Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Lynda Little-Ihrig"'
Autor:
Qin Zhu, Lynda Little-Ihrig, Nishi Yadav, Joseph Latoche, Kathryn Day, Scott Mason, Charles Laymon, Sina Tavakoli, Carolyn Anderson, Enrico Novelli
Publikováno v:
HemaSphere, Vol 7, p e58374e6 (2023)
Externí odkaz:
https://doaj.org/article/26c385ba42e84a5c9da8fe53c5a52686
Autor:
Rimi Hazra, Holland Hubert, Lynda Little-Ihrig, Samit Ghosh, Solomon Ofori-Acquah, Xiaoming Hu, Enrico M Novelli
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 692 (2023)
Occlusion of cerebral blood vessels causes acute cerebral hypoxia—an important trigger of ischemic white matter injury and stroke in sickle cell disease (SCD). While chronic hypoxia triggers compensatory neuroprotection via insulin-like growth fact
Externí odkaz:
https://doaj.org/article/ecc40c6704b24073a57dc132f79ffa4c
Autor:
Rimi Hazra, Hongjian Pu, Lesley M Foley, Lynda Little-Ihrig, T Kevin Hitchens, Samit Ghosh, Solomon F Ofori-Acquah, Xiaoming Hu, Enrico M Novelli
Publikováno v:
PNAS Nexus. 2
White-matter injury in sickle-cell disease (SCD) includes silent cerebral infarction diagnosed by diffusion tensor imaging (DTI), a complication associated with cognitive dysfunction in children with SCD. The link between white-matter injury and cogn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5360e0d101bd78e7b527d40292bb13b
https://doi.org/10.1093/pnasnexus/pgad149
https://doi.org/10.1093/pnasnexus/pgad149
Autor:
Rimi Hazra, Hongjan Pu, Lesley M. Foley, T. Kevin Hitchens, Lynda Little-Ihrig, Samit Ghosh, Solomon Fiifi Ofori-Acquah, Xiaoming Hu, Enrico M. Novelli
Publikováno v:
Blood. 140:441-442
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a33aa12dd1d3da860c694c5eb9ef0792
https://doi.org/10.1182/blood-2022-169094
https://doi.org/10.1182/blood-2022-169094
Publikováno v:
Blood. 140:8233-8234
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6571debbbfbec37f6e5452e6ab3c5f9a
https://doi.org/10.1182/blood-2022-165434
https://doi.org/10.1182/blood-2022-165434
Autor:
Lynda Little-Ihrig, Sina Tavakoli, Joseph D. Latoche, Carolyn J. Anderson, Lydia A. Perkins, Qin Zhu, Kathryn Day, Lea Nyiranshuti, Prithu Sundd, Enrico M. Novelli
Publikováno v:
Blood Adv
In sickle cell disease (SCD), very late antigen-4 (VLA-4 or integrin α4β1) mediates the adhesion of reticulocytes to inflamed, proinflammatory endothelium, a key process in promoting vaso-occlusive episodes (VOEs). We hypothesized that a radionucli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe851667ddcf1caee0c3865d4ad94a4
https://doi.org/10.1182/bloodadvances.2020002642
https://doi.org/10.1182/bloodadvances.2020002642
Autor:
Mark T. Gladwin, Natasha M. Rogers, Lynda Little-Ihrig, Daniel N. Meijles, Evan DeVallance, George Miles, Mingyi Yao, Mark A. Ross, Jeffrey J. Baust, Karin P. Potoka, Patrick J. Pagano, Claudette M. St. Croix, Heather E. Knupp, Jeffrey S. Isenberg, Enrico M. Novelli
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Pulmonary hypertension (PH) is a leading cause of death in sickle cell disease (SCD) patients. Hemolysis and oxidative stress contribute to SCD-associated PH. We have reported that the protein thrombospondin-1 (TSP1) is elevated in the plasma of pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426cf5fb65c826543224f249e7695d76
https://pubmed.ncbi.nlm.nih.gov/30892078
https://pubmed.ncbi.nlm.nih.gov/30892078
Autor:
Charles M. Laymon, Sina Tavakoli, Mark T. Gladwin, Carolyn J. Anderson, N. Scott Mason, Xiaoyuan Chen, Lynda Little-Ihrig, Chan Hong Moon, Lydia A. Perkins, Lixin Lang, Enrico M. Novelli, Tiffany A. Pham
Publikováno v:
BJR | case reports
Increased vascular cell adhesion (hyperadhesion) to the endothelium is responsible for the hallmark acute pain episodes, or vaso-occlusive crises (VOC), of sickle cell disease. The integrin αvβ3 plays an important role in VOC since it mediates sick
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857f57d33369a892504cdd5e36cb4b43
https://doi.org/10.1259/bjrcr.20200024
https://doi.org/10.1259/bjrcr.20200024
Autor:
Uma R. Chandran, Lynda Little-Ihrig, Mary Hunzicker-Dunn, Anthony J. Zeleznik, Pawan Puri, Nathan C. Law
Publikováno v:
Scientific Reports
Activation of protein kinase A (PKA) by follicle stimulating hormone (FSH) transduces the signal that drives differentiation of ovarian granulosa cells (GCs). An unresolved question is whether PKA is sufficient to initiate the complex program of GC r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d86376f176ffbc6bb29ce20c827fb0b
Autor:
Uma R. Chandran, Rosalba Escamilla-Hernandez, Kyle E. Orwig, Lynda Little-Ihrig, Anthony J. Zeleznik, Junming Yue
Publikováno v:
Molecular Endocrinology. 22:1842-1852
Activation of the protein kinase A (PKA) signaling system is necessary for FSH-induced granulosa cell differentiation, but it is not known whether activation of PKA is sufficient to account for the complex pattern of gene expression that occurs durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8afac8bed1a4ec8832f4f770da8d6fa0
https://doi.org/10.1210/me.2008-0103
https://doi.org/10.1210/me.2008-0103