Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lyndsay Kerr"'
Publikováno v:
PLoS Genetics, Vol 19, Iss 10, p e1010958 (2023)
High-throughput sequencing technology is central to our current understanding of the human methylome. The vast majority of studies use chemical conversion to analyse bulk-level patterns of DNA methylation across the genome from a population of cells.
Externí odkaz:
https://doaj.org/article/d6c79d47792e42afa12ff1bf04da04d7
Autor:
Jonathan Higham, Lyndsay Kerr, Qian Zhang, Rosie M. Walker, Sarah E. Harris, David M. Howard, Emma L. Hawkins, Anca-Larisa Sandu, J. Douglas Steele, Gordon D. Waiter, Alison D. Murray, Kathryn L. Evans, Andrew M. McIntosh, Peter M. Visscher, Ian J. Deary, Simon R. Cox, Duncan Sproul
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-28 (2022)
Abstract Background DNA methylation is an epigenetic mark associated with the repression of gene promoters. Its pattern in the genome is disrupted with age and these changes can be used to statistically predict age with epigenetic clocks. Altered rat
Externí odkaz:
https://doaj.org/article/4a8ed727d825483db65eb461688f51e5
Autor:
Francesca Taglini, Ioannis Kafetzopoulos, Kamila Irena Musialik, Heng Yang Lee, Yujie Zhang, Mattia Marenda, Lyndsay Kerr, Hannah Finan, Cristina Rubio-Ramon, Hannah Wapenaar, Hazel Davidson-Smith, Jimi Wills, Laura C. Murphy, Ann Wheeler, Marcus D. Wilson, Duncan Sproul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48a3598c2845997b3215f05c48b077c8
https://doi.org/10.15252/rc.2023033342
https://doi.org/10.15252/rc.2023033342
Autor:
Francesca Taglini, Ioannis Kafetzopoulos, Kamila Irena Musialik, Heng Yang Lee, Yujie Zhang, Mattia Marenda, Lyndsay Kerr, Hannah Finan, Cristina Rubio-Ramon, Hannah Wapenaar, Hazel Davidson-Smith, Jimi Wills, Laura C. Murphy, Ann Wheeler, Marcus D. Wilson, Duncan Sproul
The correct establishment of DNA methylation patterns is vital for mammalian development and is achieved largely by thede novoDNA methyltransferases DNMT3A and DNMT3B. Mutations in DNMT3B can cause immunodeficiency-centromeric instability-facial anom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c22ce566163857a20eae89f21802fef2
https://doi.org/10.1101/2022.12.19.521050
https://doi.org/10.1101/2022.12.19.521050
High-throughput sequencing technology is central to our current understanding of the human methylome. The vast majority of studies use chemical conversion to analyse bulk-level patterns of DNA methylation across the genome from a population of cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2e7033f2d955bb2bf68c63d90d407d6
https://doi.org/10.1101/2022.11.15.516549
https://doi.org/10.1101/2022.11.15.516549
Publikováno v:
Journal of the Royal Society Interface
Kerr, L, Sproul, D & Grima, R 2022, ' Cluster mean-field theory accurately predicts statistical properties of large-scale DNA methylation patterns ', Journal of the Royal Society. Interface, vol. 19, no. 186, 20210707 . https://doi.org/10.1098/rsif.2021.0707
Kerr, L, Sproul, D & Grima, R 2022, ' Cluster mean-field theory accurately predicts statistical properties of large-scale DNA methylation patterns ', Journal of the Royal Society. Interface, vol. 19, no. 186, 20210707 . https://doi.org/10.1098/rsif.2021.0707
The accurate establishment and maintenance of DNA methylation patterns is vital for mammalian development and disruption to these processes causes human disease. Our understanding of DNA methylation mechanisms has been facilitated by mathematical mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30969350a2cf7906b61c65d2d7ef6dda
http://europepmc.org/articles/PMC8790364
http://europepmc.org/articles/PMC8790364
We investigate an infinite, linear system of ordinary differential equations that models the evolution of fragmenting clusters. We assume that each cluster is composed of identical units (monomers) and we allow mass to be lost, gained or conserved du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1e9353356e18f88129459f4f913e22