Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Lynda D. Hester"'
Autor:
George K Todd, Casey A Boosalis, Aaron A Burzycki, Michael Q Steinman, Lynda D Hester, Pete W Shuster, Randen L Patterson
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e58996 (2013)
One of the goals in neuroscience is to obtain tractable laboratory cultures that closely recapitulate in vivo systems while still providing ease of use in the lab. Because neurons can exist in the body over a lifetime, long-term culture systems are n
Externí odkaz:
https://doaj.org/article/916b52d101b544c5a3651e4c466d954c
Autor:
Paul M. Kim, Clayton Hardman, Michael D. Kornberg, Lynda D. Hester, Akira J. Shimizu, Paul A. Wender, Efrat Abramson, Solomon H. Snyder, Soonmyung Hwang
Publikováno v:
Cell Chem Biol
SUMMARYNeuroinflammation characterizes multiple neurologic diseases, including primary inflammatory conditions such as multiple sclerosis (MS) and classical neurodegenerative diseases. Aberrant activation of the innate immune system contributes to di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b666e86524e75b7d7f33020c7bab1ef
https://pubmed.ncbi.nlm.nih.gov/33472023
https://pubmed.ncbi.nlm.nih.gov/33472023
Autor:
Anthony Lin, Adarsha P. Malla, Cristina Ricco, Bindu D. Paul, Risheng Xu, Chirag Vasavda, Harry Saavedra, Lauren K. Albacarys, Ming Ji, Ruchita Kothari, Robert Tokhunts, Lynda D. Hester, Juan I. Sbodio, Solomon H. Snyder, Thomas W. Sedlak, Adele M. Snowman
Publikováno v:
Cell Chemical Biology. 26:1450-1460.e7
Summary Bilirubin is one of the most frequently measured metabolites in medicine, yet its physiologic roles remain unclear. Bilirubin can act as an antioxidant in vitro, but whether its redox activity is physiologically relevant is unclear because ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb2915e9bda924c5eed90ded5347ffb
https://doi.org/10.1016/j.chembiol.2019.07.006
https://doi.org/10.1016/j.chembiol.2019.07.006
Autor:
Joseph A. Gogos, Jun Mukai, Balakrishnan Selvakumar, Lynda D. Hester, Yuxuan Wang, Solomon H. Snyder, Gary P.H. Ho
Publikováno v:
Neuron. 71(1):131-141
SummaryPSD-95, a principal scaffolding component of the postsynaptic density, is targeted to synapses by palmitoylation, where it couples NMDA receptor stimulation to production of nitric oxide (NO) by neuronal nitric oxide synthase (nNOS). Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5ab97edd3b7a0fe73540bf69ad3fba
Autor:
Minori Koga, Akira Sawa, Lynda D. Hester, Anthony V. Serritella, Thomas W. Sedlak, Solomon H. Snyder, Akiko Hayashi-Takagi, Marcus M. Messmer
Publikováno v:
Biochemical and Biophysical Research Communications. 409:596-602
Glutamate, the principal excitatory neurotransmitter of the brain, participates in a multitude of physiologic and pathologic processes, including learning and memory. Glutathione, a tripeptide composed of the amino acids glutamate, cysteine, and glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3085c419edc80b89050ca130e87c4ba8
https://doi.org/10.1016/j.bbrc.2011.04.087
https://doi.org/10.1016/j.bbrc.2011.04.087
Autor:
Lindsey Law, Nilkantha Sen, Lynda D. Hester, Judy V. Nguyen, Makoto R. Hara, Michael D. Kornberg, Krishna R. Juluri, Adele M. Snowman, Solomon H. Snyder
Publikováno v:
Nature cell biology
S-nitrosylation of proteins by nitric oxide is a major mode of signalling in cells. S-nitrosylation can mediate the regulation of a range of proteins, including prominent nuclear proteins, such as HDAC2 (ref. 2) and PARP1 (ref. 3). The high reactivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15269615de2f4b99fcaec4fc2f9a797b
https://doi.org/10.1038/ncb2114
https://doi.org/10.1038/ncb2114
Publikováno v:
Proceedings of the National Academy of Sciences. 105:10537-10540
Glutamate/ N -methyl- d -aspartate (NMDA) receptor-mediated neurotoxicity involves cyclooxygenase (COX)-2. We demonstrate that this neurotoxicity reflects activation of COX-2 by S -nitrosylation after selective binding of neuronal nitric oxide syntha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63123ca40c944638c168b736bdb11fbe
https://doi.org/10.1073/pnas.0804852105
https://doi.org/10.1073/pnas.0804852105
Autor:
Lynda D. Hester, Hongbo R. Luo, Jing Tian, Yunfei Huang, Yi Liu, Solomon H. Snyder, Bingnan N. Kang
Publikováno v:
The Journal of Neuroscience. 27:449-458
Neuronal activity influences protein synthesis and neuronal growth. Availability of nutrients, especially leucine and arginine, regulates the mammalian target of rapamycin (mTOR) pathway that controls cell growth. We show that NMDA receptor activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1dbfb0e214ddf0593dabb6efb675c03
https://doi.org/10.1523/jneurosci.4489-06.2007
https://doi.org/10.1523/jneurosci.4489-06.2007
Autor:
Sangwon F. Kim, Vassilios Papadopoulos, Lynda D. Hester, Solomon H. Snyder, Stanley E. Patterson, Kathleen W. Clancy, Jaime H. Cheah
Publikováno v:
Neuron. 51:431-440
SummaryDexras1 is a 30 kDa G protein in the Ras subfamily whose discovery was based on its pronounced inducibility by the glucocorticoid dexamethasone. It binds to neuronal nitric oxide synthase (nNOS) via the adaptor protein CAPON, eliciting S-nitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40044b74b3ab503a3670a99a249925e
https://doi.org/10.1016/j.neuron.2006.07.011
https://doi.org/10.1016/j.neuron.2006.07.011
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding
Autor:
Nishant Agrawal, Lynda D. Hester, Yuji Ozeki, Sangwon F. Kim, Jaime H. Cheah, Makoto R. Hara, Stephanie Tankou, Akira Sawa, Matthew B. Cascio, Masahiro Fujimuro, Solomon H. Snyder, S. Diane Hayward, Christopher D. Ferris, Masaaki Takahashi
Publikováno v:
Nature Cell Biology. 7:665-674
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) influences cytotoxicity, translocating to the nucleus during apoptosis. Here we report a signalling pathway in which nitric oxide (NO) generation that follows apoptotic stimulation elicits S-nitrosylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cfa181b6fc44ec5be8f430cddf5d923
https://doi.org/10.1038/ncb1268
https://doi.org/10.1038/ncb1268