Zobrazeno 1 - 10
of 331
pro vyhledávání: '"Lynda F Bonewald"'
Autor:
Anika Shimonty, Fabrizio Pin, Matthew Prideaux, Gang Peng, Joshua Huot, Hyeonwoo Kim, Clifford J Rosen, Bruce M Spiegelman, Lynda F Bonewald
Publikováno v:
eLife, Vol 12 (2024)
Irisin, released from exercised muscle, has been shown to have beneficial effects on numerous tissues but its effects on bone are unclear. We found significant sex and genotype differences in bone from wildtype (WT) mice compared to mice lacking Fndc
Externí odkaz:
https://doaj.org/article/8d8cec337c354f358d50ad275d1a6a3e
Autor:
Matt Prideaux, Alberto Smargiassi, Gang Peng, Marco Brotto, Alexander G Robling, Lynda F Bonewald
Publikováno v:
JBMR Plus, Vol 7, Iss 6, Pp n/a-n/a (2023)
ABSTRACT The L‐enantiomer of β‐aminoisobutyric acid (BAIBA) is secreted by contracted muscle in mice, and exercise increases serum levels in humans. In mice, L‐BAIBA reduces bone loss with unloading, but whether it can have a positive effect w
Externí odkaz:
https://doaj.org/article/d0dfca7e0abd44d88acc13980d9fa125
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158381 (2016)
As the β-catenin pathway has been shown to be involved in mechanotransduction, we sought to determine if haploinsufficiency would affect skeletal response to unloading. It has previously been shown that deletion of both alleles of β-catenin in bone
Externí odkaz:
https://doaj.org/article/652763dd9a7e434a9be2297a52e4b7b1
Autor:
Matthew Prideaux, Sarah L Dallas, Ning Zhao, Erica D Johnsrud, Patricia A Veno, Dayong Guo, Yuji Mishina, Stephen E Harris, Lynda F Bonewald
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125731 (2015)
Parathyroid Hormone (PTH) can exert both anabolic and catabolic effects on the skeleton, potentially through expression of the PTH type1 receptor (PTH1R), which is highly expressed in osteocytes. To determine the cellular and molecular mechanisms res
Externí odkaz:
https://doaj.org/article/15c0fa0d8a314063a138ede1478f4633
Autor:
Asiri R Wijenayaka, Masakazu Kogawa, Hui Peng Lim, Lynda F Bonewald, David M Findlay, Gerald J Atkins
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25900 (2011)
Sclerostin is a product of mature osteocytes embedded in mineralised bone and is a negative regulator of bone mass and osteoblast differentiation. While evidence suggests that sclerostin has an anti-anabolic role, the possibility also exists that scl
Externí odkaz:
https://doaj.org/article/3f5c6d5f83b240f389dc651901794d86
Autor:
Tetsuya Yoshimoto, Mizuho Kittaka, Andrew Anh Phuong Doan, Rina Urata, Matthew Prideaux, Roxana E. Rojas, Clifford V. Harding, W. Henry Boom, Lynda F. Bonewald, Edward M. Greenfield, Yasuyoshi Ueki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
MYD88 mediates the signal of bacterial infection. Here, in the context of periodontal infection, the authors show that the MYD88 pathway in osteocytes plays a dominant role in regulating osteolysis.
Externí odkaz:
https://doaj.org/article/e16f005c0ee94c278ec83641515e371c
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-11 (2022)
Abstract In recent years, much progress has been made in understanding the mechanisms of bone growth and development over a lifespan, including the crosstalk between muscle and bone, to achieve optimal structure and function. While there have been si
Externí odkaz:
https://doaj.org/article/c77088b87348426a82c4e37eff233001
Publikováno v:
Current Osteoporosis Reports. 21:303-310
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60f1dbc98394f4a7a532978ba14bfea6
https://doi.org/10.1007/s11914-023-00788-5
https://doi.org/10.1007/s11914-023-00788-5
Autor:
Carolina Medina-Gomez, John P. Kemp, Niki L. Dimou, Eskil Kreiner, Alessandra Chesi, Babette S. Zemel, Klaus Bønnelykke, Cindy G. Boer, Tarunveer S. Ahluwalia, Hans Bisgaard, Evangelos Evangelou, Denise H. M. Heppe, Lynda F. Bonewald, Jeffrey P. Gorski, Mohsen Ghanbari, Serkalem Demissie, Gustavo Duque, Matthew T. Maurano, Douglas P. Kiel, Yi-Hsiang Hsu, Bram C.J. van der Eerden, Cheryl Ackert-Bicknell, Sjur Reppe, Kaare M. Gautvik, Truls Raastad, David Karasik, Jeroen van de Peppel, Vincent W. V. Jaddoe, André G. Uitterlinden, Jonathan H. Tobias, Struan F.A. Grant, Pantelis G. Bagos, David M. Evans, Fernando Rivadeneira
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Author summary Bone mineral density and lean skeletal mass are heritable traits. Here, Medina-Gomez and colleagues perform bivariate GWAS analyses of total body lean mass and bone mass density in children, and show genetic loci with pleiotropic effec
Externí odkaz:
https://doaj.org/article/c29862cdbe2e426d82346b87b13a5d6e
Publikováno v:
Calcified Tissue International.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9839f194f3aa1f6292f00430fa16195
https://doi.org/10.1007/s00223-023-01093-0
https://doi.org/10.1007/s00223-023-01093-0