Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lyndsay M. Murrow"'
Autor:
Lyndsay M. Murrow, Robert J. Weber, Joseph A. Caruso, Christopher S. McGinnis, Kiet Phong, Philippe Gascard, Gabrielle Rabadam, Alexander D. Borowsky, Tejal A. Desai, Matthew Thomson, Thea Tlsty, Zev J. Gartner
Publikováno v:
Cell systems, vol 13, iss 8
The rise and fall of estrogen and progesterone across menstrual cycles and during pregnancy regulates breast development and modifies cancer risk. How these hormones impact each cell type in the breast remains poorly understood because they act indir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5befbb7d01e0de6c4c444c92e3fae2e
https://resolver.caltech.edu/CaltechAUTHORS:20220720-918411000
https://resolver.caltech.edu/CaltechAUTHORS:20220720-918411000
Autor:
Zev J. Gartner, Lyndsay M. Murrow
Publikováno v:
Developmental Cell. 51:545-547
In this issue of Developmental Cell, Niwayama et al. (2019) describe a model in which cell polarity and cell shape compete to determine the orientation of cell division in the pre-implantation mouse embryo. This model explains how simple cell-intrins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9efdd8ab9603bd9255a3bd0d35613644
https://doi.org/10.1016/j.devcel.2019.11.008
https://doi.org/10.1016/j.devcel.2019.11.008
Publikováno v:
Development. 144:998-1007
For many tissues, single resident stem cells grown in vitro under appropriate three-dimensional conditions can produce outgrowths known as organoids. These tissues recapitulate much of the cell composition and architecture of the in vivo organ from w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ddca152a4a9cac297295224f7906cf
https://doi.org/10.1242/dev.140905
https://doi.org/10.1242/dev.140905
Autor:
Alexander D. Borowsky, Tejal A. Desai, Robert J. Weber, Thea D. Tlsty, Christopher S. McGinnis, Matt Thomson, Joseph A. Caruso, Philippe Gascard, Kiet T. Phong, Zev J. Gartner, Lyndsay M. Murrow
The human breast undergoes lifelong remodeling in response to estrogen and progesterone, but hormone exposure also increases breast cancer risk. Here, we use single-cell analysis to identify distinct mechanisms through which breast composition and ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08ad6f9cc5a9b047f9394270154e159a
https://doi.org/10.1101/430611
https://doi.org/10.1101/430611
Autor:
Marco Y. Hein, Eric D. Chow, Jennifer L. Hu, Daniel N. Conrad, Lyndsay M. Murrow, Vasudha Srivastava, David M. Patterson, Christopher S. McGinnis, Jonathan S. Weissman, Juliane Winkler, Zev J. Gartner, Zena Werb
Publikováno v:
Nature methods. 16(7)
Sample multiplexing facilitates scRNA-seq by reducing costs and artifacts such as cell doublets. However, universal and scalable sample barcoding strategies have not been described. We therefore developed MULTI-seq: multiplexing using lipid-tagged in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca015265a11868b9a1765f484069ac8f
https://pubmed.ncbi.nlm.nih.gov/31209384
https://pubmed.ncbi.nlm.nih.gov/31209384
Publikováno v:
Debnath, Jayanta; Murrow, L; & Malhotra, R. (2015). ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/7236b521
Nature cell biology
Nature cell biology
The ubiquitin-like molecule ATG12 is required for the early steps of autophagy. Recently, we identified ATG3, the E2-like enzyme required for LC3 lipidation during autophagy, as an ATG12 conjugation target. Here, we demonstrate that cells lacking ATG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52b6b182b22337b0e5def26466dc212
https://doi.org/10.1038/ncb3112
https://doi.org/10.1038/ncb3112
Publikováno v:
Cell systems, vol 8, iss 4
SUMMARYSingle-cell RNA sequencing (scRNA-seq) using droplet microfluidics occasionally produces transcriptome data representing more than one cell. These technical artifacts are caused by cell doublets formed during cell capture and occur at a freque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7c6a695ba175e3f25f665c2e15c1aa
https://doi.org/10.1016/j.cels.2019.03.003
https://doi.org/10.1016/j.cels.2019.03.003
Autor:
Jayanta Debnath, Lyndsay M. Murrow
Publikováno v:
Molecular Cell. 57(3):393-395
In this issue of Molecular Cell, Huang et al. (2015) describe a nuclear pool of LC3 that is deacetylated during starvation, leading to redistribution of this essential autophagy regulator to the cytoplasm, where it can initiate autophagy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b4c65db2e52b152dba6da1c5ccdc57
Autor:
Christopher Fung, Jayanta Debnath, Estefania Fernandez, Srirupa Roy, Lilliana Radoshevich, Nan Chen, Lyndsay M. Murrow
Publikováno v:
Cell. 142:590-600
SummaryATG12, an ubiquitin-like modifier required for macroautophagy, has a single known conjugation target, another autophagy regulator called ATG5. Here, we identify ATG3 as a substrate for ATG12 conjugation. ATG3 is the E2-like enzyme necessary fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6e73b2ed3123b3b13ad79a2fc8a1d6
https://doi.org/10.1016/j.cell.2010.07.018
https://doi.org/10.1016/j.cell.2010.07.018
Autor:
Lyndsay M. Murrow, Jayanta Debnath
Publikováno v:
Molecular & Cellular Oncology. 5:e1039191
We recently identified an interaction between Atg12–Atg3, a complex between 2 core autophagy regulators, and the ESCRT-associated protein Pdcd6ip (programmed cell death 6 interacting protein, commonly known as Alix), which coordinately regulates ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd387e7b8bd6a83cc0d4f9a43ae01bb7
https://doi.org/10.1080/23723556.2015.1039191
https://doi.org/10.1080/23723556.2015.1039191