Výsledky vyhledávání - "Lynda L. Miller"

Akademický článek

Synergy Between Proline-Rich Antimicrobial Peptides and Small Molecule Antibiotics Against Selected Gram-Negative Pathogens in vitro and in vivo

Autor: Laszlo Otvos Jr., Eszter Ostorhazi, Dora Szabo, Steven D. Zumbrun, Lynda L. Miller, Stephanie A. Halasohoris, Puvi D. Desai, Sharon M. Int Veldt, Carl N. Kraus

Publikováno v: Frontiers in Chemistry, Vol 6 (2018)

As monotherapy, modified proline-rich antimicrobial peptides (PrAMPs) protect animals from experimental bacteremia in a dose-dependent manner. We evaluated the in vitro synergy of a modified PrAMP, A3-APO, a dimer, previously shown to inhibit the 70

Externí odkaz: https://doaj.org/article/f79604ed68b04feeb322f7ee2debeb9b

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In Vivo Activity of Repurposed Amodiaquine as a Host-Targeting Therapy for the Treatment of Anthrax

Publikováno v: ACS Infect Dis

[Image: see text] Anthrax is caused by Bacillus anthracis and can result in nearly 100% mortality due in part to anthrax toxin. Antimalarial amodiaquine (AQ) acts as a host-oriented inhibitor of anthrax toxin endocytosis. Here, we determined the phar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df80135ee02f50492e189d514256fed9
https://doi.org/10.1021/acsinfecdis.1c00190

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Demonstration of the Broad-Spectrum In Vitro Activity of Finafloxacin against Pathogens of Biodefense Interest

Autor: Sarah V. Harding, Stephanie A. Halasohoris, Purvi D. Desai, Steven D. Zumbrun, Lynda L. Miller, Mark I. Richards, P. Russell, Christine Bentley, Kay B. Barnes

Publikováno v: Antimicrobial Agents and Chemotherapy. 63

This study investigated the in vitro activity of finafloxacin against panels of the biodefence pathogens. Broth microdilution assays were performed at neutral and acidic pH, to determine the effectiveness of the antibiotics in conditions typical of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::277543337b452fb1dde65cecb5ae1aff
https://doi.org/10.1128/aac.01470-19

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Demonstration of the broad spectrum

Autor: Kay B, Barnes, Steven D, Zumbrun, Stephanie A, Halasohoris, Purvi D, Desai, Lynda L, Miller, Mark I, Richards, Paul, Russell, Christine, Bentley, Sarah V, Harding

Publikováno v: Antimicrobial Agents and Chemotherapy

This study investigated the in vitro activity of finafloxacin against bacterial strain panels of the biodefense pathogens. Broth microdilution assays were performed at neutral and acidic pH to determine the effectiveness of the antibiotics under cond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::48147b28d74a194da149c6b3df8b9858
https://pubmed.ncbi.nlm.nih.gov/31570393

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D-cycloserine or similar physiochemical compounds may be uniquely suited for use inBacillus anthracisspore decontamination strategies

Autor: Christopher K. Cote, Christopher P. Klimko, S.A. Halasahoris, T.O. Omotade, C.L. Marchand, Susan L. Welkos, Lynda L. Miller, Joel A. Bozue, Jared D. Heffron

Publikováno v: Journal of Applied Microbiology. 115:1343-1356

Aims As observed in the aftermath of the anthrax attacks of 2001, decontamination and remediation of a site contaminated by the accidental or intentional release of Bacillus anthracis spores is difficult, costly and potentially damaging to the enviro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1819d8850934cc78a685bc2e2e926cd
https://doi.org/10.1111/jam.12322

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Pharmacokinetic-Pharmacodynamic Assessment of Faropenem in a Lethal Murine Bacillus anthracis Inhalation Postexposure Prophylaxis Model

Autor: Nebojsa Janjic, Lynda L. Miller, Ian A. Critchley, Jinfang Li, Amber A. Beaudry, Christopher M. Rubino, Sujata M. Bhavnani, Paul G. Ambrose, Stanley C. Gill, Jennifer Bassett, Kimberly Clawson Stone, Henry S. Heine

Publikováno v: Antimicrobial Agents and Chemotherapy. 54:1678-1683

There are few options for prophylaxis after exposure to Bacillus anthracis , especially in children and women of childbearing potential. Faropenem is a β-lactam in the penem subclass that is being developed as an oral prodrug, faropenem medoxomil, f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1532d784085fa12c5748a18c1fd48b
https://doi.org/10.1128/aac.00737-08

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Activity of Dalbavancin against Bacillus anthracis In Vitro and in a Mouse Inhalation Anthrax Model

Autor: Henry S. Heine, Lynda L. Miller, Jennifer Bassett, Beth P. Goldstein, Bret K. Purcell

Publikováno v: Antimicrobial Agents and Chemotherapy. 54:991-996

Bacillus anthracis , the causative agent of anthrax, can produce fatal disease when it is inhaled or ingested by humans. Dalbavancin, a novel, semisynthetic lipoglycopeptide, has potent activity, greater than that of vancomycin, against Gram-positive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f07577b1230b85a19bd169e697d1b9
https://doi.org/10.1128/aac.00820-09

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Efficacy of Oritavancin in a Murine Model of Bacillus anthracis Spore Inhalation Anthrax

Autor: Gregory Moeck, Jennifer Bassett, Dario Lehoux, Francis F. Arhin, Lynda L. Miller, Thomas R. Parr, Bruce E. Ivins, A. Bassett, Henry S. Heine

Publikováno v: Antimicrobial Agents and Chemotherapy. 52:3350-3357

Bacillus anthracis, a gram-positive, spore-forming rod and the causative agent of anthrax, primarily causes disease in animals. In humans, it can produce a fatal disease if the spores are inhaled or ingested. The Centers for Disease Control and Preve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2192874b91a9bae4322c28fc7db3bec4
https://doi.org/10.1128/aac.00360-08

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