Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lynda Rocheleau"'
Publikováno v:
npj Microgravity, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Space anemia affects astronauts and the underlying molecular alterations remain unknown. We evaluated the response of erythropoiesis-modulating genes to spaceflight through the analysis of leukocyte transcriptomes from astronauts during long
Externí odkaz:
https://doaj.org/article/4b24bee001b44efebaac65f633e9aa0d
Autor:
Erin Collins, Yannick Galipeau, Corey Arnold, Anne Bhéreur, Ronald Booth, Arianne C. Buchan, Curtis Cooper, Angela M. Crawley, Pauline S. McCluskie, Michaeline McGuinty, Martin Pelchat, Lynda Rocheleau, Raphael Saginur, Chris Gravel, Steven Hawken, Marc-André Langlois, Julian Little
Publikováno v:
Frontiers in Public Health, Vol 12 (2024)
IntroductionMore than 3 years into the pandemic, there is persisting uncertainty as to the etiology, biomarkers, and risk factors of Post COVID-19 Condition (PCC). Serological research data remain a largely untapped resource. Few studies have investi
Externí odkaz:
https://doaj.org/article/03769940dcf7465a9cf8e66c1dcde6b6
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSpaceflight leads to the deconditioning of multiple body systems including the immune system. We sought to characterize the molecular response involved by capturing changes in leukocyte transcriptomes from astronauts transitioning to and
Externí odkaz:
https://doaj.org/article/7e56d9623091412c9d3d97c9cda0a939
Autor:
Karen Colwill, Yannick Galipeau, Matthew Stuible, Christian Gervais, Corey Arnold, Bhavisha Rathod, Kento T Abe, Jenny H Wang, Adrian Pasculescu, Mariam Maltseva, Lynda Rocheleau, Martin Pelchat, Mahya Fazel‐Zarandi, Mariam Iskilova, Miriam Barrios‐Rodiles, Linda Bennett, Kevin Yau, François Cholette, Christine Mesa, Angel X Li, Aimee Paterson, Michelle A Hladunewich, Pamela J Goodwin, Jeffrey L Wrana, Steven J Drews, Samira Mubareka, Allison J McGeer, John Kim, Marc‐André Langlois, Anne‐Claude Gingras, Yves Durocher
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 3, Pp n/a-n/a (2022)
Abstract Objectives Antibody testing against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has been instrumental in detecting previous exposures and analyzing vaccine‐elicited immune responses. Here, we describe a scalable soluti
Externí odkaz:
https://doaj.org/article/5e0ee81ad5a14b2c90b3b4fd0393afdc
Autor:
Lynda Rocheleau, Geneviève Laroche, Kathy Fu, Corina M. Stewart, Abdulhamid O. Mohamud, Marceline Côté, Patrick M. Giguère, Marc-André Langlois, Martin Pelchat
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
The mutation rate and evolution of RNA viruses correlate with viral adaptation. While most mutations do not make significant contributions to viral molecular evolution, some are naturally selected and produce variants through positive selection.
Externí odkaz:
https://doaj.org/article/6f1b37cfcbb44773b661ca22b1ff59b2
Autor:
Emma Bondy-Chorney, Tara E Crawford Parks, Aymeric Ravel-Chapuis, Roscoe Klinck, Lynda Rocheleau, Martin Pelchat, Benoit Chabot, Bernard J Jasmin, Jocelyn Côté
Publikováno v:
PLoS Genetics, Vol 12, Iss 1, p e1005827 (2016)
Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder caused by an expansion of CUG repeats in the 3' UTR of the DMPK gene. The CUG repeats form aggregates of mutant mRNA, which cause misregulation and/or sequestration of RNA-binding proteins,
Externí odkaz:
https://doaj.org/article/2966a5007cfc488791adce420a91f35a
Publikováno v:
Medicine and science in sports and exercise.
We sought to isolate the microgravity effect of spaceflight from other space stressors by characterizing the leukocytes' transcriptome of participants to a 60-day bed rest study; an Earth model of microgravity.Twenty healthy men received a nutritiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f9c360ce3bc5585f494393409ce397
https://pubmed.ncbi.nlm.nih.gov/36251376
https://pubmed.ncbi.nlm.nih.gov/36251376
Autor:
Bhavisha Rathod, Matthew Stuible, Christine Mesa, Steven J. Drews, Angel Xinliu Li, Marc-André Langlois, Mariam Maltseva, Adrian Pasculescu, Mahya Fazel-Zarandi, Christian Gervais, Karen Colwill, François Cholette, Corey Arnold, Yannick Galipeau, Pamela J. Goodwin, Anne-Claude Gingras, Jeffrey L. Wrana, Lynda Rocheleau, Linda Bennett, Jenny Wang, Miriam Barrios-Rodiles, Mariam Iskilova, Kento T. Abe, Samira Mubareka, John Kim, Michelle A. Hladunewich, Kevin Yau, Yves Durocher, Martin Pelchat, Allison McGeer, Aimee Paterson
BACKGROUND: Testing for antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been instrumental in detecting previous exposures and analyzing vaccine-elicited immune responses. Here, we describe a scalable "Made-in-Canad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f78af31ad2a992a3df7d69ae56c14be
https://doi.org/10.1101/2021.10.25.21265476
https://doi.org/10.1101/2021.10.25.21265476
Publikováno v:
Virology. 536:91-100
Initiation of influenza A virus (IAV) transcription depends on RNA primers derived from host RNAs. During this process, some primers are elongated by a few nucleotides, realigned on the viral RNA templates (vRNA), and then used to initiate another ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c65ec29f5259393d8bdc6595ddae176
https://doi.org/10.1016/j.virol.2019.08.002
https://doi.org/10.1016/j.virol.2019.08.002
Publikováno v:
Disability and rehabilitation. 44(14)
The objective of this study is to explore the transcriptomic and biologic variables characterizing the longitudinal rehabilitation intervention of patients with hospital-acquired deconditioning (HAD).This prospective clinical trial recruited HAD pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4948161869ac6b0a19896be1e287189
https://pubmed.ncbi.nlm.nih.gov/33478276
https://pubmed.ncbi.nlm.nih.gov/33478276