Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lynda K. Hawkins"'
Autor:
Pamela S Shirley, Cheng Cheng, Michele Kaloss, David A. Stewart, Paul L. Hallenbeck, Lynda K. Hawkins, Suzanne Forry-Schaudies, Carl M. Hay, P. Seshidhar Reddy, Anthony Marinov, John L. Jakubczak, Ying Huang, Patricia Ryan, Jingping Yang, Yelena Skripchenko, Lori Clarke, Ling Xu, Sandrina Phipps, Shanthi Ganesh
Publikováno v:
Cancer Gene Therapy. 11:555-569
A potentially promising treatment of metastatic cancer is the systemic delivery of oncolytic adenoviruses. This requires engineering viruses which selectively replicate in tumors. We have constructed such an oncolytic adenovirus, OAS403, in which two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ccf2b27147f8d0846314d8ea8c23ab
https://doi.org/10.1038/sj.cgt.7700735
https://doi.org/10.1038/sj.cgt.7700735
Autor:
Terry Hermiston, Lynda K Hawkins
Publikováno v:
Gene Therapy. 8:1132-1141
Genetically modified replication-selective human adenoviruses are currently undergoing testing in the clinical setting as anticancer agents. Coupling the lytic function of these viruses with virus-mediated transgene delivery represents a powerful ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa8ddf4c40154b80128407f8d3ecfbd
https://doi.org/10.1038/sj.gt.3301508
https://doi.org/10.1038/sj.gt.3301508
Publikováno v:
Scopus-Elsevier
There is an open reading frame in the E3 transcription unit of adenovirus type 3 (Ad3) and Ad7 that could encode a protein of 16 kDa (16K protein). Ad3 and Ad7 are members of subgroup B of human adenoviruses. Using a rabbit antipeptide antiserum, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39ca215e86ad1bc4ddf0df4fbfb7dac
https://doi.org/10.1128/jvi.69.7.4292-4298.1995
https://doi.org/10.1128/jvi.69.7.4292-4298.1995
Autor:
William S. M. Wold, Lynda K. Hawkins
Publikováno v:
Virology. 188:486-494
There is an open reading frame between ATG 291 and TGA 612 in the early region E3 transcription unit of adenovirus 2 (Ad2) that could encode a protein of 12,500 MW (12.5K). To address whether this protein is synthesized, we generated an antiserum aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6add1d289849172c8856120e65171356
https://doi.org/10.1016/0042-6822(92)90502-g
https://doi.org/10.1016/0042-6822(92)90502-g
Publikováno v:
Oncogene. 24(52)
Changes initiated at the cellular and systemic levels as a result of viral infection or neoplastic transformation share significant overlap. Therefore, the use of replicating viruses to treat tumors has long been postulated as a promising avenue for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f1f757e3515e6839d4f6aafac52d10
https://pubmed.ncbi.nlm.nih.gov/16299536
https://pubmed.ncbi.nlm.nih.gov/16299536
Autor:
Janet L. Martin, Caroline J. Springer, Richard Marais, Ian Scanlon, Lesley Ogilvie, Frank Friedlos, Lynda K. Hawkins, Douglas Hedley, Silke Schepelmann, Carl M. Hay, Paul L. Hallenbeck
Publikováno v:
Cancer research. 65(12)
Hepatocellular carcinoma is the fifth most common cancer worldwide, and there is no effective therapy for unresectable disease. We have developed a targeted systemic therapy for hepatocellular carcinoma. The gene for a foreign enzyme is selectively e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e34dce90d327385cd2063280814782
https://pubmed.ncbi.nlm.nih.gov/15958540
https://pubmed.ncbi.nlm.nih.gov/15958540
Autor:
John L, Jakubczak, Patricia, Ryan, Mario, Gorziglia, Lori, Clarke, Lynda K, Hawkins, Carl, Hay, Ying, Huang, Michele, Kaloss, Anthony, Marinov, Sandrina, Phipps, Anne, Pinkstaff, Pamela, Shirley, Yelena, Skripchenko, David, Stewart, Suzanne, Forry-Schaudies, Paul L, Hallenbeck
Publikováno v:
Cancer research. 63(7)
The use of oncolytic adenoviruses as a cancer therapeutic is dependent on the lytic properties of the viral life cycle, and the molecular differences between tumor cells and nontumor cells. One strategy for achieving safe and efficacious adenoviral t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c00556e9981ca614f778fbc29cff9e85
https://pubmed.ncbi.nlm.nih.gov/12670895
https://pubmed.ncbi.nlm.nih.gov/12670895
Autor:
Lynda K. Hawkins, David H. Kirn
Publikováno v:
Encyclopedia of Cancer ISBN: 9780122275555
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdf8f931b077ebdbe40ceeaee1a6863b
https://doi.org/10.1016/b0-12-227555-1/00254-9
https://doi.org/10.1016/b0-12-227555-1/00254-9
Autor:
William S. M. Wold, Lynda K. Hawkins
Publikováno v:
Virology. (1):226-233
There is an open reading frame (ORF) between ATG2089 and TGA2856 in the early E3 transcription unit of subgroup B adenovirus 3 (Ad3) that could encode a protein of 20,500 MW (20.5K). This ORF also exists in Ad7, Ad11, and Ad35 (subgroup B). An antipe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72c5af42d33a45f312b779f00ebb484