Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Lynda S. Ostedgaard"'
Publikováno v:
Journal of Cystic Fibrosis. 22:S23-S26
Cystic fibrosis (CF), an autosomal genetic disorder caused by the dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, is characterized by mucus accumulation in the lungs, the intestinal tract, and the pancreatic duc
Autor:
Lynda S Ostedgaard, Margaret P Price, Kristin M Whitworth, Mahmoud H Abou Alaiwa, Anthony J Fischer, Akshaya Warrier, Melissa Samuel, Lee D Spate, Patrick D Allen, Brieanna M Hilkin, Guillermo S Romano Ibarra, Miguel E Ortiz Bezara, Brian J Goodell, Steven E Mather, Linda S Powers, Mallory R Stroik, Nicholas D Gansemer, Camilla E Hippee, Keyan Zarei, J Adam Goeken, Thomas R Businga, Eric A Hoffman, David K Meyerholz, Randall S Prather, David A Stoltz, Michael J Welsh
Publikováno v:
eLife, Vol 9 (2020)
Submucosal glands (SMGs) are a prominent structure that lines human cartilaginous airways. Although it has been assumed that SMGs contribute to respiratory defense, that hypothesis has gone without a direct test. Therefore, we studied pigs, which hav
Externí odkaz:
https://doaj.org/article/de4e52b4b350483bb95240e3006ac61e
Autor:
Sebastian Kirchner, Zhiwei Cai, Robert Rauscher, Nicolai Kastelic, Melanie Anding, Andreas Czech, Bertrand Kleizen, Lynda S Ostedgaard, Ineke Braakman, David N Sheppard, Zoya Ignatova
Publikováno v:
PLoS Biology, Vol 15, Iss 5, p e2000779 (2017)
Synonymous single nucleotide polymorphisms (sSNPs) are considered neutral for protein function, as by definition they exchange only codons, not amino acids. We identified an sSNP that modifies the local translation speed of the cystic fibrosis transm
Externí odkaz:
https://doaj.org/article/89ad557e9e7d489bb7580184eb1c0d23
Autor:
Eric A. Hoffman, Randall S. Prather, Thomas R. Businga, Margaret P. Price, Lynda S. Ostedgaard, Guillermo S Romano Ibarra, Brian J Goodell, Patrick D Allen, Mallory R. Stroik, Melissa Samuel, Miguel E Ortiz Bezara, David K. Meyerholz, Camilla E Hippee, Steven E Mather, Linda S. Powers, Michael J. Welsh, Lee D. Spate, Nicholas D. Gansemer, Mahmoud H. Abou Alaiwa, Brieanna M Hilkin, Akshaya Warrier, Kristin M. Whitworth, David A. Stoltz, J. Adam Goeken, Anthony J. Fischer, Keyan Zarei
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Submucosal glands (SMGs) are a prominent structure that lines human cartilaginous airways. Although it has been assumed that SMGs contribute to respiratory defense, that hypothesis has gone without a direct test. Therefore, we studied pigs, which hav
Autor:
Akshaya Warrier, Lynda S. Ostedgaard, Michael J. Welsh, Randall S. Prather, Thomas R. Businga, Margaret P. Price, Brieanna M Hilkin, Lee D. Spate, Miguel E Ortiz Bezara, Camilla E Hippee, Guillermo S Romano Ibarra, Keyan Zarei, Patrick D Allen, Steven E Mather, J. Adam Goeken, Mahmoud H. Abou Alaiwa, Linda S. Powers, Anthony J. Fischer, Kristin M. Whitworth, David A. Stoltz, Melissa Samuel, David K. Meyerholz, Mallory R. Stroik, Eric A. Hoffman, Nicholas D. Gansemer, Brian J Goodell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a86286ac82a3812b35bfef1950a736ec
https://doi.org/10.7554/elife.59653.sa2
https://doi.org/10.7554/elife.59653.sa2
Autor:
Laura I. Marquez Loza, Brajesh K. Singh, Linda S. Powers, Ian M. Thornell, Ashley L. Cooney, Camilla E Hippee, Chris Wohlford-Lenane, David A. Stoltz, Lynda S. Ostedgaard, Paul B. McCray, Patrick L. Sinn, David K. Meyerholz
Publikováno v:
Nucleic Acids Research
Cystic fibrosis (CF) is a common genetic disease caused by mutations in the gene coding for cystic fibrosis transmembrane conductance regulator (CFTR). Although CF affects multiple organ systems, chronic bacterial infections and inflammation in the l
Autor:
Ian M. Thornell, C. Cano Portillo, P. Allen, E. Stapleton, J. Ash, A. Comellas, Alejandro A. Pezzulo, Lynda S. Ostedgaard, W. Yu, Michael J. Welsh, Steven E Mather, David A. Stoltz, Joseph Zabner, David K. Meyerholz
Publikováno v:
Journal of Cystic Fibrosis. 20:S322
Autor:
Drake C. Bouzek, Mahmoud H. Abou Alaiwa, Daniel P. Cook, Connor P. Parker, David K. Meyerholz, Linda S. Powers, Nicholas M. Sawin, Nicholas D. Gansemer, David A. Stoltz, Ian M. Thornell, Thomas O. Moninger, Michael J. Welsh, Lynda S. Ostedgaard, James D. McMenimen
Publikováno v:
Proceedings of the National Academy of Sciences. 114:6842-6847
Gel-forming mucins, the primary macromolecular components of airway mucus, facilitate airway clearance by mucociliary transport. In cystic fibrosis (CF) altered mucus properties impair mucociliary transport. Airways primarily secrete two closely rela
Autor:
Eric A. Hoffman, Lynda S. Ostedgaard, Anthony J. Fischer, Michael J. Welsh, Keyan Zarei, David A. Stoltz, Brieanna M Hilkin, Maria I Pino-Argumedo, Anna L Chaly, Mahmoud H. Abou Alaiwa, Nicholas D. Gansemer, Cullen R Shanrock, Patrick D Allen
Publikováno v:
JCI Insight. 4
Mucus produced by submucosal glands is a key component of respiratory mucociliary transport (MCT). When it emerges from submucosal gland ducts, mucus forms long strands on the airway surface. However, the function of those strands is uncertain. To te
Autor:
Viral Shah, Michael J. Welsh, Lynda S. Ostedgaard, Philip H. Karp, Xiao Xiao Tang, Sarah E. Ernst, Connor P. Parker
Publikováno v:
Proceedings of the National Academy of Sciences. 113:5382-5387
Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. Airway disease is the major source of morbidity and mortality. Successful implementation of gene- and cell-