Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Lynda Coughlan"'
Autor:
Carly M. Bliss, Sarah L. Hulin-Curtis, Marta Williams, Mahulena Marušková, James A. Davies, Evelina Statkute, Alexander T. Baker, Louise Stack, Lucas Kerstetter, Lauren E. Kerr-Jones, Kate F. Milward, Gabrielle Russell, Sarah J. George, Luned M. Badder, Richard J. Stanton, Lynda Coughlan, Ian R. Humphreys, Alan L. Parker
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101308- (2024)
Adenoviruses (Ads) have demonstrated significant success as replication-deficient (RD) viral vectored vaccines, as well as broad potential across gene therapy and cancer therapy. Ad vectors transduce human cells via direct interactions between the vi
Externí odkaz:
https://doaj.org/article/2537722157ec439c93f92451f7495d20
Autor:
Carly M. Bliss, Raffael Nachbagauer, Chiara Mariottini, Frans Cuevas, Jodi Feser, Abdi Naficy, David I. Bernstein, Jeffrey Guptill, Emmanuel B. Walter, Francesco Berlanda-Scorza, Bruce L. Innis, Adolfo García-Sastre, Peter Palese, Florian Krammer, Lynda Coughlan
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105153- (2024)
Summary: Background: The development of a universal influenza virus vaccine, to protect against both seasonal and pandemic influenza A viruses, is a long-standing public health goal. The conserved stalk domain of haemagglutinin (HA) is a promising va
Externí odkaz:
https://doaj.org/article/c9ca6df22ec740d499055ef8fed469f9
Autor:
Robert Haupt, Lauren Baracco, Erin M. Harberts, Madhumathi Loganathan, Lucas J. Kerstetter, Florian Krammer, Lynda Coughlan, Robert K. Ernst, Matthew B. Frieman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Influenza A virus (IAV) is a leading cause of respiratory disease worldwide often resulting in severe morbidity and mortality. We have previously shown that the Bacterial Enzymatic Combinatorial Chemistry (BECC) adjuvants, BECC438 and BECC47
Externí odkaz:
https://doaj.org/article/6cab5b2e67d042f490774188db3c9224
Autor:
Johannes B. Goll, Aarti Jain, Travis L. Jensen, Rafael Assis, Rie Nakajima, Algis Jasinskas, Lynda Coughlan, Sami R. Cherikh, Casey E. Gelber, S. Khan, D. Huw Davies, Philip Meade, Daniel Stadlbauer, Shirin Strohmeier, Florian Krammer, Wilbur H. Chen, Philip L. Felgner
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract Current seasonal and pre-pandemic influenza vaccines induce short-lived predominantly strain-specific and limited heterosubtypic responses. To better understand how vaccine adjuvants AS03 and MF59 may provide improved antibody responses to v
Externí odkaz:
https://doaj.org/article/5613d64cac7c4b24947caa4bc89283fe
Autor:
Sonia Jangra, Gabriel Laghlali, Angela Choi, Raveen Rathnasinghe, Yong Chen, Soner Yildiz, Lynda Coughlan, Adolfo García-Sastre, Bruno G. De Geest, Michael Schotsaert
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Influenza vaccine effectiveness could be improved by combination with an adjuvant with the potential to enhance the host-vaccine response both quantitatively and qualitatively. The goal of this study was to explore a RIG-I agonist (SDI-nanogel) and a
Externí odkaz:
https://doaj.org/article/8948680f21d34497a5a69b874b6560f4
Autor:
Pauline Maisonnasse, Yoann Aldon, Aurélien Marc, Romain Marlin, Nathalie Dereuddre-Bosquet, Natalia A. Kuzmina, Alec W. Freyn, Jonne L. Snitselaar, Antonio Gonçalves, Tom G. Caniels, Judith A. Burger, Meliawati Poniman, Ilja Bontjer, Virginie Chesnais, Ségolène Diry, Anton Iershov, Adam J. Ronk, Sonia Jangra, Raveen Rathnasinghe, Philip J. M. Brouwer, Tom P. L. Bijl, Jelle van Schooten, Mitch Brinkkemper, Hejun Liu, Meng Yuan, Chad E. Mire, Mariëlle J. van Breemen, Vanessa Contreras, Thibaut Naninck, Julien Lemaître, Nidhal Kahlaoui, Francis Relouzat, Catherine Chapon, Raphaël Ho Tsong Fang, Charlene McDanal, Mary Osei-Twum, Natalie St-Amant, Luc Gagnon, David C. Montefiori, Ian A. Wilson, Eric Ginoux, Godelieve J. de Bree, Adolfo García-Sastre, Michael Schotsaert, Lynda Coughlan, Alexander Bukreyev, Sylvie van der Werf, Jérémie Guedj, Rogier W. Sanders, Marit J. van Gils, Roger Le Grand
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Monoclonal antibodies show great promise in treating Covid-19 patients. Here, Maisonnasse, Aldon and colleagues report pre-clinical results for COVA1-18 and demonstrate that it reduces viral infectivity in three animal models with over 95% efficacy i
Externí odkaz:
https://doaj.org/article/cb63fd675fbc4192b0ac21fa54904b08
Autor:
Weina Sun, Yonghong Liu, Fatima Amanat, Irene González-Domínguez, Stephen McCroskery, Stefan Slamanig, Lynda Coughlan, Victoria Rosado, Nicholas Lemus, Sonia Jangra, Raveen Rathnasinghe, Michael Schotsaert, Jose L. Martinez, Kaori Sano, Ignacio Mena, Bruce L. Innis, Ponthip Wirachwong, Duong Huu Thai, Ricardo Das Neves Oliveira, Rami Scharf, Richard Hjorth, Rama Raghunandan, Florian Krammer, Adolfo García-Sastre, Peter Palese
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Here the authors show that a Newcastle disease virus based COVID-19 vaccine expressing a stabilized spike protein induces protective immunity in small animal models and reduces replication of variants of concerns. This vaccine candidate can be produc
Externí odkaz:
https://doaj.org/article/f1e4a5e7803b4a489c63923de224b4aa
Autor:
Irene González-Domínguez, Jose Luis Martínez, Stefan Slamanig, Nicholas Lemus, Yonghong Liu, Tsoi Ying Lai, Juan Manuel Carreño, Gagandeep Singh, Michael Schotsaert, Ignacio Mena, Stephen McCroskery, Lynda Coughlan, Florian Krammer, Adolfo García-Sastre, Peter Palese, Weina Sun
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT Equitable access to vaccines is necessary to limit the global impact of the coronavirus disease 2019 (COVID-19) pandemic and the emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. In previous studies, we
Externí odkaz:
https://doaj.org/article/68d6371506a14ab1b92c04ed3d25e92f
Autor:
Carly M. Bliss, Andrea J. Parsons, Raffael Nachbagauer, Jennifer R. Hamilton, Federica Cappuccini, Marta Ulaszewska, Jason P. Webber, Aled Clayton, Adrian V.S. Hill, Lynda Coughlan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss , Pp 108-125 (2020)
Adenoviral (Ad) vectors represent promising vaccine platforms for infectious disease. To overcome pre-existing immunity to commonly used human adenovirus serotype 5 (Ad5), vectors based on rare species or non-human Ads are being developed. However, t
Externí odkaz:
https://doaj.org/article/cd6a0c58b0e84b3aad7a70894ddac5d1
Autor:
Raveen Rathnasinghe, Shirin Strohmeier, Fatima Amanat, Virginia L. Gillespie, Florian Krammer, Adolfo García-Sastre, Lynda Coughlan, Michael Schotsaert, Melissa B. Uccellini
Publikováno v:
Emerging Microbes and Infections, Vol 9, Iss 1, Pp 2433-2445 (2020)
ABSTRACTSevere acute respiratory syndrome CoV-2 (SARS-CoV-2) is currently causing a worldwide pandemic with high morbidity and mortality. Development of animal models that recapitulate important aspects of coronavirus disease 2019 (COVID-19) is criti
Externí odkaz:
https://doaj.org/article/e21930afdd594ec99a888b4b02517d52