Výsledky vyhledávání - "Lynda T. Lucas"

Characterization of DNA Damage at Purine Residues in Oligonucleotides and Calf Thymus DNA Induced by the Mutagen 1-Nitrosoindole-3-acetonitrile

Autor: Lynda T. Lucas, George D. D. Jones, David Gatehouse, David E. G. Shuker

Publikováno v: Chemical Research in Toxicology. 14:158-164

N-Nitrosoindoles can efficiently transfer the nitroso group to nucleophilic targets in isolated purine nucleotides, causing depurination, deamination, and the formation of a novel guanine analogue, oxanine [Lucas, L. T., Gatehouse, D., and Shuker, D.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f064b45ee6f3601d8a023cd86cd9f829
https://doi.org/10.1021/tx000179r

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Efficient Nitroso Group Transfer fromN-Nitrosoindoles to Nucleotides and 2′-Deoxyguanosine at Physiological pH

Autor: David E. G. Shuker, D.G. Gatehouse, Lynda T. Lucas

Publikováno v: Journal of Biological Chemistry. 274:18319-18326

The endogenous formation of N-nitrosoindoles is of concern since humans are exposed to a variety of naturally occurring and synthetic indolic compounds. As part of a study to evaluate the genotoxicity of N-nitrosoindoles, the reactions of three model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::884185369782780aaac6240cf29fe8d8
https://doi.org/10.1074/jbc.274.26.18319

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