106:167-179
The aim of this study was the synthesis and lead structure selection of a best anti-leukemic agent from a library of aza-podophyllotoxin analogues (APTs). To this end, we report a scalable, modified multicomponent reaction using a "sacrificial" anili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0487e34797d88531573d6b34be7d7f36
https://doi.org/10.1016/j.ejmech.2015.10.009
https://doi.org/10.1016/j.ejmech.2015.10.009
Publikováno v:
Rheumatology. 56
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60e58a2ca410f72d5e3e644eeab14c0c
https://doi.org/10.1093/rheumatology/kex356.020
https://doi.org/10.1093/rheumatology/kex356.020
Autor:
Lyndsay Smith, Gregg B. Fields, Xiaohang Cao, Anna M. Knapinska, Jun Yong Choi, Alexander B. Taylor, William R. Roush, P. John Hart, Rita Fuerst
Publikováno v:
Journal of medicinal chemistry. 60(13)
We describe the use of comparative structural analysis and structure-guided molecular design to develop potent and selective inhibitors (10d and (S)-17b of matrix metalloproteinase 13 (MMP-13). We applied a three-step process, starting with a compara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d99e9e0c30b7f36094800e526f369d1
https://pubmed.ncbi.nlm.nih.gov/28653849
https://pubmed.ncbi.nlm.nih.gov/28653849
Autor:
Richard A. Houghten, Gregg B. Fields, Dmitriy Minond, Lisa Tack, Gaurav Kaushik, Marc A. Giulianotti, Anna M. Knapinska, Travis LaVoi, Lillian Onwuha-Ekpete, Lyndsay Smith
Publikováno v:
Journal of Medicinal Chemistry
A common liability of cancer drugs is toxicity to noncancerous cells. Thus, molecules are needed that are potent toward cancer cells while sparing healthy cells. The cost of traditional cell-based HTS is dictated by the library size, which is typical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0492fc3c442119d200463e10d1b9ddb
https://doi.org/10.1021/jm4019542
https://doi.org/10.1021/jm4019542