Safety of photosynthetic Synechococcus elongatus for in vivo cyanobacteria–mammalian symbiotic therapeutics

Autor: Kiah M. Williams, Hanjay Wang, Michael J. Paulsen, Akshara D. Thakore, Mary Rieck, Haley J. Lucian, Frederick Grady, Camille E. Hironaka, Athena J. Chien, Justin M. Farry, Hye Sook Shin, Kevin J. Jaatinen, Anahita Eskandari, Lyndsay M. Stapleton, Amanda N. Steele, Jeffrey E. Cohen, Y. Joseph Woo

Publikováno v: Microbial Biotechnology, Vol 13, Iss 6, Pp 1780-1792 (2020)

Summary The cyanobacterium Synechococcus elongatus (SE) has been shown to rescue ischaemic heart muscle after myocardial infarction by photosynthetic oxygen production. Here, we investigated SE toxicity and hypothesized that systemic SE exposure does

Externí odkaz: https://doaj.org/article/c784836fb5084c97bc1d9b5ca0395c84

Tissue-engineered smooth muscle cell and endothelial progenitor cell bi-level cell sheets prevent progression of cardiac dysfunction, microvascular dysfunction, and interstitial fibrosis in a rodent model of type 1 diabetes-induced cardiomyopathy

Autor: Masashi Kawamura, Michael J. Paulsen, Andrew B. Goldstone, Yasuhiro Shudo, Hanjay Wang, Amanda N. Steele, Lyndsay M. Stapleton, Bryan B. Edwards, Anahita Eskandari, Vi N. Truong, Kevin J. Jaatinen, Arnar B. Ingason, Shigeru Miyagawa, Yoshiki Sawa, Y. Joseph Woo

Publikováno v: Cardiovascular Diabetology, Vol 16, Iss 1, Pp 1-17 (2017)

Abstract Background Diabetes mellitus is a risk factor for coronary artery disease and diabetic cardiomyopathy, and adversely impacts outcomes following coronary artery bypass grafting. Current treatments focus on macro-revascularization and neglect

Externí odkaz: https://doaj.org/article/afb712d975624ddf90ce2a72da3a2963

Autosomal Dominant Hypocalcemia Type 1: A Systematic Review

Autor: Kelly L Roszko, Lyndsay M Stapleton Smith, Ananth V Sridhar, Mary Scott Roberts, Iris R Hartley, Rachel I Gafni, Michael T Collins, Jonathan C Fox, Edward F Nemeth

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 37(10)

Autosomal dominant hypocalcemia type 1 (ADH1) is a rare form of hypoparathyroidism due to activating variants of the calcium-sensing receptor gene (CASR). Inherited or de novo activating variants of the CASR alter the set point for extracellular calc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd552a16a94cbaa8631b592fa3b9c549
https://pubmed.ncbi.nlm.nih.gov/35879818

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A co-formulation of supramolecularly stabilized insulin and pramlintide enhances mealtime glucagon suppression in diabetic pigs

Autor: Anton A. A. Smith, Abigail K. Grosskopf, Eric A. Appel, Gillie A. Roth, Santiago Correa, Doreen Chan, Sam W. Baker, David M. Maahs, Caitlin L. Maikawa, Celine Liong, Bruce A. Buckingham, Lyndsay M. Stapleton, Joseph L. Mann, Catherine M. Meis, Megan L. Troxell, Lei Zou, Emily C. Gale, Matthew J. Webber, Anthony C. Yu

Publikováno v: Maikawa, C L, Smith, A A A, Zou, L, Roth, G A, Gale, E C, Stapleton, L M, Baker, S W, Mann, J L, Yu, A C, Correa, S, Grosskopf, A K, Liong, C S, Meis, C M, Chan, D, Troxell, M, Maahs, D M, Buckingham, B A, Webber, M J & Appel, E A 2020, ' A co-formulation of supramolecularly stabilized insulin and pramlintide enhances mealtime glucagon suppression in diabetic pigs ', Nature Biomedical Engineering, vol. 4, no. 5, pp. 507-517 . https://doi.org/10.1038/s41551-020-0555-4
Nature biomedical engineering

Treatment of patients with diabetes with insulin and pramlintide (an amylin analogue) is more effective than treatment with insulin only. However, because mixtures of insulin and pramlintide are unstable and have to be injected separately, amylin ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38a8437a8df2950b7ad393d07a2dc88
https://doi.org/10.1038/s41551-020-0555-4