Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lynda M. Evans"'
Autor:
Lynda M. Evans, Robert W. Hardy
Publikováno v:
The Open Breast Cancer Journal. 4:108-122
For over 70 years, long chain fatty acids have been implicated in the development and progression of breast cancer. Although the exact role remains to be elucidated, dietary factors have been implicated in approximately 35% of cancer deaths. Currentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38a0dc18b3bb4cf1228c529e196eb6d5
https://doi.org/10.2174/1876817201002010108
https://doi.org/10.2174/1876817201002010108
Publikováno v:
Nutrition and Cancer. 61:746-753
Stearic acid (stearate) is an 18-carbon saturated fatty acid that has been shown to inhibit invasion and proliferation and induce apoptosis in various human cell types. The specificity of stearate-induced apoptosis for cancerous versus noncancerous b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b58dc6407e8fe7283265537a6afbdf6
https://doi.org/10.1080/01635580902825597
https://doi.org/10.1080/01635580902825597
Autor:
Lynda M. Evans, Tomasz Mandat, Renata Duchnowska, Diane Palmieri, Ewa Szutowicz-Zielińska, Patricia S. Steeg, Waldemar Och, Stephan Woditschka, Sunil Badve, Bogumiła Czartoryska-Arłukowicz, Natasha M. Flores, Mirit I. Aladjem, James B. Mitchell, Jacek Jassem, Tomasz Trojanowski, George W. Sledge, L. Tiffany Reed, Brunilde Gril, Yesim Gökmen-Polar, Wojciech Biernat, Yongzhen Qian, Haiqing Fu
Publikováno v:
Journal of the National Cancer Institute. 106(7)
Breast cancer frequently metastasizes to the brain, colonizing a neuro-inflammatory microenvironment. The molecular pathways facilitating this colonization remain poorly understood.Expression profiling of 23 matched sets of human resected brain metas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8a7ed688846be26496646470ac2c22
https://pubmed.ncbi.nlm.nih.gov/24948741
https://pubmed.ncbi.nlm.nih.gov/24948741
Publikováno v:
Central Nervous System Metastasis, the Biological Basis and Clinical Considerations ISBN: 9789400752900
An understanding of the molecular biology of brain metastasis development is critical to the development of new preventatives and therapeutics. Our current understanding is largely based on functional validation studies of candidate genes in animal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af0e349bdefff476a8a87922f006d0a8
https://doi.org/10.1007/978-94-007-5291-7_2
https://doi.org/10.1007/978-94-007-5291-7_2
Autor:
Arig Ibrahim-Hashim, Robert W. Hardy, Chuanyu Li, Lynda M. Evans, Gene P. Siegal, Renee A. Desmond, Eric C. Toline, Xiangmin Zhao
Previous studies have shown that stearate (C18:0), a dietary long-chain saturated fatty acid, inhibits breast cancer cell neoplastic progression; however, little is known about the mechanism modulating these processes. We demonstrate that stearate, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc82f9d2ad04525ca675e742647539d
https://europepmc.org/articles/PMC3149204/
https://europepmc.org/articles/PMC3149204/
Autor:
Robert W. Hardy, Renee A. Desmond, Eric C. Toline, Lynda M. Evans, Arig Ibrahim Hashim, Gene P. Siegal
Publikováno v:
Clinicalexperimental metastasis. 26(5)
Stearate is an 18-carbon saturated fatty acid found in many foods in the western diet, including beef and chocolate. Stearate has been shown to have anti-cancer properties during early stages of neoplastic progression. However, previous studies have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd83996deca9806cf3e5dec420cff74a
https://pubmed.ncbi.nlm.nih.gov/19267249
https://pubmed.ncbi.nlm.nih.gov/19267249
Autor:
John C. Kappes, Hyunki Kim, Gene P. Siegal, Lynda M. Evans, Robert W. Hardy, Renee A. Desmond, April Adams Szafran, Stephanie Cowey, Kurt R. Zinn
Publikováno v:
Clinicalexperimental metastasis. 24(5)
This study sought to determine if weekly X-ray exposure affected breast cancer cell metastasis to bone and to also evaluate the use of bioluminescent imaging (BLI) and microSPECT for detection of metastatic bone lesions. Five week old nude mice were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b36f0f3d43d04d006a5fc0e7fa58ff30
https://pubmed.ncbi.nlm.nih.gov/17541709
https://pubmed.ncbi.nlm.nih.gov/17541709
Autor:
Patricia S. Steeg, George W. Sledge, Diane Palmieri, Lynda M. Evans, Daniel P. Fitzgerald, Sunil Badve, Stephan Woditschka
Publikováno v:
Cancer Research. 71:2667-2667
To investigate the molecular mechanisms responsible for breast cancer metastasis to the brain, a gene expression analysis was performed using formalin-fixed, paraffin embedded sections of matched primary breast tumors and resected brain metastases. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf1752a93debbb18eb467a4421aca77b
https://doi.org/10.1158/1538-7445.am2011-2667
https://doi.org/10.1158/1538-7445.am2011-2667
Autor:
Robert W. Hardy, Renee A. Desmond, Eric C. Toline, Lynda M. Evans, Siegal P. Gene, Ming-Che T. Shen
Publikováno v:
Cancer Research. 70:1885-1885
Stearate is a dietary, long-chain saturated fatty acid (C18:0) that has been shown to decrease breast cancer cell proliferation, migration, and invasion in vitro and reduce tumor growth and metastasis in vivo. Obesity, or excess adipose tissue, is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff02e091b495472a84831df3bdbeede6
https://doi.org/10.1158/1538-7445.am10-1885
https://doi.org/10.1158/1538-7445.am10-1885
Autor:
Gene P. Siegal, Renee A. Desmond, Eric C. Toline, Robert W. Hardy, Lynda M. Evans, Arig Ibrahim-Hashim
Publikováno v:
Cancer Research. 70:2878-2878
The goal of the present study was to test the effectiveness of dietary stearate at inhibiting breast cancer development in a carcinogen induced breast cancer model. Three diets were used; a 17% stearate diet, the key being that highly purified steara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ffecab7992ad0223d6fd132b2233ac6
https://doi.org/10.1158/1538-7445.am10-2878
https://doi.org/10.1158/1538-7445.am10-2878