Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lyndsay L. Leach"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Ocular diseases resulting in death of the retinal pigment epithelium (RPE) lead to vision loss and blindness. There are currently no FDA-approved strategies to restore damaged RPE cells. Stimulating intrinsic regenerative responses within da
Externí odkaz:
https://doaj.org/article/d3e84d7bb19b4827a56950fbb7a82410
Publikováno v:
PLoS Genetics, Vol 18, Iss 3, p e1009628 (2022)
The retinal pigment epithelium (RPE) plays numerous critical roles in maintaining vision and this is underscored by the prevalence of degenerative blinding diseases like age-related macular degeneration (AMD), in which visual impairment is caused by
Externí odkaz:
https://doaj.org/article/4ff72f4de9d74fe38249630f8e4489f1
Autor:
Nicholas J Hanovice, Lyndsay L Leach, Kayleigh Slater, Ana E Gabriel, Dwight Romanovicz, Enhua Shao, Ross Collery, Edward A Burton, Kira L Lathrop, Brian A Link, Jeffrey M Gross
Publikováno v:
PLoS Genetics, Vol 15, Iss 1, p e1007939 (2019)
The retinal pigment epithelium (RPE) is a specialized monolayer of pigmented cells within the eye that is critical for maintaining visual system function. Diseases affecting the RPE have dire consequences for vision, and the most prevalent of these i
Externí odkaz:
https://doaj.org/article/773a2271180d4bd0950ffb0b65f6dfa8
Publikováno v:
J Vis Exp
The retinal pigment epithelium (RPE) resides at the back of the eye and performs functions essential for maintaining the health and integrity of adjacent retinal and vascular tissues. At present, the limited reparative capacity of mammalian RPE, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1dbbb42a58fae097f9d79197d6968d0
https://doi.org/10.3791/63658
https://doi.org/10.3791/63658
The retinal pigment epithelium (RPE) plays numerous critical roles in maintaining vision and this is underscored by the prevalence of degenerative blinding diseases like age-related macular degeneration (AMD), in which visual impairment is caused by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7aff38f59192912b37f441e3ab5fe57d
https://doi.org/10.1101/2021.06.01.446531
https://doi.org/10.1101/2021.06.01.446531
Autor:
Lyndsay L. Leach, Stephanie M. George, Nicholas J. Hanovice, Ana E. Gabriel, Jeffrey M. Gross
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Loss of the retinal pigment epithelium (RPE) because of dysfunction or disease can lead to blindness in humans. Harnessing the intrinsic ability of the RPE to self-repair is an attractive therapeutic strategy; however, mammalian RPE is limited in its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c789ba4a5ff688e8da2bbecad2b9657
https://doi.org/10.1073/pnas.2017198118
https://doi.org/10.1073/pnas.2017198118
Publikováno v:
Prog Retin Eye Res
Diseases that result in retinal pigment epithelium (RPE) degeneration, such as age-related macular degeneration (AMD), are among the leading causes of blindness worldwide. Atrophic (dry) AMD is the most prevalent form of AMD and there are currently n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7603cb1cec12c67b4d9ada5c4a4052
https://doi.org/10.1016/j.preteyeres.2021.100969
https://doi.org/10.1016/j.preteyeres.2021.100969
Autor:
Kira L. Lathrop, Ana E. Gabriel, Nicholas J. Hanovice, Lyndsay L. Leach, Edward A. Burton, Brian A. Link, Jeffrey M. Gross, Dwight K. Romanovicz, Enhua Shao, Kayleigh Slater, Ross F Collery
Publikováno v:
PLoS Genetics, Vol 15, Iss 1, p e1007939 (2019)
PLoS Genetics
PLoS Genetics
The retinal pigment epithelium (RPE) is a specialized monolayer of pigmented cells within the eye that is critical for maintaining visual system function. Diseases affecting the RPE have dire consequences for vision, and the most prevalent of these i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdce8981f6cfa2834d0c94efa9e7557
https://doi.org/10.1371/journal.pgen.1007939
https://doi.org/10.1371/journal.pgen.1007939
Autor:
Britney O Pennington, Tracy N Clevenger, Vignesh P. Nadar, Qirui Hu, Dennis O. Clegg, David M. Gamm, Roxanne H. Croze, Lyndsay L. Leach
Publikováno v:
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 32(5)
The application of induced pluripotent stem cell-derived retinal pigmented epithelium (iPSC-RPE) in patients with retinal degenerative disease is making headway toward the clinic, with clinical trials already underway. Multiple groups have developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9162e69a3faf9faccae44a8641cc8f
https://pubmed.ncbi.nlm.nih.gov/27182743
https://pubmed.ncbi.nlm.nih.gov/27182743
Publikováno v:
Neuroscience. 189:123-131
Purpose. To determine the role of TGF-β1 in the maintenance of retinal ganglion cell line (RGC-5) differentiation and integrity. Methods. RGC-5 cells were differentiated in media conditioned by human non-pigmented ciliary epithelial cells (HNPE) for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca88fb3459114c29b76ea677211a500
https://doi.org/10.1016/j.neuroscience.2011.05.020
https://doi.org/10.1016/j.neuroscience.2011.05.020