Biologics in Cervical Cancer Therapy

Autor: Daniele A. Sumner, Lyndsay J. Willmott, Bradley J. Monk

Publikováno v: Journal of the National Comprehensive Cancer Network. 8:1417-1423

Though cervical cancer incidence and prevalence have decreased in the United States, the disease remains a very important cause of morbidity and mortality worldwide. Current therapy for early-stage disease is surgical with adjuvant therapy being admi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b54b272d4a140064791142581da155
https://doi.org/10.6004/jnccn.2010.0105

Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture

Autor: Lyndsay J. Willmott, Valerie Trapp, Basmina Parmakhtiar, John P. Fruehauf, Vartan Papazian

Publikováno v: Trapp, V; Parmakhtiar, B; Papazian, V; Willmott, L; & Fruehauf, JP. (2010). Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture. Angiogenesis, 13(4), 305-315. doi: 10.1007/s10456-010-9187-8. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4939p5cg
Trapp, Valerie; Parmakhtiar, Basmina; Papazian, Vartan; Willmott, Lyndsay; & Fruehauf, John P.(2010). Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture. Angiogenesis, 13(4), pp 305-315. doi: 10.1007/s10456-010-9187-8. Retrieved from: http://www.escholarship.org/uc/item/7sc776rt
Angiogenesis

Resveratrol, a naturally occurring polyphenol, has been reported to be an anti-tumor and chemopreventive agent. Recent data show that it may also exert anti-angiogenic effects. We hypothesized that the anti-angiogenic activity of resveratrol may be c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19255a06b863dd4d4ceb16c90ff67953
http://www.escholarship.org/uc/item/4939p5cg

Anti-angiogenesis agents in metastatic or recurrent cervical cancer

Autor: Daniele A. Sumner, Lyndsay J. Willmott, Bradley J. Monk

Publikováno v: Gynecologic oncology. 116(2)

While the incidence of cervical cancer has declined significantly in the United States, it still remains a serious American health threat. When detected early, cervical cancer is generally curable. Early lesions are treated surgically, and locally ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5e1edf3fef262139e4ab8aa2e327e4
https://pubmed.ncbi.nlm.nih.gov/19861227

Catalysis of Strand Annealing by Replication Protein A Derives from Its Strand Melting Properties*

Autor: Marc S. Wold, Lyndsay J. Willmott, Robert A. Bambara, Jeremy D. Bartos, Sara K. Binz

Eukaryotic DNA-binding protein replication protein A (RPA) has a strand melting property that assists polymerases and helicases in resolving DNA secondary structures. Curiously, previous results suggested that human RPA (hRPA) promotes undesirable re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50948b8a019496cdbef4a9b80d0c3f47
https://europepmc.org/articles/PMC2490778/

Abstract 1399: The effect of radiation therapy with adjunctive oxaliplatin versus cisplatin chemotherapy in cervical cancer cell lines

Autor: Lyndsay J. Willmott, John P. Fruehauf, Bradley J. Monk, Muthana Al-Ghazi

Publikováno v: Cancer Research. 70:1399-1399

The current standard of care for locally advanced cervical cancer is radiation therapy (RT) with adjunctive cisplatin chemotherapy for radiation sensitization. Some patients are unable to tolerate cisplatin secondary to renal compromise and may be be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2071f4639e31faeb5ddc5b012fc6ec58
https://doi.org/10.1158/1538-7445.am10-1399