Výsledky vyhledávání

Comparison of Molecular Dynamics Averaged Structures for Complexes of Normal and Oncogenic ras-p21 with SOS Nucleotide Exchange Protein, Containing Computed Conformations for Three Crystallographically Undefined Domains, Suggests a Potential Role of These Domains in ras Signaling

Autor: Thomas M. Duncan, Fred K. Friedman, Matthew R. Pincus, Mark J. Hyde, James M. Chen, Lyndon Chie

Publikováno v: The Protein Journal. 23:217-228

ras-p21 protein binds to the son-of-sevenless (SOS) guanine nucleotide-exchange promoter that allows it to exchange GDP for GTP. Previously, we performed molecular dynamics calculations on oncogenic (Val 12-) and wild-type ras-p21 bound to SOS. By su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825ed2718d153123dba1ac7da96c413d
https://doi.org/10.1023/b:jopc.0000026417.72621.1f

Zobrazit plný text záznamu

Comparison of the Average Structures, from Molecular Dynamics, of Complexes of GTPase Activating Protein (GAP) with Oncogenic and Wild-Type ras-p21: Identification of Potential Effector Domains

Autor: Paul W. Brandt-Rauf, Fred K. Friedman, Lyndon Chie, James M. Chen, Matthew R. Pincus

Publikováno v: Journal of Protein Chemistry. 21:349-359

GTPase activating protein (GAP) is a known regulator of ras-p21 activity and is a likely target of ras-induced mitogenic signaling. The domains of GAP that may be involved in this signaling are unknown. In order to infer which domains of GAP may be i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be9527327362ed4e193627fc16f206a
https://doi.org/10.1023/a:1019994302273

Zobrazit plný text záznamu

Inhibition of ras-Induced Oocyte Maturation by Peptides from ras-p21 and GTPase Activating Protein (GAP) Identified as Being Effector Domains from Molecular Dynamics Calculations

Autor: Ziro Yamaizumi, Matthew R. Pincus, Paul W. Brandt-Rauf, Denise Chung, Fred K. Friedman, Lyndon Chie, Richard C. Robinson

Publikováno v: Journal of Protein Chemistry. 21:361-366

In the accompanying article, using molecular dynamics calculations, we found that the 66-77 and 122-138 domains in ras-p21 and the 821-827, 832-845, 917-924, 943-953, and 1003-1020 domains in GAP have different conformations in complexes of GAP with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7d80f007a3082f3211e96278ad7b30
https://doi.org/10.1023/a:1019946419111

Zobrazit plný text záznamu

Differences in Patterns of Activation of MAP Kinases Induced by Oncogenic ras–p21 and Insulin in Oocytes

Autor: Steven O. Smith, Richard C. Robinson, Matthew R. Pincus, Josef Michl, Fred K. Friedman, Masood Ranginwale, Paul W. Brandt-Rauf, Lyndon Chie, Ziro Yamaizumi, Mecheal Kanovsky, Denise Chung, Judy Flom

Publikováno v: Experimental Cell Research. 269:162-169

Oncogenic ras (Val 12-containing)–p21 protein induces oocyte maturation by a pathway that is blocked by peptides from effector domains of ras –p21, i.e., residues 35–47 (that block Val 12–p21-activated raf ) and 96–110 and 115–126, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c96bb29be4f65271a8d321756e29f80
https://doi.org/10.1006/excr.2001.5311

Zobrazit plný text záznamu

Induction of oocyte maturation by jun -N-terminal kinase (JNK) on the oncogenic ras -p21 pathway is dependent on the raf -MEK-MAP kinase signal transduction pathway

Autor: S. Amar, Josef Michl, Ziro Yamaizumi, Cecilia Kovac, M. C. M. Lin, Ze'ev Ronai, Victor Adler, Matthew R. Pincus, Fred K. Friedman, Denise L. Chung, H.-F. Kung, Lyndon Chie, Richard C. Robinson, H. Chen, Paul W. Brandt-Rauf

Publikováno v: Cancer Chemotherapy and Pharmacology. 45:441-449

Purpose: We have previously found that microinjection of activated MEK (mitogen activated kinase kinase) and ERK (mitogen-activated protein; MAP kinase) fails to induce oocyte maturation, but that maturation, induced by oncogenic ras-p21 and insulin-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fce60fea57f94046cdff10210b4471a
https://doi.org/10.1007/s002800051017

Zobrazit plný text záznamu

Identification of the Site of Inhibition of Oncogenic ras–p21-Induced Signal Transduction by a Peptide from a ras Effector Domain

Autor: Ziro Yamaizumi, James M. Chen, Josef Michl, Matthew R. Pincus, Denise L. Chung, Fred K. Friedman, Paul W. Brandt-Rauf, Shazia Amar, Lyndon Chie

Publikováno v: Journal of Protein Chemistry. 18:881-884

We have previously found that a peptide corresponding to residues 35-47 of the ras-p21 protein, from its switch 1 effector domain region, strongly inhibits oocyte maturation induced by oncogenic p21, but not by insulin-activated cellular wild-type p2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646f1a11c8b40b72175e02e4b8b60795
https://doi.org/10.1023/a:1020635414089

Zobrazit plný text záznamu

Specificity of inhibition of ras-p21 signal transduction by peptides from GTPase activating protein (GAP) and the son-of sevenless (SOS) ras-specific guanine nucleotide exchange protein

Autor: Lyndon Chie, Matthew R. Pincus, Denise Chung

Publikováno v: The protein journal. 24(4)

In previous studies, involving molecular modeling of wild-type and oncogenic forms of the ras-p21 protein bound to GTPase activating protein GAP and the ras-specific guanine nucleotide exchange-promoting protein, SOS, we identified specific domains o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa2d91252673d04bc925650c43b06b3
https://pubmed.ncbi.nlm.nih.gov/16283548

Zobrazit plný text záznamu

An effector peptide from glutathione-S-transferase-pi strongly and selectively blocks mitotic signaling by oncogenic ras-p21

Autor: Matthew R. Pincus, Lyndon Chie, Victor Adler, Denise Chung, Fred K. Friedman

Publikováno v: The protein journal. 23(3)

Oncogenic ras-p21 directly activates jun-N-terminal kinase (JNK) and its substrate, jun as a unique step on its mitogenic signal transduction pathway. This activation is blocked by the specific JNK-jun inhibitor, glutathione-S-transferase-pi (GST-pi)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2435e0a9f14f4c3f84b741658a7b2d6e
https://pubmed.ncbi.nlm.nih.gov/15200055

Zobrazit plný text záznamu

Loop domain peptides from the SOS ras-guanine nucleotide exchange protein, identified from molecular dynamics calculations, strongly inhibit ras signaling

Autor: James M. Chen, Fred K. Friedman, Matthew R. Pincus, Lyndon Chie, Thomas M. Duncan, Denise Chung

Publikováno v: The protein journal. 23(3)

In the accompanying paper, we found, using molecular dynamics calculations, four domains of the ras-specific SOS guanine nucleotide exchange protein (residues 589-601, 654-675, 746-761, and 980-989) that differ markedly in conformation when SOS is co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b030fb820043d34728635ea6c9fcbbf
https://pubmed.ncbi.nlm.nih.gov/15200054

Zobrazit plný text záznamu

A protein methyl transferase, PRMT5, selectively blocks oncogenic ras-p21 mitogenic signal transduction

Autor: Lyndon, Chie, Jeffry R, Cook, Denise, Chung, Ralf, Hoffmann, Zhihong, Yang, Youngsun, Kim, Sidney, Pestka, Matthew R, Pincus

Publikováno v: Annals of clinical and laboratory science. 33(2)

A Janus-2 (JAK-2) binding protein, JBP1, has been found to function as an arginine methyl transferase and is now designated PRMT5. Co-injection of plasmids encoding this protein together with oncogenic (Val 12-containing) ras-p21 protein into Xenopus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fb83d5bb2bcee0784573f6673d95dbf8
https://pubmed.ncbi.nlm.nih.gov/12817625

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání