Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lyndsay Olson"'
Autor:
John D. Belcher, Selvaraj Nataraja, Fuad Abdulla, Ping Zhang, Chunsheng Chen, Julia Nguyen, Conglin Ruan, Maneet Singh, Shilpa Demes, Lyndsay Olson, Domi Stickens, Jeff Stanwix, Emer Clarke, Yongzhao Huang, Margaret Biddle, Gregory M. Vercellotti
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
In sickle cell disease (SCD), heme released during intravascular hemolysis promotes oxidative stress, inflammation, and vaso-occlusion. Conversely, free heme can also activate expression of antioxidant and globin genes. Heme binds to the transcriptio
Externí odkaz:
https://doaj.org/article/08d36bbf537a4d62b4156a1ffb787feb
Autor:
Bharat Lagu, Xinyuan Wu, Santosh Kulkarni, Rakesh Paul, J. David Becherer, Lyndsay Olson, Stella Ravani, Athanasia Chatzianastasiou, Andreas Papapetropoulos, Sylvia Andrzejewski
Publikováno v:
Journal of Medicinal Chemistry. 65:9418-9446
Autor:
Ross Fredenburg, Matthew M. Goddeeris, Jennifer K Truong, Effie Tozzo, Dominique Stickens, Robert W. Shine, Eric L. Bell, Peter Dwyer, Lyndsay Olson
Publikováno v:
Mitochondrion. 46:51-58
Duchenne muscular dystrophy (DMD) is a recessive, fatal X-linked disease that is characterized by progressive skeletal muscle wasting due to the absence of dystrophin, which is an a essential protein that bridges the inner cytoskeleton and extra-cell
Autor:
Selva Nataraja, Jeff Stanwix, Fuad Abdulla, Shilpa Demes, Emer Clarke, Maneet Singh, Julia Nguyen, Chunsheng Chen, John D. Belcher, Gregory M. Vercellotti, Margaret Biddle, Yongzhao Huang, Ping Zhang, Lyndsay Olson
Publikováno v:
Blood. 138:854-854
Sickle cell disease (SCD) is a genetic disorder caused by a point mutation in the β-globin subunit resulting in hemoglobin S (HbS). Following deoxygenation of red blood cells, HbS forms polymers that can promote hemolysis and the release of free hem
Autor:
Jacob Lloyd, Fuad Abdulla, Eric L. Bell, Gregory M. Vercellotti, Domi Stickens, Zachary Monroe Kiser, Chunsheng Chen, Margaret Biddle, John D. Belcher, Lyndsay Olson, Julia Nguyen
Publikováno v:
Blood. 134:983-983
In sickle cell disease (SCD) excessive release of Hb and heme into the vasculature can activate innate immune toll-like receptor 4 (TLR4) signaling in the vasculature leading to inflammation and vaso-occlusion. Heme-mediated TLR4 signaling can be int