Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lynda K. Hawkins"'
Autor:
Pamela S Shirley, Cheng Cheng, Michele Kaloss, David A. Stewart, Paul L. Hallenbeck, Lynda K. Hawkins, Suzanne Forry-Schaudies, Carl M. Hay, P. Seshidhar Reddy, Anthony Marinov, John L. Jakubczak, Ying Huang, Patricia Ryan, Jingping Yang, Yelena Skripchenko, Lori Clarke, Ling Xu, Sandrina Phipps, Shanthi Ganesh
Publikováno v:
Cancer Gene Therapy. 11:555-569
A potentially promising treatment of metastatic cancer is the systemic delivery of oncolytic adenoviruses. This requires engineering viruses which selectively replicate in tumors. We have constructed such an oncolytic adenovirus, OAS403, in which two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ccf2b27147f8d0846314d8ea8c23ab
https://doi.org/10.1038/sj.cgt.7700735
https://doi.org/10.1038/sj.cgt.7700735
Autor:
Adam Sampson-Johannes, Ali Fattaey, Allan Balmain, Jenny Holt, Vivian Lee, Thomas Dubensky, Galila Kitzes, Wen Yan, Yuqiao Shen, Terry Hermiston, Josh Watanabe, Farid Dormishian, Lynda K Hawkins
Publikováno v:
Journal of Virology. 77:2640-2650
Mutants of human adenovirus 5 (Ad5) with enhanced oncolytic activity were isolated by using a procedure termed bioselection. Two mutants, ONYX-201 and ONYX-203, were plaque purified from a pool of randomly mutagenized Ad5 that was repeatedly passaged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408152259b46ad3fe976b491e39fd543
https://doi.org/10.1128/jvi.77.4.2640-2650.2003
https://doi.org/10.1128/jvi.77.4.2640-2650.2003
Autor:
Terry Hermiston, Lynda K Hawkins
Publikováno v:
Gene Therapy. 8:1132-1141
Genetically modified replication-selective human adenoviruses are currently undergoing testing in the clinical setting as anticancer agents. Coupling the lytic function of these viruses with virus-mediated transgene delivery represents a powerful ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa8ddf4c40154b80128407f8d3ecfbd
https://doi.org/10.1038/sj.gt.3301508
https://doi.org/10.1038/sj.gt.3301508
Autor:
Lynda K Hawkins, Leisa Johnson, D. Castro, Jenny Holt, Maxine Bauzon, Julie Nye, P. Trown, Terry Hermiston, M. D. Young, Galila Kitzes
Publikováno v:
Gene Therapy. 8:1123-1131
The use of genetically engineered, replication-selective viruses to treat cancer is being realized with viruses such as ONYX-015, a human adenovirus that selectively destroys p53 mutant cancer cells. To enhance further the clinical efficacy of ONYX-0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8333c8668888d88b425419afb070d65
https://doi.org/10.1038/sj.gt.3301507
https://doi.org/10.1038/sj.gt.3301507
Publikováno v:
Scopus-Elsevier
There is an open reading frame in the E3 transcription unit of adenovirus type 3 (Ad3) and Ad7 that could encode a protein of 16 kDa (16K protein). Ad3 and Ad7 are members of subgroup B of human adenoviruses. Using a rabbit antipeptide antiserum, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39ca215e86ad1bc4ddf0df4fbfb7dac
https://doi.org/10.1128/jvi.69.7.4292-4298.1995
https://doi.org/10.1128/jvi.69.7.4292-4298.1995
Autor:
William S. M. Wold, Lynda K. Hawkins
Publikováno v:
Virology. 188:486-494
There is an open reading frame between ATG 291 and TGA 612 in the early region E3 transcription unit of adenovirus 2 (Ad2) that could encode a protein of 12,500 MW (12.5K). To address whether this protein is synthesized, we generated an antiserum aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6add1d289849172c8856120e65171356
https://doi.org/10.1016/0042-6822(92)90502-g
https://doi.org/10.1016/0042-6822(92)90502-g
One of the most time-consuming steps in the generation of adenoviral vectors is the construction of recombinant plasmids. This chapter describes a detailed method for the rapid construction of adenoviral vectors. The method described here uses homolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aca92ec2fea9a2ac919268fbfdb5e2bf
https://doi.org/10.1385/1-59745-166-5:61
https://doi.org/10.1385/1-59745-166-5:61
Publikováno v:
Oncogene. 24(52)
Changes initiated at the cellular and systemic levels as a result of viral infection or neoplastic transformation share significant overlap. Therefore, the use of replicating viruses to treat tumors has long been postulated as a promising avenue for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f1f757e3515e6839d4f6aafac52d10
https://pubmed.ncbi.nlm.nih.gov/16299536
https://pubmed.ncbi.nlm.nih.gov/16299536
Autor:
Janet L. Martin, Caroline J. Springer, Richard Marais, Ian Scanlon, Lesley Ogilvie, Frank Friedlos, Lynda K. Hawkins, Douglas Hedley, Silke Schepelmann, Carl M. Hay, Paul L. Hallenbeck
Publikováno v:
Cancer research. 65(12)
Hepatocellular carcinoma is the fifth most common cancer worldwide, and there is no effective therapy for unresectable disease. We have developed a targeted systemic therapy for hepatocellular carcinoma. The gene for a foreign enzyme is selectively e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e34dce90d327385cd2063280814782
https://pubmed.ncbi.nlm.nih.gov/15958540
https://pubmed.ncbi.nlm.nih.gov/15958540
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 7(4)
We have developed a novel therapeutic gene delivery system for oncolytic adenoviruses that takes advantage of the endogenous gene expression machinery (promoters, splicing, polyadenylation signals) of the E3 transcription unit for gene delivery. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4741df13e935dcbb269c69f02e8ca5d9
https://pubmed.ncbi.nlm.nih.gov/12727104
https://pubmed.ncbi.nlm.nih.gov/12727104